{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:53:30Z","timestamp":1787756010551,"version":"build-2784847793"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2018,11]]},"abstract":"\n Background and Purpose\u2014<\/jats:title>\n Recent studies indicate a possible beneficial effect on neuroregeneration and vascular protection of selective serotonin reuptake inhibitors after stroke. We conducted a national multicentre study to explore these effects.<\/jats:p>\n <\/jats:sec>\n \n Methods\u2014<\/jats:title>\n The TALOS study (The Efficacy of Citalopram Treatment in Acute Stroke) is a Danish placebo-controlled, randomized, double-blind study of citalopram started within 7 days after symptom onset to detect improvement in functional outcomes and cardiovascular protection in nondepressed, first-ever ischemic stroke. Study medication was given as add-on to standard medical care and treatment duration and follow-up was 6 months. There were 2 coprimary outcomes: changes in functional disability from 1 to 6 months on the modified Rankin Scale, and a composite vascular end point of transient ischemic attack\/stroke, myocardial infarction, or vascular mortality during the first 6 months.<\/jats:p>\n <\/jats:sec>\n \n Results\u2014<\/jats:title>\n \n We enrolled 642 patients randomized to either citalopram (n=319) or placebo (n=323). Median National Institutes of Health Stroke Scale was 5.3 (range, 0\u201327) versus 4.8 (range, 0\u201328) at admission. Improvement in functional recovery from 1 to 6 months occurred in 160 (50%) patients on citalopram and 136 (42%) on placebo (odds ratio, 1.27; 95% CI, 0.92\u20131.74;\n P<\/jats:italic>\n =0.057). When dropouts before 31 days were excluded (n=90), the analysis population showed an odds ratio of 1.37 (95% CI, 0.97\u20131.91;\n P<\/jats:italic>\n =0.07). During a median follow-up of 150 days, 23 (7%) patients in the citalopram group and 26 (8%) patients in the placebo group had a primary, vascular end point (hazard ratio, 0.89; 95% CI, 0.50\u20131.60;\n P<\/jats:italic>\n =0.24). A total of 28 patients (4%) died (16 versus 12;\n P<\/jats:italic>\n =0.42) during the study.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions\u2014<\/jats:title>\n Early citalopram treatment did not improve functional recovery in nondepressed ischemic stroke patients within the first 6 months, although a borderline statistical significant effect was observed in the analysis population. The risk of cardiovascular events was similar between treatment groups, and citalopram treatment was well tolerated.<\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration\u2014<\/jats:title>\n \n URL:\n https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n . Unique identifier: NCT01937182. URL:\n https:\/\/www.clinicaltrialsregister.eu\/<\/jats:ext-link>\n . EudraCT number: 2013-002253-30.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/strokeaha.117.020067","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T05:14:56Z","timestamp":1539580496000},"page":"2568-2576","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["Neuroregeneration and Vascular Protection by Citalopram in Acute Ischemic Stroke (TALOS)"],"prefix":"10.1161","volume":"49","author":[{"given":"Kristian Lundsgaard","family":"Kraglund","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Acute Stroke Unit, Aarhus University Hospital, Denmark (K.L.K., J.K.M., A.G.D., G.A.)"},{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Denmark (M.M., S.P.J.)"},{"name":"Department of Cardiology, Aarhus University Hospital, Denmark (E.L.G.)"},{"name":"Department of Neurology, Acute Stroke Unit, Aalborg University Hospital, Denmark (B.M.)"},{"name":"Department of Neurology, Acute Stroke Unit, Rigshospitalet, University of Copenhagen, Denmark (S.A.S., H.K.I.)"},{"name":"Faculty of Health, Institute of Clinical Medicine, Aarhus University, Denmark (E.L.G., S.P.J., G.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne Kaergaard","family":"Mortensen","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Acute Stroke Unit, Aarhus University Hospital, Denmark (K.L.K., J.K.M., A.G.D., G.A.)"