{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:54:03Z","timestamp":1790315643088,"version":"4.1.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Proximal artery vasospasm and delayed cerebral ischemia (DCI) after cerebral aneurysm rupture result in reduced cerebral perfusion and microperfusion and significant morbidity and mortality. Intravoxel incoherent motion (IVIM) magnetic resonance imaging extracts microvascular perfusion information from a multi-b value diffusion-weighted sequence. We determined whether decreased IVIM perfusion may identify patients with proximal artery vasospasm and DCI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>We performed a pilot retrospective cohort study of patients with ruptured cerebral aneurysms. Consecutive patients who underwent a brain magnetic resonance imaging with IVIM after ruptured aneurysm treatment were included. Patient demographic, treatment, imaging, and outcome data were determined by electronic medical record review. Primary outcome was DCI development with proximal artery vasospasm that required endovascular treatment. Secondary outcomes included mortality and clinical outcomes at 6 months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Sixteen patients (11 females, 69%;\n              <jats:italic>P<\/jats:italic>\n              =0.9) were included. There were no differences in age, neurological status, or comorbidities between patients who subsequently underwent endovascular treatment of DCI (10 patients; DCI+ group) and those who did not (6 patients; DCI\u2212 group). Compared with DCI\u2212 patients, DCI+ patients had decreased IVIM perfusion fraction\n              <jats:italic>f<\/jats:italic>\n              (0.09\u00b10.03 versus 0.13\u00b10.01;\n              <jats:italic>P<\/jats:italic>\n              =0.03), reduced diffusion coefficient\n              <jats:italic>D<\/jats:italic>\n              (0.82\u00b10.05 versus 0.92\u00b10.07\u00d710\n              <jats:sup>\u22123<\/jats:sup>\n              mm\n              <jats:sup>2<\/jats:sup>\n              \/s;\n              <jats:italic>P<\/jats:italic>\n              =0.003), and reduced blood flow\u2013related parameter\n              <jats:italic>fD<\/jats:italic>\n              * (1.18\u00b10.40 versus 1.83\u00b10.40\u00d710\n              <jats:sup>\u22123<\/jats:sup>\n              mm\n              <jats:sup>2<\/jats:sup>\n              \/s;\n              <jats:italic>P<\/jats:italic>\n              =0.009). IVIM pseudodiffusion coefficient\n              <jats:italic>D<\/jats:italic>\n              * did not differ between DCI\u2212 (0.011\u00b10.002) and DCI+ (0.013\u00b10.005 mm\n              <jats:sup>2<\/jats:sup>\n              \/s;\n              <jats:italic>P<\/jats:italic>\n              =0.4) patients. No differences in mortality or clinical outcome were identified.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              Decreased IVIM perfusion fraction\n              <jats:italic>f<\/jats:italic>\n              and blood flow\u2013related parameter\n              <jats:italic>fD<\/jats:italic>\n              * correlate with DCI and proximal artery vasospasm development after cerebral aneurysm rupture.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.117.020395","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T10:05:13Z","timestamp":1518170713000},"page":"741-745","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Reduced Intravoxel Incoherent Motion Microvascular Perfusion Predicts Delayed Cerebral Ischemia and Vasospasm After Aneurysm Rupture"],"prefix":"10.1161","volume":"49","author":[{"given":"Jeremy J.","family":"Heit","sequence":"first","affiliation":[{"name":"From the Department of Radiology (J.J.H., M.W., B.W.M., G.Z., M.P.M., G.Z., H.M.D.), Department of Neurosurgery (R.L.D., G.K.S.), and Department of Neurology (M.G.L., G.W.A.), Stanford Healthcare, CA; and Department of Radiology, University of Basle, Diagnostic and Interventional Neuroradiology, Petersgraben, Switzerland (C.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Wintermark","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (J.J.H., M.W., B.W.M., G.Z., M.P.M., G.Z., H.M.D.), Department of Neurosurgery (R.L.D., G.K.S.), and Department of Neurology (M.G.L., G.W.A.), Stanford Healthcare, CA; and Department of Radiology, University of Basle, Diagnostic and Interventional Neuroradiology, Petersgraben, Switzerland (C.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake W.","family":"Martin","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (J.J.H., M.W., B.W.M., G.Z., M.P.M., G.Z., H.M.D.), Department of Neurosurgery (R.L.D., G.K.S.), and Department of Neurology (M.G.L., G.W.A.), Stanford Healthcare, CA; and Department of Radiology, University of Basle, Diagnostic and Interventional Neuroradiology, Petersgraben, Switzerland (C.