{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T10:35:29Z","timestamp":1763116529752},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2017,4]]},"abstract":"\n Background and Purpose\u2014<\/jats:title>\n After carotid endarterectomy (CEA) or carotid artery stenting (CAS) in patients with transient ischemic attack or minor ischemic stroke, recurrent stroke risk falls to a low rate on modern medical treatment.<\/jats:p>\n <\/jats:sec>\n \n Methods\u2014<\/jats:title>\n We used data from 4583 patients with recent transient ischemic attack or minor stroke enrolled in the TIAregistry.org to perform a nested case\u2013control analysis to evaluate pre- and post-CEA\/CAS risk. Cases were defined as patients with a CEA\/CAS during the 1-year follow-up period. For each case, 2 controls with a follow-up time greater than the time from qualifying event to CEA\/CAS were randomly selected, matched by age and sex. Primary outcome was defined as major vascular events (MVE, including stroke, cardiovascular death, and myocardial infarction).<\/jats:p>\n <\/jats:sec>\n \n Results\u2014<\/jats:title>\n \n The median delay from symptom onset of qualifying event to CEA\/CAS was 11 days (interquartile range, 6\u201323). Overall, patients with CEA\/CAS had a higher 1-year risk of MVE than other patients (14.8% versus 5.8%; adjusted hazard ratio, 2.40; 95% confidence interval, 1.61\u20133.60;\n P<\/jats:italic>\n <0.001). During the matched preprocedural period, MVE occurred in 14 (7.5%) cases and in 13 (3.5%) controls, with an adjusted odds ratio =2.46 (95% confidence interval, 1.07\u20135.64;\n P<\/jats:italic>\n =0.03). In the postprocedural period, the risk of MVE was also higher in cases than in controls (adjusted\n P<\/jats:italic>\n <0.03).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions\u2014<\/jats:title>\n Patients with CEA\/CAS had a higher 12-month risk of MVE, as well as during pre- and postprocedural periods. These results suggest that patients in whom CEA\/CAS is anticipated are likely to be an informative population for inclusion in studies testing new antithrombotic strategies started soon after symptom onset.<\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/strokeaha.116.015171","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T01:30:21Z","timestamp":1489455021000},"page":"1005-1010","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Symptomatic Patients Remain at Substantial Risk of Arterial Disease Complications Before and After Endarterectomy or Stenting"],"prefix":"10.1161","volume":"48","author":[{"given":"Cristina","family":"Hobeanu","sequence":"first","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippa C.","family":"Lavall\u00e9e","sequence":"additional","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Rothwell","sequence":"additional","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Sissani","sequence":"additional","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory W.","family":"Albers","sequence":"additional","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natan M.","family":"Bornstein","sequence":"additional","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis R.","family":"Caplan","sequence":"additional","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey A.","family":"Donnan","sequence":"additional","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Ferro","sequence":"additional","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Hennerici","sequence":"additional","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Labreuche","sequence":"additional","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Molina","sequence":"additional","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe Gabriel","family":"Steg","sequence":"additional","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Jean","family":"Touboul","sequence":"additional","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9ric","family":"Vicaut","sequence":"additional","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence K.S.","family":"Wong","sequence":"additional","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Amarenco","sequence":"additional","affiliation":[{"name":"From APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (C.H., P.C.L., L.S., J.L., P.-J.T., P.A.); Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center (G.W.A.); Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel (N.M.B.); Department of Neurosciences (Neurology), Hospital Santa Maria, University of Lisbon,..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/hs1101.098524"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.1.14"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.11.1974"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12228-3"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)09457-3"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16721-4"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805002"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603060"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr211"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31820d8c98"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412981"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000352050"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)09292-1"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15785-1"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000131083"},{"key":"e_1_3_4_18_2","unstructured":"NICE Guideline 68: Stroke and transient ischaemic attack in over 16s: diagnosis and initial management. https:\/\/www.nice.org.uk\/guidance\/cg68. Published July 2008. Accessed February 2 2017."},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.181486"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000170368.82460.b4"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822b00cf"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2012.00790.x"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002354"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215340"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.673129"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.116.015171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:59:24Z","timestamp":1715612364000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.116.015171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1161\/STROKEAHA.116.015171"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.116.015171","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"2016-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}