{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:20Z","timestamp":1787018120853,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>Transient ischemic attack (TIA) epidemiology may have changed in recent years as a consequence of improved identification and treatment of vascular risk factors. Our aim was to provide updated information about TIA epidemiology in Italy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>Cases of first-ever TIA were ascertained from January 1, 2011, until December 31, 2012, in a population-based prospective registry. All residents in the L\u2019Aquila district with an incident TIA were included and followed up to 2 years after the event. Outcome events were recurrent TIA, nonfatal and fatal stroke, nonfatal and fatal myocardial infarction, and all-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>A total of 210 patients with a TIA according to the traditional time-based definition were included (51.4% women); 151 patients (71.9%) with transient symptoms and negative brain neuroimaging were broadly considered as tissue-based TIA, 29 patients (13.8%) had transient symptoms and evidence of a congruous acute ischemic lesion, and 30 patients (14.3%) had an acute neurovascular syndrome. The crude annual incidence rate for traditional time-based TIA was 35.2 per 100 000 (95% confidence interval, 30.6\u201340.3) and 28.6 per 100 000 (95% confidence interval, 24.1\u201333.5) when standardized to the 2011 European population. The incidence peaked in subjects aged \u226585 years, in both sexes. At 2 years, outcome events occurred in 50 patients (23.8%) including 15 patients (7.1%) with nonfatal or fatal strokes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Our population-based study found a low annual TIA incidence rate and a fair TIA prognosis confirming the effectiveness of preventive strategies for cardiovascular diseases. We also proved the nonfitting applicability of the tissue-based definition in our district.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.116.015417","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T21:04:23Z","timestamp":1485896663000},"page":"530-536","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Epidemiology of Transient Ischemic Attacks Using Time- or Tissue-Based Definitions"],"prefix":"10.1161","volume":"48","author":[{"given":"Diana","family":"Degan","sequence":"first","affiliation":[{"name":"From the Institute of Neurology, Department of Applied Clinical Sciences and Biotechnology, University of L\u2019Aquila, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Ornello","sequence":"additional","affiliation":[{"name":"From the Institute of Neurology, Department of Applied Clinical Sciences and Biotechnology, University of L\u2019Aquila, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Tiseo","sequence":"additional","affiliation":[{"name":"From the Institute of Neurology, Department of Applied Clinical Sciences and Biotechnology, University of L\u2019Aquila, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"De Santis","sequence":"additional","affiliation":[{"name":"From the Institute of Neurology, Department of Applied Clinical Sciences and Biotechnology, University of L\u2019Aquila, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pistoia","sequence":"additional","affiliation":[{"name":"From the Institute of Neurology, Department of Applied Clinical Sciences and Biotechnology, University of L\u2019Aquila, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Carolei","sequence":"additional","affiliation":[{"name":"From the Institute of Neurology, Department of Applied Clinical Sciences and Biotechnology, University of L\u2019Aquila, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Sacco","sequence":"additional","affiliation":[{"name":"From the Institute of Neurology, Department of Applied Clinical Sciences and Biotechnology, University of L\u2019Aquila, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.1.9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.10.2109"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60150-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.37991.635266.44"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.22.2901"},{"key":"e_1_3_3_7_2","first-page":"81","volume-title":"In: Cerebral Vascular Disease","author":"Fisher CM","year":"1958","unstructured":"Fisher CM. 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