{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:27:44Z","timestamp":1783776464508,"version":"3.55.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Diffusion tensor imaging (DTI) parameters are markers of cerebral lesion in some diseases. In patients with acute subarachnoid hemorrhage (SAH), we investigated whether DTI parameters measured at &lt;72 hours might be associated with delayed cerebral ischemia (DCI) and with poor functional outcome at 3 months (modified Rankin Scale score \u22653).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>DTI was performed in a prospective cohort of 60 patients with nontraumatic SAH at &lt;72 hours. Association of fractional anisotropy and apparent diffusion coefficient values at &lt;72 hours with the occurrence of DCI and outcome at 3 months was evaluated with logistic regression models, adjusting for known predictors of prognosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              At &lt;72 hours after SAH, fractional anisotropy values at the cerebellum were associated with DCI occurrence (78% less odds of DCI for each 0.1 increase in fractional anisotropy;\n              <jats:italic>P<\/jats:italic>\n              =0.019). Early apparent diffusion coefficient values were not associated with DCI. After adjusting for confounding variables, an increase of 10 U in apparent diffusion coefficient at the frontal centrum semiovale corresponded to 15% increased odds of poor outcome (\n              <jats:italic>P<\/jats:italic>\n              =0.061).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>DTI parameters at &lt;72 hours post-SAH are independently associated with the occurrence of DCI and functional outcome. These preliminary results suggest the role of DTI parameters as surrogate markers of prognosis in nontraumatic SAH.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.117.016811","type":"journal-article","created":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T01:00:35Z","timestamp":1498870835000},"page":"2091-2097","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Early Prediction of Delayed Ischemia and Functional Outcome in Acute Subarachnoid Hemorrhage"],"prefix":"10.1161","volume":"48","author":[{"given":"Isabel","family":"Fragata","sequence":"first","affiliation":[{"name":"From the Neuroradiology Department, Centro Hospitalar Lisboa Central, Portugal (I.F.); Centro de Investiga\u00e7\u00e3o (M.A., A.L.P.), and Unidade C\u00e9rebro-Vascular (A.P.N., P.F.), Centro Hospitalar Lisboa Central, Portugal; NOVA Medical School\/Faculdade de Ci\u00eancias M\u00e9dicas, Lisbon, Portugal (A.L.P.); Radiology Department, Uppsala Universitet Medicinska Fakulteten, Sweden (N.C.M.); and Neurology Department, Centro Hospitalar Lisboa Norte, Portugal and Universidade de Lisboa, Faculdade de Medicina, Instituto..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Alves","sequence":"additional","affiliation":[{"name":"From the Neuroradiology Department, Centro Hospitalar Lisboa Central, Portugal (I.F.); Centro de Investiga\u00e7\u00e3o (M.A., A.L.P.), and Unidade C\u00e9rebro-Vascular (A.P.N., P.F.), Centro Hospitalar Lisboa Central, Portugal; NOVA Medical School\/Faculdade de Ci\u00eancias M\u00e9dicas, Lisbon, Portugal (A.L.P.); Radiology Department, Uppsala Universitet Medicinska Fakulteten, Sweden (N.C.M.); and Neurology Department, Centro Hospitalar Lisboa Norte, Portugal and Universidade de Lisboa, Faculdade de Medicina, Instituto..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Lu\u00edsa","family":"Papoila","sequence":"additional","affiliation":[{"name":"From the Neuroradiology Department, Centro Hospitalar Lisboa Central, Portugal (I.F.); Centro de Investiga\u00e7\u00e3o (M.A., A.L.P.), and Unidade C\u00e9rebro-Vascular (A.P.N., P.F.), Centro Hospitalar Lisboa Central, Portugal; NOVA Medical School\/Faculdade de Ci\u00eancias M\u00e9dicas, Lisbon, Portugal (A.L.P.); Radiology Department, Uppsala Universitet Medicinska Fakulteten, Sweden (N.C.M.); and Neurology Department, Centro Hospitalar Lisboa Norte, Portugal and Universidade de Lisboa, Faculdade de Medicina, Instituto..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paiva","family":"Nunes","sequence":"additional","affiliation":[{"name":"From the Neuroradiology Department, Centro Hospitalar Lisboa Central, Portugal (I.F.); Centro de Investiga\u00e7\u00e3o (M.A., A.L.P.), and Unidade C\u00e9rebro-Vascular (A.P.N., P.F.), Centro Hospitalar Lisboa Central, Portugal; NOVA Medical School\/Faculdade de Ci\u00eancias M\u00e9dicas, Lisbon, Portugal (A.L.P.); Radiology Department, Uppsala Universitet Medicinska Fakulteten, Sweden (N.C.M.); and Neurology Department, Centro Hospitalar Lisboa Norte, Portugal and Universidade de Lisboa, Faculdade de Medicina, Instituto..