{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:53:34Z","timestamp":1789145614191,"version":"build-2803163510"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>We assessed whether the load of cerebral small vessel disease (cSVD) and its individual markers, including lacunes, white matter hyperintensities, microbleeds, and enlarged perivascular spaces (EPVS), are associated with arterial stiffness.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>We evaluated cSVD markers in a cohort of 782 hypertensive individuals without history of stroke or dementia. The load of the disease was calculated using an ordinal scale ranging from 0 to 4 (1 point was given for each of the 4 markers examined). The arterial stiffness was tested by measuring the carotid\u2013femoral pulse wave velocity with an oscillometric automatic device.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>The mean age of the participants (49.6% women) was 62.7\u00b15.4 years, and the mean systolic\/diastolic blood pressure was 142.9\/77.3 mm\u2009Hg (55.5% of the participants had poor blood pressure control). We found 7.2% cases with lacunes, 6.4% with microbleeds, 6.7% with extensive white matter hyperintensities, 24.5% with extensive basal ganglia EPVS, and 40.1% with extensive EPVS in the centrum semiovale. Regarding the cSVD load, 19.7% of the participants scored 1, 6.5% scored 2, and 1.4% scored \u22653. The median carotid\u2013femoral pulse wave velocity was 10.5 m\/s (interquartile range, 9.2\u201311.9) and was associated with lacunes (odds ratio per carotid\u2013femoral pulse wave velocity SD increase, 1.51; 95% confidence interval, 1.13\u20132.03), extensive basal ganglia EPVS (odds ratio, 1.39; 95% confidence interval, 1.16\u20131.67), and cSVD load (common odds ratio, 1.42; 95% confidence interval, 1.19\u20131.68).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>We found that, in a cohort of hypertensive individuals, the arterial stiffness is associated with the total load of the cSVD, especially with lacunes and basal ganglia EPVS.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.118.020163","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T09:05:39Z","timestamp":1524042339000},"page":"1279-1281","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":95,"title":["Arterial Stiffness Is Associated With Basal Ganglia Enlarged Perivascular Spaces and Cerebral Small Vessel Disease Load"],"prefix":"10.1161","volume":"49","author":[{"given":"Iolanda","family":"Riba-Llena","sequence":"first","affiliation":[{"name":"From the Neurovascular Laboratory, Vall Hebron\u2019s Research Institute, Barcelona, Spain (I.R.-L., J.J.-B., X.C., A.L.-R., J.M., P.D.)"},{"name":"Neurology Service, Vall Hebron\u2019s University Hospital, Barcelona, Spain (I.R.-L., J.\u00c1.-S.)"},{"name":"Universitat Aut\u00f3noma de Barcelona, Bellaterra, Spain (I.R.-L., J.J.-B., X.C., A.L.-R., X.M., J.\u00c1.-S., J.M., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Jim\u00e9nez-Balado","sequence":"additional","affiliation":[{"name":"From the Neurovascular Laboratory, Vall Hebron\u2019s Research Institute, Barcelona, Spain (I.R.-L., J.J.-B., X.C., A.L.-R., J.M., P.D.)"},{"name":"Universitat Aut\u00f3noma de Barcelona, Bellaterra, Spain (I.R.-L., J.J.-B., X.C., A.L.-R., X.M., J.\u00c1.-S., J.M., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Casta\u00f1\u00e9","sequence":"additional","affiliation":[{"name":"From the Neurovascular Laboratory, Vall Hebron\u2019s Research Institute, Barcelona, Spain (I.R.-L., J.J.-B., X.C., A.L.-R., J.M., P.D.)"},{"name":"Universitat Aut\u00f3noma de Barcelona, Bellaterra, Spain (I.R.-L., J.J.-B., X.C., A.L.-R., X.M., J.\u00c1.-S., J.M., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Girona","sequence":"additional","affiliation":[{"name":"Emergency Department, SCIAS-Hospital de Barcelona, Spain (A.G.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"L\u00f3pez-Rueda","sequence":"additional","affiliation":[{"name":"From the Neurovascular Laboratory, Vall Hebron\u2019s Research Institute, Barcelona, Spain (I.R.-L., J.J.-B., X.C., A.L.-R., J.M., P.D.)"},{"name":"Universitat Aut\u00f3noma de Barcelona, Bellaterra, Spain (I.R.-L., J.J.-B., X.C., A.L.-R., X.M., J.\u00c1.-S., J.M., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Mundet","sequence":"additional","affiliation":[{"name":"Barcelona City Research Support Unit, University Research Institute, IDIAP Jordi Gol, Spain (X.M.)"},{"name":"Universitat Aut\u00f3noma de Barcelona, Bellaterra, Spain (I.R.-L., J.J.-B., X.C., A.L.-R., X.M., J.\u00c1.-S., J.M., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen I.","family":"Jarca","sequence":"additional","affiliation":[{"name":"Primary Care Center Granollers, Institut Catal\u00e0 de la Salut, Spain (C.I.J.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"\u00c1lvarez-Sabin","sequence":"additional","affiliation":[{"name":"Neurology Service, Vall Hebron\u2019s University Hospital, Barcelona, Spain (I.R.-L., J.\u00c1.-S.)"},{"name":"Universitat Aut\u00f3noma de Barcelona, Bellaterra, Spain (I.R.-L., J.J.-B., X.C., A.L.-R., X.M., J.\u00c1.-S., J.M., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Montaner","sequence":"additional","affiliation":[{"name":"From the Neurovascular Laboratory, Vall Hebron\u2019s Research Institute, Barcelona, Spain (I.R.-L., J.J.-B., X.C., A.L.-R., J.M., P.D.)"},{"name":"Universitat Aut\u00f3noma de Barcelona, Bellaterra, Spain (I.R.-L., J.J.-B., X.C., A.L.-R., X.M., J.\u00c1.-S., J.M., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Delgado","sequence":"additional","affiliation":[{"name":"From the Neurovascular Laboratory, Vall Hebron\u2019s Research Institute, Barcelona, Spain (I.R.-L., J.J.-B., X.C., A.L.-R., J.M., P.D.)"},{"name":"Universitat Aut\u00f3noma de Barcelona, Bellaterra, Spain (I.R.-L., J.J.-B., X.C., A.L.-R., X.M., J.\u00c1.-S., J.M., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70104-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.03.011"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X07083392"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-13-130"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002545"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.642264"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.48.suppl_1.wp208"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000168052.00426.65"},{"key":"e_1_3_3_11_2","first-page":"345","article-title":"Biomechanics of brain edema and effects on local cerebral blood flow.","volume":"28","author":"Marmarou A","year":"1980","unstructured":"Marmarou A, Takagi H, Shulman K. Biomechanics of brain edema and effects on local cerebral blood flow. Adv Neurol. 1980;28:345\u2013358.","journal-title":"Adv Neurol"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.118.020163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:18:13Z","timestamp":1715613493000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.118.020163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1161\/STROKEAHA.118.020163"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.118.020163","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"2017-09-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}