{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T22:11:42Z","timestamp":1775945502045,"version":"3.50.1"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Hematoma volume is an important determinant of clinical outcome in spontaneous intracerebral hemorrhage (ICH). We performed a genome-wide association study (GWAS) of hematoma volume with the aim of identifying novel biological pathways involved in the pathophysiology of primary brain injury in ICH.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>\n              We conducted a 2-stage (discovery and replication) case-only genome-wide association study in patients with ICH of European ancestry. We utilized the admission head computed tomography to calculate hematoma volume via semiautomated computer-assisted technique. After quality control and imputation, 7 million genetic variants were available for association testing with ICH volume, which was performed separately in lobar and nonlobar ICH cases using linear regression. Signals with\n              <jats:italic>P<\/jats:italic>\n              &lt;5\u00d710\n              <jats:sup>\u2212<\/jats:sup>\n              <jats:sup>8<\/jats:sup>\n              were pursued in replication and tested for association with admission Glasgow coma scale and 3-month post-ICH dichotomized (0\u20132 versus 3\u20136) modified Rankin Scale using ordinal and logistic regression, respectively.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              The discovery phase included 394 ICH cases (228 lobar and 166 nonlobar) and identified 2 susceptibility loci: a genomic region on 22q13 encompassing\n              <jats:italic>PARVB<\/jats:italic>\n              (top single-nucleotide polymorphism rs9614326: \u03b2, 1.84; SE, 0.32;\n              <jats:italic>P<\/jats:italic>\n              =4.4\u00d710\n              <jats:sup>\u22128<\/jats:sup>\n              ) for lobar ICH volume and an intergenic region overlying numerous copy number variants on\n              <jats:italic>17p12<\/jats:italic>\n              (top single-nucleotide polymorphism rs11655160: \u03b2, 0.95; SE, 0.17;\n              <jats:italic>P<\/jats:italic>\n              =4.3\u00d710\n              <jats:sup>\u22128<\/jats:sup>\n              ) for nonlobar ICH volume. The replication included 240 ICH cases (71 lobar and 169 nonlobar) and corroborated the association for\n              <jats:italic>17p12<\/jats:italic>\n              (\n              <jats:italic>P<\/jats:italic>\n              =0.04; meta-analysis\n              <jats:italic>P<\/jats:italic>\n              =2.5\u00d710\n              <jats:sup>\u22129<\/jats:sup>\n              ; heterogeneity,\n              <jats:italic>P<\/jats:italic>\n              =0.16) but not for 22q13 (\n              <jats:italic>P<\/jats:italic>\n              =0.49). In multivariable analysis, rs11655160 was also associated with lower admission Glasgow coma scale (odds ratio, 0.17;\n              <jats:italic>P<\/jats:italic>\n              =0.004) and increased risk of poor 3-month modified Rankin Scale (odds ratio, 1.94;\n              <jats:italic>P<\/jats:italic>\n              =0.045).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              We identified\n              <jats:italic>17p12<\/jats:italic>\n              as a novel susceptibility risk locus for hematoma volume, clinical severity, and functional outcome in nonlobar ICH. Replication in other ethnicities and follow-up translational studies are needed to elucidate the mechanism mediating the observed association.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.117.020091","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T09:05:20Z","timestamp":1529312720000},"page":"1618-1625","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["<i>17p12<\/i>\n            Influences Hematoma Volume and Outcome in Spontaneous Intracerebral Hemorrhage"],"prefix":"10.1161","volume":"49","author":[{"given":"Sandro","family":"Marini","sequence":"first","affiliation":[{"name":"From the Center for Genomic Medicine (S.M., W.J.D., F.R., C.E.K., C.D.A., J.R.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Devan","sequence":"additional","affiliation":[{"name":"From the Center for Genomic Medicine (S.M., W.J.D., F.R., C.E.K., C.D.A., J.R.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farid","family":"Radmanesh","sequence":"additional","affiliation":[{"name":"From the Center for Genomic Medicine (S.M., W.J.D., F.R., C.E.K., C.D.A., J.R.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Miyares","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston; Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT (L.M., C.M., K.N.S., G.J.F.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Poterba","sequence":"additional","affiliation":[{"name":"Analytic and Translational Genetics Unit (T.P.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn M.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation, Sk\u00e5ne University Hospital, Lund, Sweden (B.M.H., B.N., A.L.)"},{"name":"Department of Clinical Sciences Lund, Neurology, Lund University, Sweden (B.M.H., B.N., A.L.)"},{"name":"Department of Neurology and Rehabilitation Medicine, Sk\u00e5ne University Hospital, Lund, Sweden (B.M.H., B.N., A.L.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Norrving","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation, Sk\u00e5ne University Hospital, Lund, Sweden (B.M.H., B.N., A.L.)"},{"name":"Department of Clinical Sciences Lund, Neurology, Lund University, Sweden (B.M.H., B.N., A.L.)"},{"name":"Department of Neurology and Rehabilitation Medicine, Sk\u00e5ne University Hospital, Lund, Sweden (B.M.H., B.N., A.L.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Jimenez-Conde","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital del Mar Medical Research Institute (IMIM) (J.J.-C., E.G.-S., R.E., E.C.-G., C.S., J.R.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Giralt-Steinhauer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital del Mar Medical Research Institute (IMIM) (J.J.-C., E.G.-S., R.E., E.C.-G., C.S., J.R.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Elosua","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital del Mar Medical Research Institute (IMIM) (J.J.-C., E.G.-S., R.E., E.C.-G., C.S., J.R.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Cuadrado-Godia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital del Mar Medical Research Institute (IMIM) (J.J.-C., E.G.-S., R.E., E.C.-G., C.S., J.R.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Soriano","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital del Mar Medical Research Institute (IMIM) (J.J.-C., E.G.-S., R.E., E.C.-G., C.S., J.R.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaume","family":"Roquer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital del Mar Medical Research Institute (IMIM) (J.J.-C., E.G.-S., R.E., E.C.-G., C.S., J.R.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina E.","family":"Kourkoulis","sequence":"additional","affiliation":[{"name":"From the Center for Genomic Medicine (S.M., W.J.D., F.R., C.E.K., C.D.A., J.R.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison M.","family":"Ayres","sequence":"additional","affiliation":[{"name":"Universitat Aut\u00f3noma de Barcelona, Spain; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA (A.M.A., K.S., S.M.G.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Schwab","sequence":"additional","affiliation":[{"name":"Universitat Aut\u00f3noma de Barcelona, Spain; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA (A.M.A., K.S., S.M.G.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Tirschwell","sequence":"additional","affiliation":[{"name":"Stroke Center, Harborview Medical Center, University of Washington, Seattle (D.L.T.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdy","family":"Selim","sequence":"additional","affiliation":[{"name":"Stroke Division, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (M.S.