{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:28:54Z","timestamp":1783542534449,"version":"3.55.0"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Tandem steno-occlusive lesions were poorly represented in randomized trials and represent a major challenge for endovascular thrombectomy in acute anterior circulation strokes. The impact of the cervical carotid lesion cause (ie, atherosclerotic versus dissection) on outcome of tandem patients endovascularly treated remains to be assessed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>We retrospectively analyzed individual data of prospectively collected consecutive tandem patients treated with endovascular thrombectomy. The primary outcome was favorable outcome at 90 days (modified Rankin Scale score of 0\u20132). Secondary efficacy outcomes included successful reperfusion (modified Thrombolysis in Cerebrovascular Infarction scores of 2b-3), time to reperfusion, and safety outcomes encompassed procedural complications, symptomatic intracerebral hemorrhage, and 90-day mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Among the 295 included patients, 65 had cervical carotid dissection and 230 had cervical carotid atherosclerotic cause. The rate of favorable outcome was 56.3% in the dissection group versus 47.6% in the atherosclerotic arm (center-, age-, and admission National Institutes of Health Stroke Scale\u2013adjusted odds ratio, 1.08; 95% confidence interval, 0.50\u20132.30;\n              <jats:italic>P<\/jats:italic>\n              =0.85). No significant differences were observed in secondary outcomes. The rates of successful reperfusion, symptomatic intracerebral hemorrhage, and 90-day mortality were 78.5% versus 74.5% (\n              <jats:italic>P<\/jats:italic>\n              =0.13), 4.6% versus 5.2% (\n              <jats:italic>P<\/jats:italic>\n              =1.0), and 7.8% versus 15.3% (\n              <jats:italic>P<\/jats:italic>\n              =0.94) in the dissection versus atherosclerotic groups, respectively. The median procedural time was 76 minutes (interquartile range, 52\u201395 minutes) in the dissection group and 67 minutes (interquartile range, 45\u201398 minutes) in the atherosclerotic group (\n              <jats:italic>P<\/jats:italic>\n              =0.24).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>We found no differences in the outcomes of patients with anterior circulation tandem atherosclerotic and dissection lesions treated with endovascular thrombectomy. Further studies are warranted.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.117.018264","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T01:11:48Z","timestamp":1507079508000},"page":"3145-3148","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":79,"title":["Thrombectomy in Acute Stroke With Tandem Occlusions From Dissection Versus Atherosclerotic Cause"],"prefix":"10.1161","volume":"48","author":[{"given":"Benjamin","family":"Gory","sequence":"first","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Piotin","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo C.","family":"Haussen","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Steglich-Arnholm","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Holtmannsp\u00f6tter","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Labreuche","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Taschner","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Eiden","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul G.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Papanagiotou","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Boutchakova","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Lapergue","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Dorn","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Cognard","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Killer-Oberpfalzer","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Mangiafico","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Ribo","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Behme","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro M.","family":"Spiotta","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Mazighi","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Turjman","sequence":"additional","affiliation":[{"name":"From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; University Lille, CHU Lille, EA 2694 - Sant\u00e9 Publique: \u00c9pid\u00e9miologie et Qualit\u00e9 des Soins, France (J.L.); Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T., S.E.); Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the TITAN Investigators*","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08020-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011788"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13287"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4338-y"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000001072"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.117.018264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:46:34Z","timestamp":1715611594000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.117.018264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":6,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1161\/STROKEAHA.117.018264"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.117.018264","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"2017-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}