{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:36:20Z","timestamp":1767170180108,"version":"build-2238731810"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>We aimed to investigate the optimal timing of diffusion-weighted imaging (DWI) in patients with transient ischemic attack (TIA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>Seventy-three consecutive patients with TIA underwent DWI on admission (initial DWI) and at 24 hours after admission (second DWI). Patients were divided into 2 groups based on initial DWI findings in relation to the second examination: false negative (group 1) and other (group 2). The probability of initial false-negative findings was determined for each hour from TIA onset to initial DWI. Multivariate analysis was used to evaluate the independent risk factors associated with false-negative findings on initial DWI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>\n                      Of the 73 patients examined (56 men; mean age, 68 years), 9 (12%) were categorized into group 1. The latency from TIA onset to initial DWI was 1.7\u00b10.6 hours for group 1 (range, 1\u20132.8 hours) and 3.3\u00b12.6 hours for group 2 (range, 35 minutes to 12 hours). The probability of false-negative findings on initial DWI decreased in a time-dependent manner (25%, 21%, and 7% for 1, 2, and 3 hours, respectively), and no false-negative findings were observed on initial DWI performed at &gt;3 hours from symptom onset. Short latency (\u22642 hours) from TIA onset to initial DWI was an independent risk factor related to false-negative findings (odds ratio, 13.11; 95% confidence interval, 1.07\u2013161.38;\n                      <jats:italic>P<\/jats:italic>\n                      =0.045).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>If the duration between TIA symptom onset and initial DWI is &lt;2 hours, a repeat examination should be performed to minimize the risk of false-negative findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.117.014576","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T21:00:27Z","timestamp":1495573227000},"page":"1990-1992","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Optimal Timing of Diffusion-Weighted Imaging to Avoid False-Negative Findings in Patients With Transient Ischemic Attack"],"prefix":"10.1161","volume":"48","author":[{"given":"Kenji","family":"Shono","sequence":"first","affiliation":[{"name":"From the Department of Neurosurgery (K.S., J.S., Y.T., Y.K., S.N.), Clinical Neuroscience (N.Y., Y.I., R.K.), and Radiology (M.H.), Institute of Biomedical Sciences, Tokushima University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichiro","family":"Satomi","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (K.S., J.S., Y.T., Y.K., S.N.), Clinical Neuroscience (N.Y., Y.I., R.K.), and Radiology (M.H.), Institute of Biomedical Sciences, Tokushima University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiteru","family":"Tada","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (K.S., J.S., Y.T., Y.K., S.N.), Clinical Neuroscience (N.Y., Y.I., R.K.), and Radiology (M.H.), Institute of Biomedical Sciences, Tokushima University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Kanematsu","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (K.S., J.S., Y.T., Y.K., S.N.), Clinical Neuroscience (N.Y., Y.I., R.K.), and Radiology (M.H.), Institute of Biomedical Sciences, Tokushima University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (K.S., J.S., Y.T., Y.K., S.N.), Clinical Neuroscience (N.Y., Y.I., R.K.), and Radiology (M.H.), Institute of Biomedical Sciences, Tokushima University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuishin","family":"Izumi","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (K.S., J.S., Y.T., Y.K., S.N.), Clinical Neuroscience (N.Y., Y.I., R.K.), and Radiology (M.H.), Institute of Biomedical Sciences, Tokushima University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuji","family":"Kaji","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (K.S., J.S., Y.T., Y.K., S.N.), Clinical Neuroscience (N.Y., Y.I., R.K.), and Radiology (M.H.), Institute of Biomedical Sciences, Tokushima University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Harada","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (K.S., J.S., Y.T., Y.K., S.N.), Clinical Neuroscience (N.Y., Y.I., R.K.), and Radiology (M.H.), Institute of Biomedical Sciences, Tokushima University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Nagahiro","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (K.S., J.S., Y.T., Y.K., S.N.), Clinical Neuroscience (N.Y., Y.I., R.K.), and Radiology (M.H.), Institute of Biomedical Sciences, Tokushima University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.604280"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000141703.21173.91"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.477380"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20497"},{"key":"e_1_3_2_6_2","first-page":"1434","article-title":"False-negative diffusion-weighted MR findings in acute ischemic stroke.","volume":"21","author":"Oppenheim C","year":"2000","unstructured":"Oppenheim C, Stanescu R, Dormont D, Crozier S, Marro B, Samson Y, et al.. 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