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Zhu","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (J.J.H., M.W., B.W.M., G.Z., M.P.M., G.Z., H.M.D.), Department of Neurosurgery (R.L.D., G.K.S.), and Department of Neurology (M.G.L., G.W.A.), Stanford Healthcare, CA; and Department of Radiology, University of Basle, Diagnostic and Interventional Neuroradiology, Petersgraben, Switzerland (C.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Marks","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (J.J.H., M.W., B.W.M., G.Z., M.P.M., G.Z., H.M.D.), Department of Neurosurgery (R.L.D., G.K.S.), and Department of Neurology (M.G.L., G.W.A.), Stanford Healthcare, CA; and Department of Radiology, University of Basle, Diagnostic and Interventional Neuroradiology, Petersgraben, Switzerland (C.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Zaharchuk","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (J.J.H., M.W., B.W.M., G.Z., M.P.M., G.Z., H.M.D.), Department of Neurosurgery (R.L.D., G.K.S.), and Department of Neurology (M.G.L., G.W.A.), Stanford Healthcare, CA; and Department of Radiology, University of Basle, Diagnostic and Interventional Neuroradiology, Petersgraben, Switzerland (C.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Dodd","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (J.J.H., M.W., B.W.M., G.Z., M.P.M., G.Z., H.M.D.), Department of Neurosurgery (R.L.D., G.K.S.), and Department of Neurology (M.G.L., G.W.A.), Stanford Healthcare, CA; and Department of Radiology, University of Basle, Diagnostic and Interventional Neuroradiology, Petersgraben, Switzerland (C.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy M.","family":"Do","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (J.J.H., M.W., B.W.M., G.Z., M.P.M., G.Z., H.M.D.), Department of Neurosurgery (R.L.D., G.K.S.), and Department of Neurology (M.G.L., G.W.A.), Stanford Healthcare, CA; and Department of Radiology, University of Basle, Diagnostic and Interventional Neuroradiology, Petersgraben, Switzerland (C.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary K.","family":"Steinberg","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (J.J.H., M.W., B.W.M., G.Z., M.P.M., G.Z., H.M.D.), Department of Neurosurgery (R.L.D., G.K.S.), and Department of Neurology (M.G.L., G.W.A.), Stanford Healthcare, CA; and Department of Radiology, University of Basle, Diagnostic and Interventional Neuroradiology, Petersgraben, Switzerland (C.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten G.","family":"Lansberg","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (J.J.H., M.W., B.W.M., G.Z., M.P.M., G.Z., H.M.D.), Department of Neurosurgery (R.L.D., G.K.S.), and Department of Neurology (M.G.L., G.W.A.), Stanford Healthcare, CA; and Department of Radiology, University of Basle, Diagnostic and Interventional Neuroradiology, Petersgraben, Switzerland (C.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W.","family":"Albers","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (J.J.H., M.W., B.W.M., G.Z., M.P.M., G.Z., H.M.D.), Department of Neurosurgery (R.L.D., G.K.S.), and Department of Neurology (M.G.L., G.W.A.), Stanford Healthcare, CA; and Department of Radiology, University of Basle, Diagnostic and Interventional Neuroradiology, Petersgraben, Switzerland (C.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Federau","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (J.J.H., M.W., B.W.M., G.Z., M.P.M., G.Z., H.M.D.), Department of Neurosurgery (R.L.D., G.K.S.), and Department of Neurology (M.G.L., G.W.A.), Stanford Healthcare, CA; and Department of Radiology, University of Basle, Diagnostic and Interventional Neuroradiology, Petersgraben, Switzerland (C.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.191395"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-011-9605-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182587839"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.4.876"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12120584"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24195"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.168.2.3393671"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3780"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-014-1370-y"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072856"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2016.04.019"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.589275"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22338"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000144866.28101.6D"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.117.020395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:57:00Z","timestamp":1715612220000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.117.020395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1161\/STROKEAHA.117.020395"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.117.020395","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"2017-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}