{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:24:26Z","timestamp":1787761466594,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Hypoperfusion intensity ratio (HIR) is associated with collateral status in acute ischemic stroke patients with anterior circulation large vessel occlusion. We assessed whether HIR was correlated to patient eligibility for mechanical thrombectomy (MT).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>We performed a retrospective cohort study of consecutive acute ischemic stroke patients with a proximal middle cerebral artery or internal carotid artery occlusion who underwent MT triage with computed tomography or magnetic resonance perfusion imaging. Clinical data, ischemic core (mL), HIR (defined as time-to-maximum [TMax] &gt;10 seconds\/TMax &gt;6 seconds), mismatch volume between core and penumbra, and MT details were assessed. Primary outcome was favorable HIR collateral score (HIR &lt;0.4) between patients who underwent MT (MT+) and those who did not (MT\u2212) according to American Heart Association guidelines both in the &lt;6 hours and 6 to 24 hours windows. Secondary outcomes were favorable HIR score in MT\u2212 subgroups (National Institutes of Health Stroke Scale &lt;6 versus core &gt;70 mL) and core-penumbra mismatch volumes. Patients who did not meet guidelines were not included.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              We included 197 patients (145 MT+ and 52 MT\u2212). MT+ patients had a significantly lower median HIR compared with MT\u2212 patients (0.4 [interquartile range, 0.2\u20130.5] versus 0.6 [interquartile range, 0.5\u20130.8];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and a higher mismatch volume (96 versus 27 mL,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Among MT\u2212 patients, 43 had a core &gt;70 mL, and 9 had a National Institutes of Health Stroke Scale &lt;6. MT\u2212 patients with National Institutes of Health Stroke Scale &lt;6 had a lower HIR than MT\u2212 patients with core &gt;70 mL (0.2 [interquartile range, 0.2\u20130.3] versus 0.7 [interquartile range, 0.6\u20130.8],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) but their HIR was not significantly different that MT+ patients.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Patients who meet American Heart Association guidelines for thrombectomy are more likely to have favorable collaterals (low HIR). HIR may be used as a marker of eligibility for MT triage.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.118.024134","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T10:00:31Z","timestamp":1551952831000},"page":"917-922","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":99,"title":["Hypoperfusion Intensity Ratio Is Correlated With Patient Eligibility for Thrombectomy"],"prefix":"10.1161","volume":"50","author":[{"given":"Adrien","family":"Guenego","sequence":"first","affiliation":[{"name":"From the Department of Radiology, Neuroimaging and Neurointervention Section, Stanford Medical Center, CA (A.G., D.G.M., B.W.M, M.P.M., M.W., J.J.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Marcellus","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Neuroimaging and Neurointervention Section, Stanford Medical Center, CA (A.G., D.G.M., B.W.M, M.P.M., M.W., J.J.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake W.","family":"Martin","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Neuroimaging and Neurointervention Section, Stanford Medical Center, CA (A.G., D.G.M., B.W.M, M.P.M., M.W., J.J.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soren","family":"Christensen","sequence":"additional","affiliation":[{"name":"Stanford Stroke Center, Stanford University School of Medicine, CA (S.C., G.W.A., M.G.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W.","family":"Albers","sequence":"additional","affiliation":[{"name":"Stanford Stroke Center, Stanford University School of Medicine, CA (S.C., G.W.A., M.G.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten G.","family":"Lansberg","sequence":"additional","affiliation":[{"name":"Stanford Stroke Center, Stanford University School of Medicine, CA (S.C., G.W.A., M.G.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Marks","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Neuroimaging and Neurointervention Section, Stanford Medical Center, CA (A.G., D.G.M., B.W.M, M.P.M., M.W., J.J.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Wintermark","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Neuroimaging and Neurointervention Section, Stanford Medical Center, CA (A.G., D.G.M., B.W.M, M.P.M., M.W., J.J.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy J.","family":"Heit","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Neuroimaging and Neurointervention Section, Stanford Medical Center, CA (A.G., D.G.M., B.W.M, M.P.M., M.W., J.J.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000158"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411587"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414792"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1508744"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713973"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.10.020"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003857"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.526954"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17740293"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25320"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.77"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000335929.06390.d3"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2017-013492"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493017701942"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.118.024134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:32:52Z","timestamp":1715614372000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.118.024134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1161\/STROKEAHA.118.024134"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.118.024134","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"2018-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}