{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:23:50Z","timestamp":1770906230940,"version":"3.50.1"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>This study provides the contemporary causes and prognosis of transient ischemic attack (TIA) and minor stroke in Asians and the direct comparisons with non-Asians.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>The TIAregistry.org enrolled 4789 patients (1149 Asians and 3640 non-Asians) with a TIA or minor ischemic stroke within 7 days of onset. Every participating facility had systems dedicated to urgent intervention of TIA\/stroke patients by specialists. The primary outcome was a composite of cardiovascular death, nonfatal stroke, and nonfatal acute coronary syndrome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Approximately 80% of patients were evaluated within 24 hours of symptom onset. At 1 year, there were no differences in the rates of composite cardiovascular events (6.8% versus 6.0%;\n              <jats:italic>P<\/jats:italic>\n              =0.38) and stroke (6.0% versus 4.8%;\n              <jats:italic>P<\/jats:italic>\n              =0.11) between Asians and non-Asians. Asians had a lower risk of cerebrovascular disease (stroke or TIA) than non-Asians (adjusted hazard ratio, 0.79; 95% confidence interval, 0.63\u20130.98;\n              <jats:italic>P<\/jats:italic>\n              =0.03); the difference was primarily driven by a lower rate of TIA in Asians (4.2% versus 8.3%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Moderately severe bleeding was more frequent in Asians (0.8% versus 0.3%;\n              <jats:italic>P<\/jats:italic>\n              =0.02). In multivariable analysis, multiple acute infarcts (\n              <jats:italic>P<\/jats:italic>\n              =0.005) and alcohol consumption (\n              <jats:italic>P<\/jats:italic>\n              =0.02) were independent predictors of stroke recurrence in Asians, whereas intracranial stenosis (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), ABCD\n              <jats:sup>2<\/jats:sup>\n              score (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), atrial fibrillation (\n              <jats:italic>P<\/jats:italic>\n              =0.008), extracranial stenosis (\n              <jats:italic>P<\/jats:italic>\n              =0.03), and previous stroke or TIA (\n              <jats:italic>P<\/jats:italic>\n              =0.03) were independent predictors in non-Asians.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The short-term stroke risk after a TIA or minor stroke was lower than expected when urgent evidence-based care was delivered, irrespective of race\/ethnicity or region. However, the predictors of stroke were different for Asians and non-Asians.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.117.016874","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:50:11Z","timestamp":1496710211000},"page":"1779-1787","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Differences in Characteristics and Outcomes Between Asian and Non-Asian Patients in the TIAregistry.org"],"prefix":"10.1161","volume":"48","author":[{"given":"Takao","family":"Hoshino","sequence":"first","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence K.S.","family":"Wong","sequence":"additional","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Sissani","sequence":"additional","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory W.","family":"Albers","sequence":"additional","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natan M.","family":"Bornstein","sequence":"additional","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis R.","family":"Caplan","sequence":"additional","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey A.","family":"Donnan","sequence":"additional","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Ferro","sequence":"additional","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Hennerici","sequence":"additional","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Labreuche","sequence":"additional","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippa C.","family":"Lavall\u00e9e","sequence":"additional","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Molina","sequence":"additional","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Rothwell","sequence":"additional","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe Gabriel","family":"Steg","sequence":"additional","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Jean","family":"Touboul","sequence":"additional","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9ric","family":"Vicaut","sequence":"additional","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Amarenco","sequence":"additional","affiliation":[{"name":"From the APHP, Department of Neurology and Stroke Center, Bichat Hospital, INSERM LVTS-U1148, DHU FIRE, Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, France (T.H., L.S., P.C.L., P-J.T., P.A.); Clinical Research Center for Medicine, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (S.U.); Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital (L.K.S.W.); Stanford..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.008781"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61953-4"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70248-X"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61448-2"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70019-5"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412981"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000153065.39325.fd"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309023291001"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.12.1494"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000129482.70315.2F"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000195209.26543.8f"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.22.2417"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000024"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.578971"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70340-0"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.014791"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21921"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.505776"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.3.368"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21194"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2007.01902.x"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agg111"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.117.016874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:05:04Z","timestamp":1715612704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.117.016874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1161\/STROKEAHA.117.016874"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.117.016874","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"2017-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}