{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:14:47Z","timestamp":1792304087056,"version":"4.4.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Perinatal stroke causes most hemiparetic cerebral palsy and lifelong disability. Crossed cerebellar atrophy (CCA) is chronic cerebellar volume loss following contralateral motor pathway injury. We hypothesized that CCA is quantifiable in perinatal stroke and associated with poor motor outcome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Term-born children with perinatal stroke, magnetic resonance imaging beyond 6 months of age, and no additional neurological disorders were recruited. Blinded scorers measured cerebellar volumes expressed as ratios (contralesional\/ipsilesional), with values &lt;1 suggesting CCA. Motor outcomes including perinatal stroke outcome measure (PSOM) motor and cognitive scores (good\/poor), Assisting Hand Assessment, and Melbourne Assessment were compared with cerebellar volume measures.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Seventy-three children met criteria (53% male). Mean cerebellar ratios were &lt;1.0 (0.975\u00b10.04; range, 0.885\u20131.079;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) suggesting occurrence of CCA. Cerebellar ratios did not differ between stroke types or across PSOM motor outcomes. Larger ipsilesional cerebellar volume was associated with poor PSOM cognitive outcome (\n              <jats:italic>P<\/jats:italic>\n              =0.042), possibly with poor PSOM motor outcome (\n              <jats:italic>P<\/jats:italic>\n              =0.063), and overall PSOM score (\n              <jats:italic>P<\/jats:italic>\n              =0.034).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>CCA occurs in perinatal stroke but is not strongly associated with motor outcome. However, ipsilesional cerebellar volume is associated with poor cognitive and overall outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.118.022423","type":"journal-article","created":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T19:00:57Z","timestamp":1545678057000},"page":"175-177","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Crossed Cerebellar Atrophy in Perinatal Stroke"],"prefix":"10.1161","volume":"50","author":[{"given":"Brandon T.","family":"Craig","sequence":"first","affiliation":[{"name":"From the Calgary Pediatric Stroke Program (B.T.C., C.O., S.M., H.L.C., A.K.), Cumming School of Medicine, University of Calgary, AB, Canada"},{"name":"Hotchkiss Brain Institute (B.T.C., H.L.C., A.K.), Cumming School of Medicine, University of Calgary, AB, Canada"},{"name":"Department of Pediatrics (B.T.C., H.L.C., A.K.), Cumming School of Medicine, University of Calgary, AB, Canada"},{"name":"Alberta Children\u2019s Hospital Research Institute, University of Calgary, Canada (B.T.C., H.L.C., A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheyanne","family":"Olsen","sequence":"additional","affiliation":[{"name":"From the Calgary Pediatric Stroke Program (B.T.C., C.O., S.M., H.L.C., A.K.), Cumming School of Medicine, University of Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Mah","sequence":"additional","affiliation":[{"name":"From the Calgary Pediatric Stroke Program (B.T.C., C.O., S.M., H.L.C., A.K.), Cumming School of Medicine, University of Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen L.","family":"Carlson","sequence":"additional","affiliation":[{"name":"From the Calgary Pediatric Stroke Program (B.T.C., C.O., S.M., H.L.C., A.K.), Cumming School of Medicine, University of Calgary, AB, Canada"},{"name":"Hotchkiss Brain Institute (B.T.C., H.L.C., A.K.), Cumming School of Medicine, University of Calgary, AB, Canada"},{"name":"Department of Pediatrics (B.T.C., H.L.C., A.K.), Cumming School of Medicine, University of Calgary, AB, Canada"},{"name":"Alberta Children\u2019s Hospital Research Institute, University of Calgary, Canada (B.T.C., H.L.C., A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Chang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Radiology (A.K., X.-C.W.), Cumming School of Medicine, University of Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Kirton","sequence":"additional","affiliation":[{"name":"From the Calgary Pediatric Stroke Program (B.T.C., C.O., S.M., H.L.C., A.K.), Cumming School of Medicine, University of Calgary, AB, Canada"},{"name":"Hotchkiss Brain Institute (B.T.C., H.L.C., A.K.), Cumming School of Medicine, University of Calgary, AB, Canada"},{"name":"Department of Pediatrics (B.T.C., H.L.C., A.K.), Cumming School of Medicine, University of Calgary, AB, Canada"},{"name":"Department of Radiology (A.K., X.-C.W.), Cumming School of Medicine, University of Calgary, AB, Canada"},{"name":"Department of Clinical Neurosciences (A.K.), Cumming School of Medicine, University of Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.000739"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21334"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1073858404270843"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2007.05.011"},{"key":"e_1_3_4_6_2","volume-title":"Localization in the Cerebrum and Reduction of Function by Cortical Foci","author":"von Monakow C","year":"1914","unstructured":"von Monakow, C. Localization in the Cerebrum and Reduction of Function by Cortical Foci. Wiesbaden, Germany; 1914."},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.158.5.1566683"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000744"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493016666089"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.639583"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/108.4.881"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00279670"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968316680485"},{"key":"e_1_3_4_14_2","first-page":"14","article-title":"Crossed-cerebellar diaschisis in cerebral infarction: technetium-99m-HMPAO SPECT and MRI.","volume":"38","author":"Kim SE","year":"1997","unstructured":"Kim, SE, Choi, CW, Yoon, BW, Chung, JK, Roh, JH, Lee, MC, et al. Crossed-cerebellar diaschisis in cerebral infarction: technetium-99m-HMPAO SPECT and MRI. J Nucl Med. 1997;38:14\u201319.","journal-title":"J Nucl Med"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.118.022423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:59:05Z","timestamp":1715612345000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.118.022423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1161\/STROKEAHA.118.022423"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.118.022423","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"2018-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}