{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:38:49Z","timestamp":1790361529361,"version":"4.1.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Although there is no overall association between statin use and intracerebral hemorrhage (ICH), whether there is an increased risk among those with a history of ischemic stroke (IS) or transient ischemic attack (TIA) remains controversial. We evaluated the relationship of preadmission statin use with the risk of ICH in patients with a history of IS or TIA in a population-based cohort.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>The Health Improvement Network primary care database in the United Kingdom was used to identify new users of low-dose aspirin and a matched comparison. Both cohorts were followed to identify incident cases of ICH, with validation by manual review of patient records and linkage to hospitalization data. In a nested case\u2013control study, we compared the adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for ICH based on statin use in the subgroup of individuals with history of IS\/TIA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Last statin use within 1 year of ICH (OR, 0.92; 95% CI [confidence interval], 0.60\u20131.4), last use between 8 days and 1 year (OR, 1.81; 95% CI, 0.99\u20133.28), and statin use at the time of ICH (OR, 0.77; 95% CI, 0.49\u20131.21) were not associated with the overall ICH risk among 157 patients with ICH and 884 controls with a history of IS\/TIA. There was also no difference in 30-day rates of fatal (OR, 0.82; 95% CI, 0.41\u20131.64) or nonfatal (OR, 0.90; 95% CI, 0.51\u20131.57) ICH.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Statin use was not associated with an increased risk of ICH among patients with a previous history of IS\/TIA.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.117.019141","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:11:01Z","timestamp":1508976661000},"page":"3245-3251","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Statins and the Risk of Intracerebral Hemorrhage in Patients With Previous Ischemic Stroke or Transient Ischemic Attack"],"prefix":"10.1161","volume":"48","author":[{"given":"David","family":"Gaist","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Odense University Hospital, Denmark (D.G.); Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense (D.G.); Department of Neurology and Kentucky Neuroscience Institute, University of Kentucky, Lexington (L.B.G.); Spanish Centre for Pharmacoepidemiologic Research (CEIFE), Madrid (L.C.S., L.A.G.R.); and Department of Preventive Medicine and Public Health, Faculty of Medicine, Complutense University of Madrid, Spain (L.C.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry B.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Odense University Hospital, Denmark (D.G.); Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense (D.G.); Department of Neurology and Kentucky Neuroscience Institute, University of Kentucky, Lexington (L.B.G.); Spanish Centre for Pharmacoepidemiologic Research (CEIFE), Madrid (L.C.S., L.A.G.R.); and Department of Preventive Medicine and Public Health, Faculty of Medicine, Complutense University of Madrid, Spain (L.C.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Cea Soriano","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Odense University Hospital, Denmark (D.G.); Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense (D.G.); Department of Neurology and Kentucky Neuroscience Institute, University of Kentucky, Lexington (L.B.G.); Spanish Centre for Pharmacoepidemiologic Research (CEIFE), Madrid (L.C.S., L.A.G.R.); and Department of Preventive Medicine and Public Health, Faculty of Medicine, Complutense University of Madrid, Spain (L.C.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Alberto","family":"Garc\u00eda Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Odense University Hospital, Denmark (D.G.); Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense (D.G.); Department of Neurology and Kentucky Neuroscience Institute, University of Kentucky, Lexington (L.B.G.); Spanish Centre for Pharmacoepidemiologic Research (CEIFE), Madrid (L.C.S., L.A.G.R.); and Department of Preventive Medicine and Public Health, Faculty of Medicine, Complutense University of Madrid, Spain (L.C.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70058-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31357-5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061894"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000314696.61422.12"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15690-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000296277.63350.77"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.055269"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.655894"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12539"},{"key":"e_1_3_3_11_2","unstructured":"IMS Health. 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Proc AMIA Annu Fall Symp. 1996;75\u201379.","journal-title":"Proc AMIA Annu Fall Symp"},{"key":"e_1_3_3_15_2","unstructured":"In Practice Systems Ltd. Gemscript \u00c2 The new DM+D drug dictionary for Vision. http:\/\/www.inps4.co.uk\/my-vision\/news\/gemscript-%C3%82%C2%96-new-dmd-drug-dictionary-vision. Accessed June 16 2016."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13686"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004694"},{"key":"e_1_3_3_18_2","first-page":"A12926","article-title":"New use of low-dose aspirin is not associated with a significantly increased risk of intracranial bleeds: results from a population-based nested case-control study in the United Kingdom.","volume":"134","author":"Rodr\u00edguez L","year":"2016","unstructured":"Rodr\u00edguez L, Gaist D, Soriano-Gabarr\u00f3 S, Cea Soriano L. New use of low-dose aspirin is not associated with a significantly increased risk of intracranial bleeds: results from a population-based nested case-control study in the United Kingdom. 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