{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:45:48Z","timestamp":1790142348676,"version":"4.0.1"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Large artery occlusion (LAO) in ischemic stroke requires recognition and triage to an endovascular stroke treatment center. Noninvasive LAO detection is needed to improve triage.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>\n              Prospective study to test whether noninvasive cerebral oximetry can detect anterior circulation LAO in acute stroke. Interhemispheric \u0394BrSO\n              <jats:sub>2<\/jats:sub>\n              in LAO was compared with controls.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              In LAO stroke, mean interhemispheric \u0394BrSO\n              <jats:sub>2<\/jats:sub>\n              was \u22128.3\u00b15.8% (n=19), compared with 0.4\u00b15.8% in small artery stroke (n=17), 0.4\u00b16.0% in hemorrhagic stroke (n=14), and 0.2\u00b17.5% in subjects without stroke (n=19) (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Endovascular stroke treatment reduced the \u0394BrSO\n              <jats:sub>2<\/jats:sub>\n              in most LAO subjects (16\/19). Discrimination of LAO at a \u22123% \u0394BrSO\n              <jats:sub>2<\/jats:sub>\n              cut had 84% sensitivity and 70% specificity. Addition of the G-FAST clinical score (gaze\u2013face\u2013arm\u2013speech\u2013 time) to the BrSO\n              <jats:sub>2<\/jats:sub>\n              measure had 84% sensitivity and 90% specificity.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Noninvasive cerebral oximetry may help detect LAO in ischemic stroke, particularly when combined with a simple clinical scoring system.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.117.020140","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T10:10:11Z","timestamp":1515579011000},"page":"458-460","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Detection of Anterior Circulation Large Artery Occlusion in Ischemic Stroke Using Noninvasive Cerebral Oximetry"],"prefix":"10.1161","volume":"49","author":[{"given":"Alexander C.","family":"Flint","sequence":"first","affiliation":[{"name":"From the Division of Research, Kaiser Permanente, Oakland, CA (A.C.F.); and Neuroscience Department, Kaiser Permanente, Redwood City, CA (A.C.F., S.G.B., S.P.C., A.V.R., D.P.H., V.A.R., M.P., J.P., N.J.E., S.L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv G.","family":"Bhandari","sequence":"additional","affiliation":[{"name":"From the Division of Research, Kaiser Permanente, Oakland, CA (A.C.F.); and Neuroscience Department, Kaiser Permanente, Redwood City, CA (A.C.F., S.G.B., S.P.C., A.V.R., D.P.H., V.A.R., M.P., J.P., N.J.E., S.L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"Cullen","sequence":"additional","affiliation":[{"name":"From the Division of Research, Kaiser Permanente, Oakland, CA (A.C.F.); and Neuroscience Department, Kaiser Permanente, Redwood City, CA (A.C.F., S.G.B., S.P.C., A.V.R., D.P.H., V.A.R., M.P., J.P., N.J.E., S.L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adhikari V.","family":"Reddy","sequence":"additional","affiliation":[{"name":"From the Division of Research, Kaiser Permanente, Oakland, CA (A.C.F.); and Neuroscience Department, Kaiser Permanente, Redwood City, CA (A.C.F., S.G.B., S.P.C., A.V.R., D.P.H., V.A.R., M.P., J.P., N.J.E., S.L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Hsu","sequence":"additional","affiliation":[{"name":"From the Division of Research, Kaiser Permanente, Oakland, CA (A.C.F.); and Neuroscience Department, Kaiser Permanente, Redwood City, CA (A.C.F., S.G.B., S.P.C., A.V.R., D.P.H., V.A.R., M.P., J.P., N.J.E., S.L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek A.","family":"Rao","sequence":"additional","affiliation":[{"name":"From the Division of Research, Kaiser Permanente, Oakland, CA (A.C.F.); and Neuroscience Department, Kaiser Permanente, Redwood City, CA (A.C.F., S.G.B., S.P.C., A.V.R., D.P.H., V.A.R., M.P., J.P., N.J.E., S.L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minal","family":"Patel","sequence":"additional","affiliation":[{"name":"From the Division of Research, Kaiser Permanente, Oakland, CA (A.C.F.); and Neuroscience Department, Kaiser Permanente, Redwood City, CA (A.C.F., S.G.B., S.P.C., A.V.R., D.P.H., V.A.R., M.P., J.P., N.J.E., S.L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmeen","family":"Pombra","sequence":"additional","affiliation":[{"name":"From the Division of Research, Kaiser Permanente, Oakland, CA (A.C.F.); and Neuroscience Department, Kaiser Permanente, Redwood City, CA (A.C.F., S.G.B., S.P.C., A.V.R., D.P.H., V.A.R., M.P., J.P., N.J.E., S.L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J.","family":"Edwards","sequence":"additional","affiliation":[{"name":"From the Division of Research, Kaiser Permanente, Oakland, CA (A.C.F.); and Neuroscience Department, Kaiser Permanente, Redwood City, CA (A.C.F., S.G.B., S.P.C., A.V.R., D.P.H., V.A.R., M.P., J.P., N.J.E., S.L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila L.","family":"Chan","sequence":"additional","affiliation":[{"name":"From the Division of Research, Kaiser Permanente, Oakland, CA (A.C.F.); and Neuroscience Department, Kaiser Permanente, Redwood City, CA (A.C.F., S.G.B., S.P.C., A.V.R., D.P.H., V.A.R., M.P., J.P., N.J.E., S.L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40809-016-0022-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.13647"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000074"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.115.011426"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.014431"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/108925320400800208"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.016056"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/30\/8\/006"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.117.020140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:51:03Z","timestamp":1715611863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.117.020140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1161\/STROKEAHA.117.020140"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.117.020140","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"2017-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}