{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:53:02Z","timestamp":1790041982237,"version":"4.0.1"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Carotid artery stenting in tandem large vessel occlusion strokes is usually avoided because of the intracranial hemorrhagic risks induced by antiplatelet therapy during thrombectomy interventions. This study aimed to evaluate the incidence of hemorrhagic transformation following thrombectomy in large vessel occlusion strokes patients with atherosclerotic cervical carotid occlusion, associated factors, and clinical relevance.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>The TITAN (Thrombectomy in Tandem Lesions) collaboration pooled individual data of prospectively collected multicentric thrombectomy databases for consecutive anterior circulation tandem large vessel occlusion strokes patients who underwent thrombectomy. Hemorrhagic infarction (HI) and parenchymal hematoma (PH) were assessed within 24 hours.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Among 289 patients with atherosclerotic cause, 66 (24.7%) patients developed HI and 38 (14.2%) PH. Intracranial carotid occlusion, diabetes mellitus, absence of prior intravenous thrombolysis, and complete extracranial carotid occlusion were independent predictors of HI. Similar predictors were found for PH with addition of higher baseline National Institutes of Health Stroke Scale and Alberta Stroke Program Early CT Score &lt;7. No detrimental effect of HI on 90-day clinical outcome was found. The occurrence of PH was associated with increased mortality rates (adjusted odds ratio, 2.63; 95% CI, 1.05\u20136.59;\n              <jats:italic>P<\/jats:italic>\n              =0.039) and had no detrimental effect on 90-day modified Rankin Scale 0 to 2 (adjusted odds ratio, 0.52; 95% CI, 0.20\u20131.28;\n              <jats:italic>P<\/jats:italic>\n              =0.25).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Incidence of PH after tandem large vessel occlusion strokes thrombectomy is equivalent to those reported in the literature data for isolated occlusions. Similar predictors were found for PH and HI within 24 hours, whereas acute carotid artery stenting and antiplatelet therapy were not, suggesting an aggressive endovascular treatment of tandem occlusions.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.118.023689","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T14:01:41Z","timestamp":1547560901000},"page":"516-519","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":60,"title":["Hemorrhagic Transformation After Thrombectomy for Tandem Occlusions"],"prefix":"10.1161","volume":"50","author":[{"given":"Fran\u00e7ois","family":"Zhu","sequence":"first","affiliation":[{"name":"From the Department of Diagnostic and Therapeutic Neuroradiology, INSERM U1254 (F.Z., S.B., B.G.), University Hospital of Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Labreuche","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, EA 2694\u2013Sant\u00e9 Publique: Epid\u00e9miologie et Qualit\u00e9 des Soins, CHRU Lille, France (J.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo C.","family":"Haussen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emory University\/Grady Memorial Hospital, Atlanta, GA (D.C.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Piotin","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Paris, France (M.P., M.M.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Steglich-Arnholm","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rigshospitalet, Copenhagen, Denmark (H.S.-A.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Taschner","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.A.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Papanagiotou","sequence":"additional","affiliation":[{"name":"Diagnostic and Interventional Neuroradiology, Hospital Bremen-Mitte\/Bremen-Ost, Deutschland (P.P.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Lapergue","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Center, Foch Hospital, Suresnes, France (B.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Dorn","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital of Munich, Germany (F.D.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Cognard","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital of Toulouse, France (C.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Killer","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Paracelsus Medical University Salzburg, Austria (M.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios N.","family":"Psychogios","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Medical Center G\u00f6ttingen, Germany (M.P.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Spiotta","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University of South Carolina, Charleston (A.M.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Mazighi","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Paris, France (M.P., M.M.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Bracard","sequence":"additional","affiliation":[{"name":"From the Department of Diagnostic and Therapeutic Neuroradiology, INSERM U1254 (F.Z., S.B., B.G.), University Hospital of Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Turjman","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (F.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Richard","sequence":"additional","affiliation":[{"name":"Stroke Unit, CIC-P 1433, INSERM U1116, Department of Neurology (S.R.), University Hospital of Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Gory","sequence":"additional","affiliation":[{"name":"From the Department of Diagnostic and Therapeutic Neuroradiology, INSERM U1254 (F.Z., S.B., B.G.), University Hospital of Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the TITAN (Thrombectomy in Tandem Lesions) Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2017-013316"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13577"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2013-010743"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.05.036"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018264"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.118.023689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:01:54Z","timestamp":1715612514000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.118.023689"}},"subtitle":["Incidence, Predictors, and Clinical Implications"],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1161\/STROKEAHA.118.023689"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.118.023689","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"2018-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}