{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:23:52Z","timestamp":1790223832563,"version":"4.1.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Hemispheric stroke studies associating lateropulsion (pusher syndrome) with the location of brain lesions have had mixed results from small, unmatched samples. This study was designed to determine whether lateropulsion localizes to specific brain regions across patients with stroke using a case-control design.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Fifty patients with lateropulsion after stroke were matched with 50 stroke patients without lateropulsion using age, time since onset of stroke, admission motor Functional Independence Measure score, lesion side, and gender. The primary analysis included multivariate lesion symptom mapping using sparse canonical correlations to identify regions most associated with lateropulsion as assessed with the Burke Lateropulsion Scale. Secondary analyses included evaluating paired comparisons for lesion volume, degree of motor impairment, motor and cognitive Functional Independence Measure scores.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              The lesion symptom mapping analysis of all lesions mapped onto a common hemisphere produced an overall significant model (\n              <jats:italic>P<\/jats:italic>\n              &lt;5\u00d710\n              <jats:sup>\u20135<\/jats:sup>\n              ) with a regional peak at the inferior parietal lobe at the junction of the post-central gyrus (Brodmann Area 2) and Brodmann Area 40 as the lesion location most associated with lateropulsion. Lesion volume was larger for patients with lateropulsion. Despite adequate matching, motor performance and total Functional Independence Measure scores differed at a group level between patients with and without lateropulsion.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>This analysis implicated lesion involvement of the inferior parietal lobe as a key neuroanatomical determinant of developing lateropulsion. A better understanding of the anatomic underpinnings of lateropulsion may improve rehabilitation efforts, including the potential for informing noninvasive neuromodulation approaches.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.118.023445","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T09:01:59Z","timestamp":1555318919000},"page":"1067-1073","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["Lesion Localization of Poststroke Lateropulsion"],"prefix":"10.1161","volume":"50","author":[{"given":"Suzanne R.","family":"Babyar","sequence":"first","affiliation":[{"name":"From the Department of Physical Therapy, Hunter College, The City University of New York, NY (S.R.B.)"},{"name":"Neurology, Stroke Unit, Burke Rehabilitation Hospital, White Plains, NY (S.R.B., M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Smeragliuolo","sequence":"additional","affiliation":[{"name":"Department of Telemedicine and Virtual Rehabilitation, Burke Medical Research Institute, White Plains, NY (A.S., D.P.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatimah M.","family":"Albazron","sequence":"additional","affiliation":[{"name":"Iowa Neuroimaging and Noninvasive Brain Stimulation Laboratory, Departments of Pediatrics, Neurology &amp; Psychiatry, University of Iowa Hospitals and Clinics, Iowa City (F.M.A., A.D.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Putrino","sequence":"additional","affiliation":[{"name":"Department of Telemedicine and Virtual Rehabilitation, Burke Medical Research Institute, White Plains, NY (A.S., D.P.)"},{"name":"Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY (D.P.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Reding","sequence":"additional","affiliation":[{"name":"Neurology, Stroke Unit, Burke Rehabilitation Hospital, White Plains, NY (S.R.B., M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron D.","family":"Boes","sequence":"additional","affiliation":[{"name":"Iowa Neuroimaging and Noninvasive Brain Stimulation Laboratory, Departments of Pediatrics, Neurology &amp; Psychiatry, University of Iowa Hospitals and Clinics, Iowa City (F.M.A., A.D.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-96833-4"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968307313511"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(96)90215-4"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000147724.83468.18"},{"key":"e_1_3_4_6_2","first-page":"143","article-title":"Pusher syndrome in stroke: clinical, neuropsychological and neurophysiological investigation.","volume":"37","author":"Premoselli S","year":"2001","unstructured":"Premoselli, S, Cesana, L, Cerri, C. 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