{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:52:02Z","timestamp":1784116322936,"version":"3.55.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Open-cell carotid artery stents are associated with a higher peri-procedural stroke risk than closed-cell stents. However, the effect of stent design on long-term durability of carotid artery stenting (CAS) is unknown. We compared the medium- to long-term risk of restenosis and ipsilateral stroke between patients treated with open-cell stents versus closed-cell stents in the ICSS (International Carotid Stenting Study).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Patients with symptomatic carotid stenosis were randomized to CAS or endarterectomy and followed with duplex ultrasound for a median of 4.0 years. We analyzed data from patients with completed CAS procedures, known stent design, and available ultrasound follow-up. The primary outcome, moderate or higher restenosis (\u226550%) was defined as a peak systolic velocity of &gt;1.3 m\/s on ultrasound or occlusion of the treated internal carotid artery and analyzed with interval-censored models.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Eight hundred fifty-five patients were allocated to CAS. Seven hundred fourteen patients with completed CAS and known stent design were included in the current analysis. Of these, 352 were treated with open-cell and 362 with closed-cell stents. Moderate or higher restenosis occurred significantly less frequently in patients treated with open-cell (n=113) than closed-cell stents (n=154; 5-year risks were 35.5% versus 46.0%; unadjusted hazard ratio, 0.68; 95% CI, 0.53\u20130.88). There was no significant difference in the risk of severe restenosis (\u226570%) after open-cell stenting (n=27) versus closed-cell stenting (n=43; 5-year risks, 8.6% versus 12.7%; unadjusted hazard ratio, 0.63; 95% CI, 0.37\u20131.05). The risk of ipsilateral stroke beyond 30 days after treatment was similar with open-cell and closed-cell stents (hazard ratio, 0.78; 95% CI, 0.35\u20131.75).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Moderate or higher restenosis after CAS occurred less frequently in patients treated with open-cell stents than closed-cell stents. However, both stent designs were equally effective at preventing recurrent stroke during follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.isrctn.com\/\">http:\/\/www.isrctn.com\/<\/jats:ext-link>\n              . Unique identifier: ISRCTN25337470.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.118.024076","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T09:00:22Z","timestamp":1569315622000},"page":"3013-3020","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":49,"title":["Stent Design, Restenosis and Recurrent Stroke After Carotid Artery Stenting in the International Carotid Stenting Study"],"prefix":"10.1161","volume":"50","author":[{"given":"Mandy D.","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"From the Department of Neurology and Stroke Center (M.D.M., S.T.E., P.A.L., L.H.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gregson","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, London School of Hygiene and Tropical Medicine, United Kingdom (J.G.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominick J.H.","family":"McCabe","sequence":"additional","affiliation":[{"name":"Vascular Neurology Research Foundation, Department of Neurology and Stroke Service, The Adelaide and Meath Hospital, Dublin, incorporating the National Children\u2019s Hospital, Dublin\/Tallaght University Hospital, Ireland; Irish Center for Vascular Biology, Ireland; Academic Unit of Neurology, School of Medicine, Trinity College Dublin, Ireland (D.J.H.M.)"},{"name":"Department of Clinical Neurosciences, Royal Free Campus (D.J.H.M.), UCL Institute of Neurology, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Nederkoorn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Amsterdam University Medical Center, the Netherlands (P.J.N.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Bart","family":"van der Worp","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus (H.B.v.d.W.), University Medical Center Utrecht, Utrecht University, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert J.","family":"de Borst","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery (G.J.d.B.), University Medical Center Utrecht, Utrecht University, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Cleveland","sequence":"additional","affiliation":[{"name":"Sheffield Vascular Institute, Sheffield Teaching Hospitals NHS Foundation Trust, United Kingdom (T.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wolff","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery (T.W.), University of Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan T.","family":"Engelter","sequence":"additional","affiliation":[{"name":"From the Department of Neurology and Stroke Center (M.D.M., S.T.E., P.A.L., L.H.B.)"},{"name":"University Hospital Basel and Neurorehabilitation Unit, University Center for Medicine of Aging and Rehabilitation Basel, Felix Platter Hospital (S.T.E.), University of Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe A.","family":"Lyrer","sequence":"additional","affiliation":[{"name":"From the Department of Neurology and Stroke Center (M.D.M., S.T.E., P.A.L., L.H.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin M.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo H.","family":"Bonati","sequence":"additional","affiliation":[{"name":"From the Department of Neurology and Stroke Center (M.D.M., S.T.E., P.A.L., L.H.B.)"},{"name":"Stroke Research Center, Department of Brain Repair and Rehabilitation (L.H.B.), UCL Institute of Neurology, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"For the International Carotid Stenting Study Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61009-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61184-3"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505215"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70196-0"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70159-X"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005671"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30195-9"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2015.08.013"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.09.019"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.534289"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2011.01.450"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(07)61620-0"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000078753"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60239-5"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.6.711"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70227-3"},{"key":"e_1_3_3_18_2","first-page":"286","volume-title":"Modelling Survival Data In Medical Research","author":"Collet D","year":"2003","unstructured":"Collet, D. Modelling Survival Data In Medical Research. London: Chapman & Hall\/CRC; 2003:286\u2013296."},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2017-013622"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.10.016"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/2396987316678361"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2003.12.029"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.589309"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912321"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.118.024076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:12:00Z","timestamp":1715613120000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.118.024076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1161\/STROKEAHA.118.024076"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.118.024076","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"2018-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}