{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T14:42:02Z","timestamp":1779028922159,"version":"3.51.4"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Background and Purpose\u2014<\/jats:title><jats:p>Epidemiological data about stroke are scarce in low- and middle-income Latin-American countries. We investigated annual incidence of first-ever stroke and transient ischemic attack (TIA) and 30-day case-fatality rates in a population-based setting in Tandil, Argentina.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\u2014<\/jats:title><jats:p>We prospectively identified all first-ever stroke and TIA cases from overlapping sources between January 5, 2013, and April 30, 2015, in Tandil, Argentina. We calculated crude and standardized incidence rates. We estimated 30-day case-fatality rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results\u2014<\/jats:title><jats:p>We identified 334 first-ever strokes and 108 TIAs. Age-standardized incidence rate per 100 000 for Segi\u2019s World population was 76.5 (95% confidence interval [CI], 67.8\u201385.9) for first-ever stroke and 25.1 (95% CI, 20.2\u201330.7) for first-ever TIA, 56.1 (95% CI, 48.8\u201364.2) for ischemic stroke, 13.5 (95% CI, 9.9\u201317.9) for intracerebral hemorrhage, and 4.9 (95% CI, 2.7\u20138.1) for subarachnoid hemorrhage. Stroke incidence was slightly higher for men (87.8; 95% CI, 74.6\u2013102.6) than for women (73.2; 95% CI, 61.7\u201386.1) when standardized for the Argentinean population. Thirty-day case-fatality rate was 14.7% (95% CI, 10.8\u201319.5) for ischemic stroke, 24.1% (95% CI, 14.2\u201336.6) for intracerebral hemorrhage, and 1.9% (95% CI, 0.4\u20135.8) for TIA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions\u2014<\/jats:title><jats:p>This study provides the first prospective population-based stroke and TIA incidence and case-fatality estimate in Argentina. First-ever stroke incidence was lower than that reported in previous Latin-American studies, but first-ever TIA incidence was higher. Thirty-day case-fatality rates were similar to those of other population-based Latin-American studies.<\/jats:p><\/jats:sec>","DOI":"10.1161\/strokeaha.116.013637","type":"journal-article","created":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T05:50:47Z","timestamp":1462513847000},"page":"1640-1642","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["First-Ever Stroke and Transient Ischemic Attack Incidence and 30-Day Case-Fatality Rates in a Population-Based Study in Argentina"],"prefix":"10.1161","volume":"47","author":[{"given":"M. Cecilia","family":"Bahit","sequence":"first","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano L.","family":"Coppola","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia M.","family":"Riccio","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren E.","family":"Cipriano","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory A.","family":"Roth","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato D.","family":"Lopes","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valery L.","family":"Feigin","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Borrego Guerrero","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximiliano","family":"De Martino","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Ferrante","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Funaro","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Lavados","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Laura","family":"Lewin","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H.","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Macarrone","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Marciello","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Marino","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Martens","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Odriozola","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro A.","family":"Rabinstein","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Saposnik","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dami\u00e1n","family":"Silva","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n","family":"Suasnabar","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Truelsen","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Araceli","family":"Uzcudun","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Viviani","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano A.","family":"Sposato","sequence":"additional","affiliation":[{"name":"From the INECO Neurociencias Oro\u00f1o, Rosario, Santa Fe, Argentina (M.C.B.); Hospital Santamarina, Tandil, Buenos Aires, Argentina (M.L.C., M.D.M., A.D., M.L.L., R.M., C.M., G.O., D.S., A.U.); Department of Clinical Neurological Sciences, London Health Sciences Centre, and London Heart &amp; Brain Research Program, Western University, London, Ontario (P.M.R., L.A.S.); Ivey Business School, Western University, London, Ontario, Canada (L.E.C.); Institute for Health Metrics and Evaluation, University of..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","volume-title":"General Assembly, United Nations. 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