{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:42:19Z","timestamp":1772109739613,"version":"3.50.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Predicting long-term functional outcomes after intracranial aneurysmal rupture can be challenging. We developed and validated a scoring system\u2014the Southwestern Aneurysm Severity Index\u2014that would predict functional outcomes at 1 year after clipping of ruptured aneurysms.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Ruptured aneurysms treated microsurgically between 2000 and 2014 were included. Outcome was defined as Glasgow Outcome Score (ranging from 1, death, to 5, good recovery) at 1 year. The Southwestern Aneurysm Severity Index is composed of multiple prospectively recorded patient demographic, clinical, radiographic, and aneurysm-specific variables. Multivariable analyses were used to construct the best predictive models for patient outcomes in a random 50% of the cohort and validated in the remaining 50%. A scoring system was created using the best model.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              We identified 527 eligible patients. The Glasgow Outcome Score at 1 year was 4 to 5 in 375 patients (71.2%). In the multivariable logistic regression, the best predictive model for unfavorable outcome included intracerebral hemorrhage (odds ratio [OR], 2.53; 95% CI, 1.55\u22124.13), aneurysmal size \u226520 mm (OR, 6.07; 95% CI, 1.92\u221219.2), intraventricular hemorrhage (OR, 2.56; 95% CI, 1.15\u22125.67), age &gt;64 (OR, 3.53; 95% CI, 1.70\u22127.35), location (OR, 1.82; 95% CI, 1.10\u22123.03), and hydrocephalus (OR, 2.39; 95% CI, 1.07\u22125.35). The Southwestern Aneurysm Severity Index predicts Glasgow Outcome Score at 1 year with good discrimination (area under the receiver operating characteristic curve, derivation: 0.816, 95% CI, 0.759\u22120.873; validation: 0.803, 95% CI, 0.746\u22120.861) and accurate calibration (\n              <jats:italic>R<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =0.939).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The Southwestern Aneurysm Severity Index has been internally validated to predict 1 year Glasgow Outcome Scores at initial presentation, thus optimizing patient or family counseling and possibly guiding therapeutic efforts.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.118.023771","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T10:01:07Z","timestamp":1550570467000},"page":"595-601","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Prediction of Outcomes for Ruptured Aneurysm Surgery"],"prefix":"10.1161","volume":"50","author":[{"given":"Vin Shen","family":"Ban","sequence":"first","affiliation":[{"name":"From the Department of Neurological Surgery (V.S.B., T.Y.E.A., S.G.A., A.R.P., K.A.L., C.E., J.B., C.M.M., B.G.W., D.S., H.H.B., J.W.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek Y.","family":"El Ahmadieh","sequence":"additional","affiliation":[{"name":"From the Department of Neurological Surgery (V.S.B., T.Y.E.A., S.G.A., A.R.P., K.A.L., C.E., J.B., C.M.M., B.G.W., D.S., H.H.B., J.W.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salah G.","family":"Aoun","sequence":"additional","affiliation":[{"name":"From the Department of Neurological Surgery (V.S.B., T.Y.E.A., S.G.A., A.R.P., K.A.L., C.E., J.B., C.M.M., B.G.W., D.S., H.H.B., J.W.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron R.","family":"Plitt","sequence":"additional","affiliation":[{"name":"From the Department of Neurological Surgery (V.S.B., T.Y.E.A., S.G.A., A.R.P., K.A.L., C.E., J.B., C.M.M., B.G.W., D.S., H.H.B., J.W.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristopher A.","family":"Lyon","sequence":"additional","affiliation":[{"name":"From the Department of Neurological Surgery (V.S.B., T.Y.E.A., S.G.A., A.R.P., K.A.L., C.E., J.B., C.M.M., B.G.W., D.S., H.H.B., J.W.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Eddleman","sequence":"additional","affiliation":[{"name":"From the Department of Neurological Surgery (V.S.B., T.Y.E.A., S.G.A., A.R.P., K.A.L., C.E., J.B., C.M.M., B.G.W., D.S., H.H.B., J.W.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Beecher","sequence":"additional","affiliation":[{"name":"From the Department of Neurological Surgery (V.S.B., T.Y.E.A., S.G.A., A.R.P., K.A.L., C.E., J.B., C.M.M., B.G.W., D.S., H.H.B., J.W.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron M.","family":"McDougall","sequence":"additional","affiliation":[{"name":"From the Department of Neurological Surgery (V.S.B., T.Y.E.A., S.G.A., A.R.P., K.A.L., C.E., J.B., C.M.M., B.G.W., D.S., H.H.B., J.W.), University of Texas Southwestern Medical Center, Dallas."},{"name":"Department of Radiology (C.M.M., B.G.W.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Reisch","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences (J.R.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babu G.","family":"Welch","sequence":"additional","affiliation":[{"name":"From the Department of Neurological Surgery (V.S.B., T.Y.E.A., S.G.A., A.R.P., K.A.L., C.E., J.B., C.M.M., B.G.W., D.S., H.H.B., J.W.), University of Texas Southwestern Medical Center, Dallas."},{"name":"Department of Radiology (C.M.M., B.G.W.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duke","family":"Samson","sequence":"additional","affiliation":[{"name":"From the Department of Neurological Surgery (V.S.B., T.Y.E.A., S.G.A., A.R.P., K.A.L., C.E., J.B., C.M.M., B.G.W., D.S., H.H.B., J.W.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Hunt","family":"Batjer","sequence":"additional","affiliation":[{"name":"From the Department of Neurological Surgery (V.S.B., T.Y.E.A., S.G.A., A.R.P., K.A.L., C.E., J.B., C.M.M., B.G.W., D.S., H.H.B., J.W.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"White","sequence":"additional","affiliation":[{"name":"From the Department of Neurological Surgery (V.S.B., T.Y.E.A., S.G.A., A.R.P., K.A.L., C.E., J.B., C.M.M., B.G.W., D.S., H.H.B., J.W.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052732"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182587839"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000035748.91128.C2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70017-5"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dd42b3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003353"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12006"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.191395"},{"key":"e_1_3_3_10_2","first-page":"209","article-title":"The etiology of recurrent ocular paralysis (including periodic ocular paralysis and ophthalmoplegic migraine).","volume":"40","author":"Bramwell E","year":"1933","unstructured":"Bramwell, E. 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