{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:35:29Z","timestamp":1790699729618,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack. Clinical scores do not predict the whole vascular recurrence risk; therefore, we aimed to find genetic variants associated with recurrence that might improve the clinical predictive models in IS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>We analyzed 256 polymorphisms from 115 candidate genes in 3 patient cohorts comprising 4482 IS or transient ischemic attack patients. The discovery cohort was prospectively recruited and included 1494 patients, 6.2% of them developed a new IS during the first year of follow-up. Replication analysis was performed in 2988 patients using SNPlex or HumanOmni1-Quad technology. We generated a predictive model using Cox regression (GRECOS score [Genotyping Reurrence Risk of Stroke]) and generated risk groups using a classification tree method.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              The analyses revealed that rs1800801 in the\n              <jats:italic>MGP<\/jats:italic>\n              gene (hazard ratio, 1.33;\n              <jats:italic>P<\/jats:italic>\n              =9\u00d710\n              <jats:sup>\u2212<\/jats:sup>\n              <jats:sup>03<\/jats:sup>\n              ), a gene related to artery calcification, was associated with new IS during the first year of follow-up. This polymorphism was replicated in a Spanish cohort (n=1.305); however, it was not significantly associated in a North American cohort (n=1.683). The GRECOS score predicted new IS (\n              <jats:italic>P<\/jats:italic>\n              =3.2\u00d710\n              <jats:sup>\u2212<\/jats:sup>\n              <jats:sup>09<\/jats:sup>\n              ) and could classify patients, from low risk of stroke recurrence (1.9%) to high risk (12.6%). Moreover, the addition of genetic risk factors to the GRECOS score improves the prediction compared with previous Stroke Prognosis Instrument-II score (\n              <jats:italic>P<\/jats:italic>\n              =0.03).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              The use of genetics could be useful to estimate vascular recurrence risk after IS. Genetic variability in the\n              <jats:italic>MGP<\/jats:italic>\n              gene was associated with vascular recurrence in the Spanish population.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.116.014322","type":"journal-article","created":{"date-parts":[[2017,4,15]],"date-time":"2017-04-15T00:35:28Z","timestamp":1492216528000},"page":"1147-1153","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["GRECOS Project (Genotyping Recurrence Risk of Stroke)"],"prefix":"10.1161","volume":"48","author":[{"given":"Israel","family":"Fern\u00e1ndez-Cadenas","sequence":"first","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"Mendi\u00f3roz","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolors","family":"Giralt","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Nafria","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Garcia","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caty","family":"Carrera","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Gallego-Fabrega","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Domingues-Montanari","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Delgado","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Rib\u00f3","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Castellanos","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marimar","family":"Freijo","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Jim\u00e9nez-Conde","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rubiera","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Alvarez-Sab\u00edn","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Molina","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angels","family":"Font","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Grau Olivares","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"Palomeras","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Perez de la Ossa","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"Martinez-Zabaleta","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Masjuan","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Moniche","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Canovas","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Pi\u00f1ana","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Purroy","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Cocho","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inma","family":"Navas","sequence":"additional","affiliation":[{"name":"From the Stroke Pharmacogenomics and Genetics, Fundacio Doc\u00e8ncia i Recerca MutuaTerrassa, Spain (I.F.-C., E.G., C.G.-F., N.C., E.M.); Neurovascular Research Laboratory and Neurovascular Unit, Neurology and Medicine Departments-Universitat Aut\u00f2noma de Barcelona (I.F.-C., M.M., D.G., C.N., C.C., S.D.-M., P.D., J.M.) and Neurology Department (M.Rib\u00f3, M.Rubiera, J.A.-S., C.A.M.), Vall d\u2019Hebron Hospital, Barcelona, Spain; Neuroepigenetics Research Group, Navarrabiomed, Pamplona, Spain (M.M.); 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