{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:41:28Z","timestamp":1780047688077,"version":"3.53.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>There are few studies of spinal microvascular pathologies in older adults. We characterized spinal cord microvascular pathologies and examined their associations with other spinal and brain postmortem indices and parkinsonism in older adults.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>We documented 3 features of microvascular pathologies in spinal cord and brain specimens from 165 deceased older participants. We also measured spinal white matter pallor. Parkinsonian signs were assessed with a modified version of the motor section of the Unified Parkinson\u2019s Disease Rating Scale. We examined the associations of spinal arteriolosclerosis with other spinal and brain postmortem indices and parkinsonism proximate to death using regression models which controlled for age and sex.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Microinfarcts and cerebral amyloid angiopathy were not observed within the spinal cord parenchyma. Spinal arteriolosclerosis was observed at all spinal levels (C7, T7, L4, S4) examined and was more severe posteriorly than anteriorly (posterior: 4.3, SD=0.72 versus anterior: 3.9, SD=0.74;\n              <jats:italic>t<\/jats:italic>\n              =14.58;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Arteriolosclerosis was more severe in the spinal cord than in the brain (cord: 4.10, SD=0.70; brain: 3.5, SD=0.98;\n              <jats:italic>t<\/jats:italic>\n              =10.39;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The severity of spinal arteriolosclerosis was associated with spinal white matter pallor (\n              <jats:italic>r<\/jats:italic>\n              =0.47;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Spinal arteriolosclerosis accounted for \u22483% of the variation in parkinsonism in models controlling for age, sex, brain arteriolosclerosis, and cerebrovascular disease pathologies. Further models showed that the association of spinal arteriolosclerosis and parkinsonism was not mediated via spinal white matter pallor.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Although the regional distribution of microvascular pathologies varies within the central nervous system, spinal arteriolosclerosis is common and may contribute to the severity of spinal white matter pallor and parkinsonism in older adults.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.117.017643","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:50:15Z","timestamp":1505955015000},"page":"2792-2798","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Spinal Arteriolosclerosis Is Common in Older Adults and Associated With Parkinsonism"],"prefix":"10.1161","volume":"48","author":[{"given":"Aron S.","family":"Buchman","sequence":"first","affiliation":[{"name":"From the Rush Alzheimer\u2019s Disease Center (A.S.B., S.E.L., S.N., A.K., J.A.S., D.A.B.), Department of Neurological Sciences (A.S.B., S.E.L., J.A.S., D.A.B.), and Department of Pathology (Neuropathology) (S.N., J.A.S.), Rush University Medical Center, Chicago, IL; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (V.G.J.M.V.); and Harvard Medical School, Boston, MA (V.G.J.M.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue E.","family":"Leurgans","sequence":"additional","affiliation":[{"name":"From the Rush Alzheimer\u2019s Disease Center (A.S.B., S.E.L., S.N., A.K., J.A.S., D.A.B.), Department of Neurological Sciences (A.S.B., S.E.L., J.A.S., D.A.B.), and Department of Pathology (Neuropathology) (S.N., J.A.S.), Rush University Medical Center, Chicago, IL; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (V.G.J.M.V.); and Harvard Medical School, Boston, MA (V.G.J.M.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukriti","family":"Nag","sequence":"additional","affiliation":[{"name":"From the Rush Alzheimer\u2019s Disease Center (A.S.B., S.E.L., S.N., A.K., J.A.S., D.A.B.), Department of Neurological Sciences (A.S.B., S.E.L., J.A.S., D.A.B.), and Department of Pathology (Neuropathology) (S.N., J.A.S.), Rush University Medical Center, Chicago, IL; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (V.G.J.M.V.); and Harvard Medical School, Boston, MA (V.G.J.M.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique G.J.M.","family":"VanderHorst","sequence":"additional","affiliation":[{"name":"From the Rush Alzheimer\u2019s Disease Center (A.S.B., S.E.L., S.N., A.K., J.A.S., D.A.B.), Department of Neurological Sciences (A.S.B., S.E.L., J.A.S., D.A.B.), and Department of Pathology (Neuropathology) (S.N., J.A.S.), Rush University Medical Center, Chicago, IL; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (V.G.J.M.V.); and Harvard Medical School, Boston, MA (V.G.J.M.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alifiya","family":"Kapasi","sequence":"additional","affiliation":[{"name":"From the Rush Alzheimer\u2019s Disease Center (A.S.B., S.E.L., S.N., A.K., J.A.S., D.A.B.), Department of Neurological Sciences (A.S.B., S.E.L., J.A.S., D.A.B.), and Department of Pathology (Neuropathology) (S.N., J.A.S.), Rush University Medical Center, Chicago, IL; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (V.G.J.M.V.); and Harvard Medical School, Boston, MA (V.G.J.M.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Schneider","sequence":"additional","affiliation":[{"name":"From the Rush Alzheimer\u2019s Disease Center (A.S.B., S.E.L., S.N., A.K., J.A.S., D.A.B.), Department of Neurological Sciences (A.S.B., S.E.L., J.A.S., D.A.B.), and Department of Pathology (Neuropathology) (S.N., J.A.S.), Rush University Medical Center, Chicago, IL; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (V.G.J.M.V.); and Harvard Medical School, Boston, MA (V.G.J.M.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[{"name":"From the Rush Alzheimer\u2019s Disease Center (A.S.B., S.E.L., S.N., A.K., J.A.S., D.A.B.), Department of Neurological Sciences (A.S.B., S.E.L., J.A.S., D.A.B.), and Department of Pathology (Neuropathology) (S.N., J.A.S.), Rush University Medical Center, Chicago, IL; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (V.G.J.M.V.); and Harvard Medical School, Boston, MA (V.G.J.M.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182299496"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp068043"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.30.3.195"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt089"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/156720512801322663"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv153"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22588"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2012.07.002"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2011.12.053"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.623462"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002175"},{"key":"e_1_3_4_13_2","volume-title":"SAS Institute Inc. 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