{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:10:21Z","timestamp":1779923421690,"version":"3.53.1"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Accurate long-term outcome prognostication in basilar artery occlusion strokes may guide clinical management in the subacute stage. We determine the prognostic value of the follow-up neurological examination using the National Institutes of Health stroke scale (NIHSS) and identify 24- to 48-hour NIHSS risk categories in basilar artery occlusion patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Participants of an observational registry of radiologically confirmed acute basilar artery occlusion (BASICS [Basilar Artery International Cooperation Study]) with prospectively collected 24- to 48-hour NIHSS and 1-month modified Rankin scale scores were included. Uni- and multivariable modeling were performed to identify independent predictors of poor outcome. Predictive powers of baseline and 24- to 48-hour NIHSS for poor outcome (modified Rankin scale, 4\u20136) and 1-month mortality were determined by receiver operating characteristic analyses. Classification and regression tree analysis was performed to identify risk groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Three hundred seventy-six of 619 BASICS participants were included, of whom 65.4% had poor outcome. In multivariable analyses, 24- to 48-hour NIHSS (odds ratio=1.28 [1.21\u20131.35]), history of minor stroke (odds ratio=2.64 [1.04\u20136.74], time to treatment &gt;6 hours (odds ratio=3.07 [1.35\u20136.99]), and age (odds ratio=1.02 [0.99\u20131.04]) were retained in the final model as predictors of poor outcome. Prognostic power of 24- to 48-hour NIHSS was higher than baseline NIHSS for 1-month poor outcome (area under the curve, 0.92 versus 0.75) and mortality (area under the curve, 0.85 versus 0.72). Classification and regression tree analysis identified five 24- to 48-hour NIHSS risk categories with poor outcome rates of 9.4% (NIHSS 0\u20134), 36% (NIHSS 5\u201311), 84.3% (NIHSS 12\u201322), 96.1% (NIHSS 23\u201327), and 100% (NIHSS\u226528).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Twenty-four- to 48-hour NIHSS accurately predicts 1-month poor outcome and mortality and represents a clinically valuable prognostic tool for the care of basilar artery occlusion patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.116.014567","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T03:36:10Z","timestamp":1472787370000},"page":"2534-2540","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Neurologic Examination at 24 to 48 Hours Predicts Functional Outcomes in Basilar Artery Occlusion Stroke"],"prefix":"10.1161","volume":"47","author":[{"given":"Srikant","family":"Rangaraju","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Emory University Hospital (S.R., M.F., R.G.N.) and Grady Memorial Hospital (S.R., M.F., R.G.N.), Atlanta, GA; Department of Neurology, University of Pittsburgh Medical Center, PA (T.G.J.); Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands (W.J.S., A.A., L.J.K.); Department of Neurology, St Antonius Hospital, Nieuwegein, The Netherlands (W.J.S.); and Department of Epidemiology, Julius Center for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tudor G.","family":"Jovin","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Emory University Hospital (S.R., M.F., R.G.N.) and Grady Memorial Hospital (S.R., M.F., R.G.N.), Atlanta, GA; Department of Neurology, University of Pittsburgh Medical Center, PA (T.G.J.); Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands (W.J.S., A.A., L.J.K.); Department of Neurology, St Antonius Hospital, Nieuwegein, The Netherlands (W.J.S.); and Department of Epidemiology, Julius Center for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Frankel","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Emory University Hospital (S.R., M.F., R.G.N.) and Grady Memorial Hospital (S.R., M.F., R.G.N.), Atlanta, GA; Department of Neurology, University of Pittsburgh Medical Center, PA (T.G.J.); Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands (W.J.S., A.A., L.J.K.); Department of Neurology, St Antonius Hospital, Nieuwegein, The Netherlands (W.J.S.); and Department of Epidemiology, Julius Center for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter J.","family":"Schonewille","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Emory University Hospital (S.R., M.F., R.G.N.) and Grady Memorial Hospital (S.R., M.F., R.G.N.), Atlanta, GA; Department of Neurology, University of Pittsburgh Medical Center, PA (T.G.J.); Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands (W.J.S., A.A., L.J.K.); Department of Neurology, St Antonius Hospital, Nieuwegein, The Netherlands (W.J.S.); and Department of Epidemiology, Julius Center for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale","family":"Algra","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Emory University Hospital (S.R., M.F., R.G.N.) and Grady Memorial Hospital (S.R., M.F., R.G.N.), Atlanta, GA; Department of Neurology, University of Pittsburgh Medical Center, PA (T.G.J.); Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands (W.J.S., A.A., L.J.K.); Department of Neurology, St Antonius Hospital, Nieuwegein, The Netherlands (W.J.S.); and Department of Epidemiology, Julius Center for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Jaap","family":"Kappelle","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Emory University Hospital (S.R., M.F., R.G.N.) and Grady Memorial Hospital (S.R., M.F., R.G.N.), Atlanta, GA; Department of Neurology, University of Pittsburgh Medical Center, PA (T.G.J.); Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands (W.J.S., A.A., L.J.K.); Department of Neurology, St Antonius Hospital, Nieuwegein, The Netherlands (W.J.S.); and Department of Epidemiology, Julius Center for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul G.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Emory University Hospital (S.R., M.F., R.G.N.) and Grady Memorial Hospital (S.R., M.F., R.G.N.), Atlanta, GA; Department of Neurology, University of Pittsburgh Medical Center, PA (T.G.J.); Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands (W.J.S., A.A., L.J.K.); Department of Neurology, St Antonius Hospital, Nieuwegein, The Netherlands (W.J.S.); and Department of Epidemiology, Julius Center for..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.05.020"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.049924"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000121641.77121.98"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-14-200"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000202582.29510.6b"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b605"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824e8f40"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.636928"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.7.952"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000443801"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70173-5"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2007.00145.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.143.1.7063747"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1207\/S15324796ABM2603_02"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1278"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318266fc40"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.116.014567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:48:04Z","timestamp":1715611684000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.116.014567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1161\/STROKEAHA.116.014567"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.116.014567","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"2016-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}