{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T21:20:51Z","timestamp":1775769651746,"version":"3.50.1"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>\n              Venous oxygen saturation (SO\n              <jats:sub>2<\/jats:sub>\n              ) is measured in medical fields to assess tissue circulation insufficiency. This study aimed to elucidate the use of a cortical venous redness measurement to evaluate hemodynamic changes during revascularization surgery for patients with moyamoya disease.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>\n              In this retrospective case-series analysis, we first quantitatively measured and correlated SO\n              <jats:sub>2<\/jats:sub>\n              and R intensity of 24-bit color digital red\u2013green\u2013blue pictures of blood samples from 3 volunteers. Subsequently, based on intraoperative digital pictures of 29 patients with moyamoya disease, we measured the R intensities of a cortical vein near the anastomosis site before and after anastomosis. Cerebral blood flow (CBF) at the site was measured using a single-photon emission computed tomography before and 1 to 3 days after surgery. Venous R intensity and CBF were measured twice by 4 raters, and their correlations were examined using generalized linear mixed effect model and linear regression analysis.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              A strong linear correlation was found between blood R intensity and its SO\n              <jats:sub>2<\/jats:sub>\n              (coefficients, 0.522; 95% confidence interval, 0.364\u20130.680, using generalized linear mixed effect model). Venous R intensity before the anastomosis was not correlated with preoperative CBF (coefficients, 0.000352; 95% confidence interval, \u22120.000369 to 0.00107, by generalized linear mixed effect); however, the increases in venous R intensity after anastomosis were correlated with postoperative increases in CBF (\n              <jats:italic>R<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              , 0.367; 95% confidence interval, 0.116\u20130.618 to 0.548; 95% confidence interval, 0.331\u20130.764, by linear regression analysis).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Cortical venous redness represented impaired CBF and could be a useful parameter for assessing hemodynamic changes during revascularization surgery.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.116.015991","type":"journal-article","created":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T01:00:34Z","timestamp":1493254834000},"page":"1665-1667","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Cortical Venous Redness Represents Tissue Circulation Status in Patients With Moyamoya Disease"],"prefix":"10.1161","volume":"48","author":[{"given":"Toshio","family":"Machida","sequence":"first","affiliation":[{"name":"From the Department of Neurosurgery (T.M., S.N., S.I., J.O.), Department of Neurology (Y.A., J.S.), and Department of Radiology (S.M.), Chiba Cerebral and Cardiovascular Center, Japan; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Japan (Y.H., Y.Y.); and Department of Neurosurgery, Chibaken Saiseikai Narashino Hospital, Chiba, Japan (A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Higuchi","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (T.M., S.N., S.I., J.O.), Department of Neurology (Y.A., J.S.), and Department of Radiology (S.M.), Chiba Cerebral and Cardiovascular Center, Japan; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Japan (Y.H., Y.Y.); and Department of Neurosurgery, Chibaken Saiseikai Narashino Hospital, Chiba, Japan (A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Nakano","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (T.M., S.N., S.I., J.O.), Department of Neurology (Y.A., J.S.), and Department of Radiology (S.M.), Chiba Cerebral and Cardiovascular Center, Japan; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Japan (Y.H., Y.Y.); and Department of Neurosurgery, Chibaken Saiseikai Narashino Hospital, Chiba, Japan (A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ishige","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (T.M., S.N., S.I., J.O.), Department of Neurology (Y.A., J.S.), and Department of Radiology (S.M.), Chiba Cerebral and Cardiovascular Center, Japan; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Japan (Y.H., Y.Y.); and Department of Neurosurgery, Chibaken Saiseikai Narashino Hospital, Chiba, Japan (A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Fujikawa","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (T.M., S.N., S.I., J.O.), Department of Neurology (Y.A., J.S.), and Department of Radiology (S.M.), Chiba Cerebral and Cardiovascular Center, Japan; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Japan (Y.H., Y.Y.); and Department of Neurosurgery, Chibaken Saiseikai Narashino Hospital, Chiba, Japan (A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Akaogi","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (T.M., S.N., S.I., J.O.), Department of Neurology (Y.A., J.S.), and Department of Radiology (S.M.), Chiba Cerebral and Cardiovascular Center, Japan; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Japan (Y.H., Y.Y.); and Department of Neurosurgery, Chibaken Saiseikai Narashino Hospital, Chiba, Japan (A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichiro","family":"Shimada","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (T.M., S.N., S.I., J.O.), Department of Neurology (Y.A., J.S.), and Department of Radiology (S.M.), Chiba Cerebral and Cardiovascular Center, Japan; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Japan (Y.H., Y.Y.); and Department of Neurosurgery, Chibaken Saiseikai Narashino Hospital, Chiba, Japan (A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (T.M., S.N., S.I., J.O.), Department of Neurology (Y.A., J.S.), and Department of Radiology (S.M.), Chiba Cerebral and Cardiovascular Center, Japan; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Japan (Y.H., Y.Y.); and Department of Neurosurgery, Chibaken Saiseikai Narashino Hospital, Chiba, Japan (A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigenori","family":"Maru","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (T.M., S.N., S.I., J.O.), Department of Neurology (Y.A., J.S.), and Department of Radiology (S.M.), Chiba Cerebral and Cardiovascular Center, Japan; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Japan (Y.H., Y.Y.); and Department of Neurosurgery, Chibaken Saiseikai Narashino Hospital, Chiba, Japan (A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Ono","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (T.M., S.N., S.I., J.O.), Department of Neurology (Y.A., J.S.), and Department of Radiology (S.M.), Chiba Cerebral and Cardiovascular Center, Japan; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Japan (Y.H., Y.Y.); and Department of Neurosurgery, Chibaken Saiseikai Narashino Hospital, Chiba, Japan (A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000050511"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1992.76.2.0212"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3171\/2015.10.JNS151022"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70240-0"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-014-2161-2"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-011-0331-8"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.cr.2013-0261"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.116.015991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:05:50Z","timestamp":1715612750000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.116.015991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1161\/STROKEAHA.116.015991"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.116.015991","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"2016-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}