},{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Denmark (M.M., S.P.J.)"},{"name":"Department of Cardiology, Aarhus University Hospital, Denmark (E.L.G.)"},{"name":"Department of Neurology, Acute Stroke Unit, Aalborg University Hospital, Denmark (B.M.)"},{"name":"Department of Neurology, Acute Stroke Unit, Rigshospitalet, University of Copenhagen, Denmark (S.A.S., H.K.I.)"},{"name":"Faculty of Health, Institute of Clinical Medicine, Aarhus University, Denmark (E.L.G., S.P.J., G.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas Gammelgaard","family":"Damsbo","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Acute Stroke Unit, Aarhus University Hospital, Denmark (K.L.K., J.K.M., A.G.D., G.A.)"},{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Denmark (M.M., S.P.J.)"},{"name":"Department of Cardiology, Aarhus University Hospital, Denmark (E.L.G.)"},{"name":"Department of Neurology, Acute Stroke Unit, Aalborg University Hospital, Denmark (B.M.)"},{"name":"Department of Neurology, Acute Stroke Unit, Rigshospitalet, University of Copenhagen, Denmark (S.A.S., H.K.I.)"},{"name":"Faculty of Health, Institute of Clinical Medicine, Aarhus University, Denmark (E.L.G., S.P.J., G.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Modrau","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Acute Stroke Unit, Aarhus University Hospital, Denmark (K.L.K., J.K.M., A.G.D., G.A.)"},{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Denmark (M.M., S.P.J.)"},{"name":"Department of Cardiology, Aarhus University Hospital, Denmark (E.L.G.)"},{"name":"Department of Neurology, Acute Stroke Unit, Aalborg University Hospital, Denmark (B.M.)"},{"name":"Department of Neurology, Acute Stroke Unit, Rigshospitalet, University of Copenhagen, Denmark (S.A.S., H.K.I.)"},{"name":"Faculty of Health, Institute of Clinical Medicine, Aarhus University, Denmark (E.L.G., S.P.J., G.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie Amalie","family":"Simonsen","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Acute Stroke Unit, Aarhus University Hospital, Denmark (K.L.K., J.K.M., A.G.D., G.A.)"},{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Denmark (M.M., S.P.J.)"},{"name":"Department of Cardiology, Aarhus University Hospital, Denmark (E.L.G.)"},{"name":"Department of Neurology, Acute Stroke Unit, Aalborg University Hospital, Denmark (B.M.)"},{"name":"Department of Neurology, Acute Stroke Unit, Rigshospitalet, University of Copenhagen, Denmark (S.A.S., H.K.I.)"},{"name":"Faculty of Health, Institute of Clinical Medicine, Aarhus University, Denmark (E.L.G., S.P.J., G.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle Klingenberg","family":"Iversen","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Acute Stroke Unit, Aarhus University Hospital, Denmark (K.L.K., J.K.M., A.G.D., G.A.)"},{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Denmark (M.M., S.P.J.)"},{"name":"Department of Cardiology, Aarhus University Hospital, Denmark (E.L.G.)"},{"name":"Department of Neurology, Acute Stroke Unit, Aalborg University Hospital, Denmark (B.M.)"},{"name":"Department of Neurology, Acute Stroke Unit, Rigshospitalet, University of Copenhagen, Denmark (S.A.S., H.K.I.)"},{"name":"Faculty of Health, Institute of Clinical Medicine, Aarhus University, Denmark (E.L.G., S.P.J., G.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Madsen","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Acute Stroke Unit, Aarhus University Hospital, Denmark (K.L.K., J.K.M., A.G.D., G.A.)"},{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Denmark (M.M., S.P.J.)"},{"name":"Department of Cardiology, Aarhus University Hospital, Denmark (E.L.G.)"},{"name":"Department of Neurology, Acute Stroke Unit, Aalborg University Hospital, Denmark (B.M.)"},{"name":"Department of Neurology, Acute Stroke Unit, Rigshospitalet, University of Copenhagen, Denmark (S.A.S., H.K.I.)"},{"name":"Faculty of Health, Institute of Clinical Medicine, Aarhus University, Denmark (E.L.G., S.P.J., 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