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devin L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Stroke Program, Department of Neurology, University of Michigan, Ann Arbor (D.L.B.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott L.","family":"Silliman","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Florida College of Medicine, Jacksonville (S.L.S.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradford B.","family":"Worrall","sequence":"additional","affiliation":[{"name":"Department of Neurology and Public Health Sciences, University of Virginia Health System, Charlottesville (B.B.W.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Meschia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Jacksonville, FL (J.F.M.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsea S.","family":"Kidwell","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Arizona, Tucson (C.S.K.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Montaner","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory and Neurovascular Unit, Institut de Recerca, Hospital Vall d\u2019Hebron (J.M., I.F.-C., P.D.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Israel","family":"Fernandez-Cadenas","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory and Neurovascular Unit, Institut de Recerca, Hospital Vall d\u2019Hebron (J.M., I.F.-C., P.D.)"},{"name":"Stroke Pharmacogenomics and Genetics Sant Pau Institute of Research, Barcelona, Spain (I.F.-C.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Delgado","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory and Neurovascular Unit, Institut de Recerca, Hospital Vall d\u2019Hebron (J.M., I.F.-C., P.D.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Universitat Aut\u00f3noma de Barcelona, Spain; Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA (A.M.A., K.S., S.M.G.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Lindgren","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation, Sk\u00e5ne University Hospital, Lund, Sweden (B.M.H., B.N., A.L.)"},{"name":"Department of Clinical Sciences Lund, Neurology, Lund University, Sweden (B.M.H., B.N., A.L.)"},{"name":"Department of Neurology and Rehabilitation Medicine, Sk\u00e5ne University Hospital, Lund, Sweden (B.M.H., B.N., A.L.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Matouk","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston; Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT (L.M., C.M., K.N.S., G.J.F.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin N.","family":"Sheth","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston; Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT (L.M., C.M., K.N.S., G.J.F.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, OH (D.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher D.","family":"Anderson","sequence":"additional","affiliation":[{"name":"From the Center for Genomic Medicine (S.M., W.J.D., F.R., C.E.K., C.D.A., J.R.)"},{"name":"Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Boston (C.D.A., J.R.)"},{"name":"Program in Medical and Population Genetics, Broad Institute, Boston (C.D.A., J.R)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Rosand","sequence":"additional","affiliation":[{"name":"From the Center for Genomic Medicine (S.M., W.J.D., F.R., C.E.K., C.D.A., J.R.)"},{"name":"Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Boston (C.D.A., J.R.)"},{"name":"Program in Medical and Population Genetics, Broad Institute, Boston (C.D.A., J.R)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido J.","family":"Falcone","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston; Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT (L.M., C.M., K.N.S., G.J.F.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the International Stroke Genetics Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.7.987"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70264-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.98"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10140-012-1020-9"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005276"},{"key":"e_1_3_3_7_2","first-page":"666","article-title":"Radiologic estimation of hematoma volume in intracerebral hemorrhage trial by CT scan.","volume":"27","author":"Zimmerman RD","year":"2006","unstructured":"Zimmerman, RD, Maldjian, JA, Brun, NC, Horvath, B, Skolnick, BE. Radiologic estimation of hematoma volume in intracerebral hemorrhage trial by CT scan. AJNR Am J Neuroradiol. 2006;27:666\u2013670.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.501650"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.226"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1582134"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001309"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.02.012"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001912"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24780"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.675181"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000081"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70148-X"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018922"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02838.x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.01.019"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.491779"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.012170"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91639-0"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.12.1497"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000262309"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.116"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1847"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000529"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09534"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70104-7"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182377e12"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c55ed3"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005760"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002792"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003771"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2653"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08872"},{"key":"e_1_3_3_38_2","first-page":"487","article-title":"A tool for selecting SNPs for association studies based on observed linkage disequilibrium patterns.","author":"De La Vega FM","year":"2006","unstructured":"De La Vega, FM, Isaac, HI, Scafe, CR. A tool for selecting SNPs for association studies based on observed linkage disequilibrium patterns. Pac Symp Biocomput. 2006;487\u2013498.","journal-title":"Pac Symp Biocomput"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11232"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.137323.112"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6861907"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000014774.88027.22"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-015-0410-1"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002263"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.114.000858"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004461"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5355-1"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493016641962"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.117.020091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:45:22Z","timestamp":1715611522000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.117.020091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1161\/STROKEAHA.117.020091"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.117.020091","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"2017-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}