{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:21Z","timestamp":1787018121691,"version":"build-2736575974"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2018,4]]},"abstract":"\n Background and Purpose\u2014<\/jats:title>\n The aim of the present study is to investigate the effect of transcranial direct current stimulation on word-finding treatment outcome in subacute poststroke aphasia.<\/jats:p>\n <\/jats:sec>\n \n Methods\u2014<\/jats:title>\n In this multi-center, double-blind, randomized controlled trial with 6-month follow-up, we included 58 patients with subacute aphasia (<3 months poststroke), who were enrolled in a stroke rehabilitation program. Patients participated in 2 separate intervention weeks. Each intervention week included 5 daily sessions of 45-minute word-finding therapy combined with either anodal transcranial direct current stimulation (1 mA, 20 minutes; experimental group) or sham transcranial direct current stimulation (control group) over the left inferior frontal gyrus. The primary outcome measure was the Boston Naming Test. Secondary outcome measures included naming performance for trained\/untrained picture items and verbal communication.<\/jats:p>\n <\/jats:sec>\n \n Results\u2014<\/jats:title>\n Both the experimental (n=26) and the control group (n=32) improved on the Boston Naming Test over the intervention period and 6-month follow-up; however, there were no significant differences between groups. Also for the secondary outcome measures, no significant differences were found.<\/jats:p>\n <\/jats:sec>\n \n Conclusions\u2014<\/jats:title>\n The results of the present study do not support an effect of transcranial direct current stimulation as an adjuvant treatment in subacute poststroke aphasia.<\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration\u2014<\/jats:title>\n \n URL:\n http:\/\/www.trialregister.nl\/trialreg\/admin\/rctview.asp<\/jats:ext-link>\n . Unique identifier: NTR4364.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/strokeaha.117.020197","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T05:05:19Z","timestamp":1520571919000},"page":"1018-1020","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Transcranial Direct Current Stimulation Does Not Improve Language Outcome in Subacute Poststroke Aphasia"],"prefix":"10.1161","volume":"49","author":[{"given":"Kerstin","family":"Spielmann","sequence":"first","affiliation":[{"name":"From Rijndam Rehabilitation, Rotterdam, the Netherlands (K.S., W.M.E.v.d.S.-K., M.H.H.-K., G.M.R.); and Department of Rehabilitation Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands (K.S., W.M.E.v.d.S.-K., G.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Mieke E.","family":"van de Sandt-Koenderman","sequence":"additional","affiliation":[{"name":"From Rijndam Rehabilitation, Rotterdam, the Netherlands (K.S., W.M.E.v.d.S.-K., M.H.H.-K., G.M.R.); and Department of Rehabilitation Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands (K.S., W.M.E.v.d.S.-K., G.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majanka H.","family":"Heijenbrok-Kal","sequence":"additional","affiliation":[{"name":"From Rijndam Rehabilitation, Rotterdam, the Netherlands (K.S., W.M.E.v.d.S.-K., M.H.H.-K., G.M.R.); and Department of Rehabilitation Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands (K.S., W.M.E.v.d.S.-K., G.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard M.","family":"Ribbers","sequence":"additional","affiliation":[{"name":"From Rijndam Rehabilitation, Rotterdam, the Netherlands (K.S., W.M.E.v.d.S.-K., M.H.H.-K., G.M.R.); and Department of Rehabilitation Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands (K.S., W.M.E.v.d.S.-K., G.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-150616"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-1-00633.x"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.03.035"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.11.5.455"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-130333"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.03.029"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-016-1505-z"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2626(03)00119-2"},{"key":"e_1_3_4_10_2","volume-title":"The Boston Naming Test","author":"Kaplan E","year":"1983","unstructured":"Kaplan E, Goodglass H, Weintraub S. The Boston Naming Test. Philadelphia, PA: Lea and Febiger; 1983."},{"key":"e_1_3_4_11_2","volume-title":"The Assessment of Aphasia and Related Disorders","author":"Goodglass H","year":"1972","unstructured":"Goodglass H, Kaplan E. The Assessment of Aphasia and Related Disorders. Philadelphia, PA: Lea and Febiger; 1972."},{"key":"e_1_3_4_12_2","volume-title":"Assessment and Recovery of Verbal Communication in Aphasia [PhD thesis]","author":"Blomert L","year":"1994","unstructured":"Blomert L. Assessment and Recovery of Verbal Communication in Aphasia [PhD thesis]. Nijmegen, the Netherlands: Katholieke Universiteit Nijmegen; 1994."},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_3_4_14_2","first-page":"61","article-title":"Functional evaluation: the Barthel index.","volume":"14","author":"Mahoney FI","year":"1965","unstructured":"Mahoney FI, Barthel DW. Functional evaluation: the Barthel index. Md State Med J. 1965;14:61\u201365.","journal-title":"Md State Med J"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(78)80006-9"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.117.020197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:45:47Z","timestamp":1715597147000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.117.020197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1161\/STROKEAHA.117.020197"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.117.020197","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"2017-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}