{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:51:12Z","timestamp":1790495472516,"version":"4.1.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>Long-term exposure to ambient air pollution is associated with higher risk of cardiovascular disease and stroke. We hypothesized that long-term exposure to air pollution would be associated with magnetic resonance imaging markers of subclinical cerebrovascular disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>Participants were 1075 stroke-free individuals aged \u226550 years drawn from the magnetic resonance imaging subcohort of the Northern Manhattan Study who had lived at the same residence for at least 2 years before magnetic resonance imaging. Cross-sectional associations between ambient air pollution and subclinical cerebrovascular disease were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>We found an association between distance to roadway, a proxy for residential exposure to traffic pollution, and white matter hyperintensity volume; however, after adjusting for risk factors, this relationship was no longer present. All other associations between pollutant measures and white matter hyperintensity volume were null. There was no clear association between exposure to air pollutants and subclinical brain infarcts or total cerebral brain volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>We found no evidence that long-term exposure to ambient air pollution is independently associated with subclinical cerebrovascular disease in an urban population-based cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.117.016672","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T21:10:31Z","timestamp":1493413831000},"page":"1966-1968","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Long-Term Exposure to Ambient Air Pollution and Subclinical Cerebrovascular Disease in NOMAS (the Northern Manhattan Study)"],"prefix":"10.1161","volume":"48","author":[{"given":"Erin R.","family":"Kulick","sequence":"first","affiliation":[{"name":"From the Department of Epidemiology, Mailman School of Public Health (E.R.K., M.S.E.), Department of Neurology, College of Physicians and Surgeons (E.R.K., J.T.D., M.S.E.), and Department of Biostatistics, Mailman School of Public Health (Y.K.C.), Columbia University, New York, NY; Department of Epidemiology, Brown University School of Public Health, Providence, RI (G.A.W.); Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle (J.D.K..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Wellenius","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, Mailman School of Public Health (E.R.K., M.S.E.), Department of Neurology, College of Physicians and Surgeons (E.R.K., J.T.D., M.S.E.), and Department of Biostatistics, Mailman School of Public Health (Y.K.C.), Columbia University, New York, NY; Department of Epidemiology, Brown University School of Public Health, Providence, RI (G.A.W.); Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle (J.D.K..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, Mailman School of Public Health (E.R.K., M.S.E.), Department of Neurology, College of Physicians and Surgeons (E.R.K., J.T.D., M.S.E.), and Department of Biostatistics, Mailman School of Public Health (Y.K.C.), Columbia University, New York, NY; Department of Epidemiology, Brown University School of Public Health, Providence, RI (G.A.W.); Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle (J.D.K..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet T.","family":"DeRosa","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, Mailman School of Public Health (E.R.K., M.S.E.), Department of Neurology, College of Physicians and Surgeons (E.R.K., J.T.D., M.S.E.), and Department of Biostatistics, Mailman School of Public Health (Y.K.C.), Columbia University, New York, NY; Department of Epidemiology, Brown University School of Public Health, Providence, RI (G.A.W.); Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle (J.D.K..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick L.","family":"Kinney","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, Mailman School of Public Health (E.R.K., M.S.E.), Department of Neurology, College of Physicians and Surgeons (E.R.K., J.T.D., M.S.E.), and Department of Biostatistics, Mailman School of Public Health (Y.K.C.), Columbia University, New York, NY; Department of Epidemiology, Brown University School of Public Health, Providence, RI (G.A.W.); Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle (J.D.K..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying Kuen","family":"Cheung","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, Mailman School of Public Health (E.R.K., M.S.E.), Department of Neurology, College of Physicians and Surgeons (E.R.K., J.T.D., M.S.E.), and Department of Biostatistics, Mailman School of Public Health (Y.K.C.), Columbia University, New York, NY; Department of Epidemiology, Brown University School of Public Health, Providence, RI (G.A.W.); Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle (J.D.K..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinton B.","family":"Wright","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, Mailman School of Public Health (E.R.K., M.S.E.), Department of Neurology, College of Physicians and Surgeons (E.R.K., J.T.D., M.S.E.), and Department of Biostatistics, Mailman School of Public Health (Y.K.C.), Columbia University, New York, NY; Department of Epidemiology, Brown University School of Public Health, Providence, RI (G.A.W.); Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle (J.D.K..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph L.","family":"Sacco","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, Mailman School of Public Health (E.R.K., M.S.E.), Department of Neurology, College of Physicians and Surgeons (E.R.K., J.T.D., M.S.E.), and Department of Biostatistics, Mailman School of Public Health (Y.K.C.), Columbia University, New York, NY; Department of Epidemiology, Brown University School of Public Health, Providence, RI (G.A.W.); Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle (J.D.K..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell S.","family":"Elkind","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology, Mailman School of Public Health (E.R.K., M.S.E.), Department of Neurology, College of Physicians and Surgeons (E.R.K., J.T.D., M.S.E.), and Department of Biostatistics, Mailman School of Public Health (Y.K.C.), Columbia University, New York, NY; Department of Epidemiology, Brown University School of Public Health, Providence, RI (G.A.W.); Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle (J.D.K..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.570044"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70170-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000068408.82115.D2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022066"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30073-4"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312093292401"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws169"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.008348"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24460"},{"key":"e_1_3_3_11_2","unstructured":"Semmens EO. Effects of traffic-related air pollution on cognitive function dementia risk and brain MRI findings in the Cardiovascular Health Study. Research Works Archive. http:\/\/hdl.handle.net\/1773\/21903. Published February 25 2013.Accessed June 3 2015."},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-151143"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/es8030837"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10899"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.117.016672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:05:54Z","timestamp":1715598354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.117.016672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1161\/STROKEAHA.117.016672"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.117.016672","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"2017-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}