{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:06:02Z","timestamp":1790622362645,"version":"4.1.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>In children having suffered from neonatal arterial ischemic stroke, the relationship between contralesional hand performance and structural changes in brain areas remote from the infarct site was examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>Using voxel-based morphometry, we correlated contralesional gross manual dexterity assessed by the box and block test and whole-brain gray and white-matter volume changes on high-resolution magnetic resonance imaging in 37 7-year-old post\u2013neonatal arterial ischemic stroke children. We also compared the volume of the identified structures with magnetic resonance imaging data of 10 typically developing age-matched children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>Areas showing the highest positive correlation with the box and block test scores were ipsilesional mediodorsal thalamus, contralesional cerebellar lobule VIIa Crus I, and ipsilesional corticospinal tract at the level of superior corona radiata, the posterior limb of the internal capsule, and the cerebral peduncle and the ipsilesional body of corpus callosum. When compared with typically developing age-matched children, post\u2013neonatal arterial ischemic stroke children with severe contralesional hand motor deficit exhibited significant volume reductions in these structures (except the cerebellum), whereas no differences were found with those with good manual dexterity. No negative correlation was found between box and block test scores and brain areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Contralesional hand performance after neonatal arterial ischemic stroke is correlated with atrophy in brain areas directly or functionally connected but anatomically remote from the infarct. Our study suggests a role of the cerebellar lobule VIIa Crus I and mediodorsal thalamus in manual dexterity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n                      . Unique identifier: NCT02511249.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.116.013545","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T01:56:20Z","timestamp":1462931780000},"page":"1647-1650","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Does Contralesional Hand Function After Neonatal Stroke Only Depend on Lesion Characteristics?"],"prefix":"10.1161","volume":"47","author":[{"given":"Mickael","family":"Dinomais","sequence":"first","affiliation":[{"name":"From the Physical and Rehabilitation Medicine Department (M. Dinomais) and Neurosurgery Department (M. Delion), University Hospital Angers, LUNAM-Angers University, Angers, France; UNIACT-Neurospin, CEA-Saclay, InsermU1129 and Paris-Descartes University, Sorbonne Paris-Cit\u00e9, Paris, France (L.H.-P); Department of Child Neurology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany (S.G.); Pediatric Radiology Department, University Hospital Bic\u00eatre (B.H.) and Pediatric Neurology Department, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Hertz-Pannier","sequence":"additional","affiliation":[{"name":"From the Physical and Rehabilitation Medicine Department (M. Dinomais) and Neurosurgery Department (M. Delion), University Hospital Angers, LUNAM-Angers University, Angers, France; UNIACT-Neurospin, CEA-Saclay, InsermU1129 and Paris-Descartes University, Sorbonne Paris-Cit\u00e9, Paris, France (L.H.-P); Department of Child Neurology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany (S.G.); Pediatric Radiology Department, University Hospital Bic\u00eatre (B.H.) and Pediatric Neurology Department, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Groeschel","sequence":"additional","affiliation":[{"name":"From the Physical and Rehabilitation Medicine Department (M. Dinomais) and Neurosurgery Department (M. Delion), University Hospital Angers, LUNAM-Angers University, Angers, France; UNIACT-Neurospin, CEA-Saclay, InsermU1129 and Paris-Descartes University, Sorbonne Paris-Cit\u00e9, Paris, France (L.H.-P); Department of Child Neurology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany (S.G.); Pediatric Radiology Department, University Hospital Bic\u00eatre (B.H.) and Pediatric Neurology Department, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Delion","sequence":"additional","affiliation":[{"name":"From the Physical and Rehabilitation Medicine Department (M. Dinomais) and Neurosurgery Department (M. Delion), University Hospital Angers, LUNAM-Angers University, Angers, France; UNIACT-Neurospin, CEA-Saclay, InsermU1129 and Paris-Descartes University, Sorbonne Paris-Cit\u00e9, Paris, France (L.H.-P); Department of Child Neurology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany (S.G.); Pediatric Radiology Department, University Hospital Bic\u00eatre (B.H.) and Pediatric Neurology Department, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Husson","sequence":"additional","affiliation":[{"name":"From the Physical and Rehabilitation Medicine Department (M. Dinomais) and Neurosurgery Department (M. Delion), University Hospital Angers, LUNAM-Angers University, Angers, France; UNIACT-Neurospin, CEA-Saclay, InsermU1129 and Paris-Descartes University, Sorbonne Paris-Cit\u00e9, Paris, France (L.H.-P); Department of Child Neurology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany (S.G.); Pediatric Radiology Department, University Hospital Bic\u00eatre (B.H.) and Pediatric Neurology Department, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoelle","family":"Kossorotoff","sequence":"additional","affiliation":[{"name":"From the Physical and Rehabilitation Medicine Department (M. Dinomais) and Neurosurgery Department (M. Delion), University Hospital Angers, LUNAM-Angers University, Angers, France; UNIACT-Neurospin, CEA-Saclay, InsermU1129 and Paris-Descartes University, Sorbonne Paris-Cit\u00e9, Paris, France (L.H.-P); Department of Child Neurology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany (S.G.); Pediatric Radiology Department, University Hospital Bic\u00eatre (B.H.) and Pediatric Neurology Department, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Renaud","sequence":"additional","affiliation":[{"name":"From the Physical and Rehabilitation Medicine Department (M. Dinomais) and Neurosurgery Department (M. Delion), University Hospital Angers, LUNAM-Angers University, Angers, France; UNIACT-Neurospin, CEA-Saclay, InsermU1129 and Paris-Descartes University, Sorbonne Paris-Cit\u00e9, Paris, France (L.H.-P); Department of Child Neurology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany (S.G.); Pediatric Radiology Department, University Hospital Bic\u00eatre (B.H.) and Pediatric Neurology Department, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Chabrier","sequence":"additional","affiliation":[{"name":"From the Physical and Rehabilitation Medicine Department (M. Dinomais) and Neurosurgery Department (M. Delion), University Hospital Angers, LUNAM-Angers University, Angers, France; UNIACT-Neurospin, CEA-Saclay, InsermU1129 and Paris-Descartes University, Sorbonne Paris-Cit\u00e9, Paris, France (L.H.-P); Department of Child Neurology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany (S.G.); Pediatric Radiology Department, University Hospital Bic\u00eatre (B.H.) and Pediatric Neurology Department, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie Nguyen","family":"The Tich","sequence":"additional","affiliation":[{"name":"From the Physical and Rehabilitation Medicine Department (M. Dinomais) and Neurosurgery Department (M. Delion), University Hospital Angers, LUNAM-Angers University, Angers, France; UNIACT-Neurospin, CEA-Saclay, InsermU1129 and Paris-Descartes University, Sorbonne Paris-Cit\u00e9, Paris, France (L.H.-P); Department of Child Neurology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany (S.G.); Pediatric Radiology Department, University Hospital Bic\u00eatre (B.H.) and Pediatric Neurology Department, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.000739"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22950"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0427"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2015.01.007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.633255"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/000841748505200505"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg069"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2013.11.001"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2008.09.013"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01117.2009"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-013-0481-z"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2009.21382"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22997"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.116.013545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:37:18Z","timestamp":1715596638000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.116.013545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1161\/STROKEAHA.116.013545"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.116.013545","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"2016-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}