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Ferreira","sequence":"additional","affiliation":[{"name":"From the Neuroradiology Department, Centro Hospitalar Lisboa Central, Portugal (I.F.); Centro de Investiga\u00e7\u00e3o (M.A., A.L.P.), and Unidade C\u00e9rebro-Vascular (A.P.N., P.F.), Centro Hospitalar Lisboa Central, Portugal; NOVA Medical School\/Faculdade de Ci\u00eancias M\u00e9dicas, Lisbon, Portugal (A.L.P.); Radiology Department, Uppsala Universitet Medicinska Fakulteten, Sweden (N.C.M.); and Neurology Department, Centro Hospitalar Lisboa Norte, Portugal and Universidade de Lisboa, Faculdade de Medicina, Instituto..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Canto-Moreira","sequence":"additional","affiliation":[{"name":"From the Neuroradiology Department, Centro Hospitalar Lisboa Central, Portugal (I.F.); Centro de Investiga\u00e7\u00e3o (M.A., A.L.P.), and Unidade C\u00e9rebro-Vascular (A.P.N., P.F.), Centro Hospitalar Lisboa Central, Portugal; NOVA Medical School\/Faculdade de Ci\u00eancias M\u00e9dicas, Lisbon, Portugal (A.L.P.); Radiology Department, Uppsala Universitet Medicinska Fakulteten, Sweden (N.C.M.); and Neurology Department, Centro Hospitalar Lisboa Norte, Portugal and Universidade de Lisboa, Faculdade de Medicina, Instituto..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Canh\u00e3o","sequence":"additional","affiliation":[{"name":"From the Neuroradiology Department, Centro Hospitalar Lisboa Central, Portugal (I.F.); Centro de Investiga\u00e7\u00e3o (M.A., A.L.P.), and Unidade C\u00e9rebro-Vascular (A.P.N., P.F.), Centro Hospitalar Lisboa Central, Portugal; NOVA Medical School\/Faculdade de Ci\u00eancias M\u00e9dicas, Lisbon, Portugal (A.L.P.); Radiology Department, Uppsala Universitet Medicinska Fakulteten, Sweden (N.C.M.); and Neurology Department, Centro Hospitalar Lisboa Norte, Portugal and Universidade de Lisboa, Faculdade de Medicina, Instituto..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.3.660"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-302804"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.5.658"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70017-5"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/2014.10.JNS14290"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.484360"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1179\/174313209X393564"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.226"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.5137\/1019-5149.JTN.5731-12.1"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.8.1818"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-016-1774-y"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-014-0008-6"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2422051698"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4203"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-005613"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.661116"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.63.3.0355"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000218821.34014.1B"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.8.1156"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841851.2010.495351"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.544700"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.589275"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1159\/000262309"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00341-9"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198001000-00001"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.4.424"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-010-8155-z"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.3171"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.507475"},{"key":"e_1_3_3_31_2","first-page":"356","article-title":"Diffusion tensor imaging of cerebral white matter: a pictorial review of physics, fiber tract anatomy, and tumor imaging patterns.","volume":"25","author":"Jellison BJ","year":"2004","unstructured":"Jellison BJ, Field AS, Medow J, Lazar M, Salamat MS, Alexander AL. 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