{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:22:06Z","timestamp":1791534126837,"version":"4.3.4"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,5]]},"abstract":"\n Background and Purpose\u2014<\/jats:title>\n Infratentorial intracerebral hemorrhage (ICH) has a poor outcome but is rarely analyzed by cerebellar versus brain stem location. We evaluated this relationship and clinical outcomes among participants of the INTERACT 1 and 2 (Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials).<\/jats:p>\n <\/jats:sec>\n \n Methods\u2014<\/jats:title>\n Participants with brain stem and cerebellar ICH were compared. Logistic regression models were used to compare outcomes of death or major disability and quality of life.<\/jats:p>\n <\/jats:sec>\n \n Results\u2014<\/jats:title>\n Of 195 included patients, 92 (47%) and 103 (53%) had brain stem and cerebellar ICH, respectively. Patients with brain stem ICH were younger (mean [SD] age, 59\u00b113 versus 70\u00b111 years), less female (28.3% versus 50.5%), with higher admission National Institutes of Health Stroke Scale scores (median [interquartile range], 6 [4\u201310) versus 3 [2\u20138]), less prior ICH (3% versus 17%), smaller ICH volumes (1.6 mL [1.0\u20132.8 mL] versus 5.1 mL [2.6\u201310.7 mL]), and less intraventricular extension (3% versus 39%) than those with cerebellar ICH. Brain stem ICH had higher mortality (odds ratio, 37.1; 95% CI, 1.99\u2013692.27) and worse scores in the European Quality of Life Scale (EQ-5D) pain domain (odds ratio, 3.36; 95% CI, 1.38\u20138.20).<\/jats:p>\n <\/jats:sec>\n \n Conclusions\u2014<\/jats:title>\n Cerebellar and brain stem ICH differ in their clinical characteristics and prognosis, with the latter being associated with higher case fatality and worse EQ-5D scores in the pain domain.<\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration\u2014<\/jats:title>\n \n URL:\n https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n . Unique identifiers: NCT00226096 and NCT00716079.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/strokeaha.118.023766","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T09:00:28Z","timestamp":1553072428000},"page":"1257-1259","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["Infratentorial Intracerebral Hemorrhage"],"prefix":"10.1161","volume":"50","author":[{"given":"Ruiqi","family":"Chen","sequence":"first","affiliation":[{"name":"From the Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu (R.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia (X.W., C.S.A., R.I.L., J.C., C.D.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig S.","family":"Anderson","sequence":"additional","affiliation":[{"name":"George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia (X.W., C.S.A., R.I.L., J.C., C.D.)"},{"name":"George Institute China at Peking University Medical Science Center, Beijing (C.S.A.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thompson","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences and National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, University of Leicester, United Kingdom (T.R.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo M.","family":"Lavados","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Neurol\u00f3gicas, Facultad de Medicina, Universidad de Chile, Santiago (P.M.L.)"},{"name":"Unidad de Neurolog\u00eda Vascular, Servicio de Neurolog\u00eda, Departamento de Neurolog\u00eda y Psiquiatr\u00eda, Cl\u00ednica Alemana de Santiago, Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile (P.M.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard I.","family":"Lindley","sequence":"additional","affiliation":[{"name":"George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia (X.W., C.S.A., R.I.L., J.C., C.D.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Chalmers","sequence":"additional","affiliation":[{"name":"George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia (X.W., C.S.A., R.I.L., J.C., C.D.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice","family":"Delcourt","sequence":"additional","affiliation":[{"name":"George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia (X.W., C.S.A., R.I.L., J.C., C.D.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the INTERACT Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105103441907"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003771"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1309586"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70069-3"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007953"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2008.2964"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000093825.04365.F3"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.538967"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(89)90128-0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1100-05.2005"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.118.023766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:50:31Z","timestamp":1715611831000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.118.023766"}},"subtitle":["Relation of Location to Outcome"],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1161\/STROKEAHA.118.023766"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.118.023766","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"2018-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}