{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:10:19Z","timestamp":1792098619858,"version":"4.4.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Visit-to-visit and day-to-day blood pressure (BP) variability (BPV) predict an increased risk of cardiovascular events but only reflect 1 form of BPV. Beat-to-beat BPV can be rapidly assessed and might also be predictive.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>In consecutive patients within 6 weeks of transient ischemic attack or nondisabling stroke (Oxford Vascular Study), BPV (coefficient of variation) was measured beat-to-beat for 5 minutes (Finometer), day-to-day for 1 week on home monitoring (3 readings, 3\u00d7 daily), and on awake ambulatory BP monitoring. BPV after 1-month standard treatment was related (Cox proportional hazards) to recurrent stroke and cardiovascular events for 2 to 5 years, adjusted for mean systolic BP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Among 520 patients, 26 had inadequate beat-to-beat recordings, and 22 patients were in atrial fibrillation. Four hundred five patients had all forms of monitoring. Beat-to-beat BPV predicted recurrent stroke and cardiovascular events independently of mean systolic BP (hazard ratio per group SD, stroke: 1.47 [1.12\u20131.91];\n              <jats:italic>P<\/jats:italic>\n              =0.005; cardiovascular events: 1.41 [1.08\u20131.83];\n              <jats:italic>P<\/jats:italic>\n              =0.01), including after adjustment for age and sex (stroke: 1.47 [1.12\u20131.92];\n              <jats:italic>P<\/jats:italic>\n              =0.005) and all risk factors (1.40 [1.00\u20131.94];\n              <jats:italic>P<\/jats:italic>\n              =0.047). Day-to-day BPV was less strongly associated with stroke (adjusted hazard ratio, 1.29 [0.97\u20131.71];\n              <jats:italic>P<\/jats:italic>\n              =0.08) but similarly with cardiovascular events (1.41 [1.09\u20131.83];\n              <jats:italic>P<\/jats:italic>\n              =0.009). BPV on awake ambulatory BP monitoring was nonpredictive (stroke: 0.89 [0.59\u20131.35];\n              <jats:italic>P<\/jats:italic>\n              =0.59; cardiovascular events: 1.08 [0.77\u20131.52];\n              <jats:italic>P<\/jats:italic>\n              =0.65). Despite a weak correlation (\n              <jats:italic>r<\/jats:italic>\n              =0.119;\n              <jats:italic>P<\/jats:italic>\n              =0.02), beat-to-beat BPV was associated with risk of recurrent stroke independently of day-to-day BPV (1.41 [1.05\u20131.90];\n              <jats:italic>P<\/jats:italic>\n              =0.02).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Beat-to-beat BPV predicted recurrent stroke and cardiovascular events, independently of mean systolic BP and risk factors but short-term BPV on ambulatory BP monitoring did not. Beat-to-beat BPV may be a useful additional marker of cardiovascular risk.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.117.019107","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T10:05:25Z","timestamp":1512986725000},"page":"62-67","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":107,"title":["Prognostic Significance of Blood Pressure Variability on Beat-to-Beat Monitoring After Transient Ischemic Attack and Stroke"],"prefix":"10.1161","volume":"49","author":[{"given":"Alastair J.S.","family":"Webb","sequence":"first","affiliation":[{"name":"From the Department of Clinical Neurosciences, Centre for Prevention of Stroke and Dementia, University of Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mazzucco","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Neurosciences, Centre for Prevention of Stroke and Dementia, University of Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxin","family":"Li","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Neurosciences, Centre for Prevention of Stroke and Dementia, University of Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Rothwell","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Neurosciences, Centre for Prevention of Stroke and Dementia, University of Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60309-1"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60308-X"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70066-1"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60235-8"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.104620"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.178657"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003321"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.2.463"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000058493.94875.9F"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16405-2"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/08037051.2013.817814"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-198810000-00006"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/204748739900600508"},{"key":"e_1_3_4_15_2","first-page":"12","article-title":"Prognostic significance of blood pressure variability (BPV) in acute stroke: a systematic review of the literature.","volume":"9","author":"Manning L","year":"2014","unstructured":"Manning L, Thilakawardhana R, Robinson T. 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