{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:16:57Z","timestamp":1790007417646,"version":"4.0.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>Endovascular treatment for acute intracranial atherosclerosis\u2013related large vessel occlusion (ICAS [+]-LVO) is one of the challenging issues in modern mechanical thrombectomy era. We evaluated procedural and clinical outcomes of endovascular treatment for the ICAS (+)-LVO. We also compared their outcomes with those of large vessel occlusion not associated with intracranial atherosclerosis (ICAS [\u2212]-LVO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>We retrospectively reviewed consecutive patients with acute stroke who underwent endovascular treatment for LVO. Patients were assigned to the ICAS (+)-LVO group or the ICAS (\u2212)-LVO group primarily based on catheter angiogram. Procedural and clinical outcomes were compared between the ICAS (+)-LVO and ICAS (\u2212)-LVO groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>\n                      The present study included 318 patients. Fifty-six patients (17.6%) had an ICAS (+)-LVO. Recanalization was achieved in 45 patients in the ICAS (+)-LVO group (80.4%), which was comparable with the ICAS (\u2212)-LVO group (88.5%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.097). However, recanalization using a stent retriever was less successful in the ICAS (+)-LVO (28.9%) than the ICAS (\u2212)-LVO group (93.5%). Of the remaining patients in the ICAS (+)-LVO group, 84.3% of patients required specific rescue treatments appropriate for ICAS, including balloon angioplasty, stenting, and intra-arterial glycoprotein IIb\/IIIa inhibitor infusion. The rates of favorable outcomes (46.4% versus 46.9%), death, and symptomatic intracranial hemorrhage were not significantly different between the 2 groups. Glycoprotein IIb\/IIIa inhibitor use was not significantly associated with symptomatic intracranial hemorrhage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>ICAS (+)-LVO was often refractory to mechanical thrombectomy. With specific rescue treatments appropriate for ICAS, patients in the ICAS (+)-LVO group had a recanalization rate comparable with patients in the ICAS (\u2212)-LVO. With comparable recanalization rate, the clinical outcomes did not differ between patients with ICAS (+)-LVO and ICAS (\u2212)-LVO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.118.022327","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T05:14:56Z","timestamp":1539580496000},"page":"2699-2705","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":162,"title":["Outcomes of Endovascular Treatment for Acute Intracranial Atherosclerosis\u2013Related Large Vessel Occlusion"],"prefix":"10.1161","volume":"49","author":[{"given":"Jang-Hyun","family":"Baek","sequence":"first","affiliation":[{"name":"From the Department of Neurology, National Medical Center, Seoul, Republic of Korea (J.-H.B.)"},{"name":"Department of Neurology (J.-H.B., J.H.H., H.S.N., Y.D.K.), Severance Stroke Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Moon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Interventional Neuroradiology, Department of Radiology (B.M.K., D.J.K.), Severance Stroke Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hoe","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Neurology (J.-H.B., J.H.H., H.S.N., Y.D.K.), Severance Stroke Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Interventional Neuroradiology, Department of Radiology (B.M.K., D.J.K.), Severance Stroke Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Suk","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Neurology (J.-H.B., J.H.H., H.S.N., Y.D.K.), Severance Stroke Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Dae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology (J.-H.B., J.H.H., H.S.N., Y.D.K.), Severance Stroke Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.008781"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2014.16.1.27"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2016.12.2.129"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000158"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.9644"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.5469\/neuroint.2015.10.2.51"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2012-010395"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2015.01347"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003202"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.03.108"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.020072"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","unstructured":"Yang D Lin M Wang S Wang H Hao Y Zi W et al. 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