{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:58:05Z","timestamp":1790384285677,"version":"4.1.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>We investigated the prognostic significance of spontaneous intracerebral hemorrhage location in presence of severe intraventricular hemorrhage.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>We analyzed diagnostic computed tomography scans from 467\/500 (excluding primary intraventricular hemorrhage) subjects from the CLEAR (Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage) III trial. We measured intracerebral hemorrhage engagement with specific anatomic regions, and estimated association of each region with blinded assessment of dichotomized poor stroke outcomes: mortality, modified Rankin Scale score of 4 to 6, National Institutes of Health Stroke Scale score of &gt;4, stroke impact scale score of &lt;60, Barthel Index &lt;86, and EuroQol visual analogue scale score of &lt;50 and &lt;70 at days 30 and 180, respectively, using logistic regression models.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Frequency of anatomic region involvement consisted of thalamus (332 lesions, 71.1% of subjects), caudate (219, 46.9%), posterior limb internal capsule (188, 40.3%), globus pallidus\/putamen (127, 27.2%), anterior limb internal capsule (108, 23.1%), and lobar (29, 6.2%). Thalamic location was independently associated with mortality (days 30 and 180) and with poor outcomes on most stroke scales at day 180 on adjusted analysis. Posterior limb internal capsule and globus pallidus\/putamen involvement was associated with increased odds of worse disability at days 30 and 180. Anterior limb internal capsule and caudate locations were associated with decreased mortality on days 30 and 180. Anterior limb internal capsule lesions were associated with decreased long-term morbidity.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Acute intracerebral hemorrhage lesion topography provides important insights into anatomic correlates of mortality and functional outcomes even in severe intraventricular hemorrhage causing obstructive hydrocephalus. Models accounting for intracerebral hemorrhage location in addition to volumes may improve outcome prediction and permit stratification of benefit from aggressive acute interventions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00784134.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.118.024187","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T09:01:18Z","timestamp":1560157278000},"page":"1688-1695","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["Influence of Intracerebral Hemorrhage Location on Outcomes in Patients With Severe Intraventricular Hemorrhage"],"prefix":"10.1161","volume":"50","author":[{"given":"Vahid","family":"Eslami","sequence":"first","affiliation":[{"name":"From the Division of Neurosciences Critical Care, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD (V.E., P.T.-F., L.R.-L., D.F.H., W.C.Z.)"},{"name":"Division of Brain Injury Outcomes, Department of Neurology, Johns Hopkins University, Baltimore, MD (V.E., P.T.-F., L.R.-L., H.A., S.N.-T., R.D., N.M., D.F.H., W.C.Z.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouya","family":"Tahsili-Fahadan","sequence":"additional","affiliation":[{"name":"From the Division of Neurosciences Critical Care, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD (V.E., P.T.-F., L.R.-L., D.F.H., W.C.Z.)"},{"name":"Division of Brain Injury Outcomes, Department of Neurology, Johns Hopkins University, Baltimore, MD (V.E., P.T.-F., L.R.-L., H.A., S.N.-T., R.D., N.M., D.F.H., W.C.Z.)"},{"name":"Neuroscience Intensive Care Unit, Department of Neurology, Virginia Commonwealth University, Falls Church (P.T.-F.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Rivera-Lara","sequence":"additional","affiliation":[{"name":"From the Division of Neurosciences Critical Care, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD (V.E., P.T.-F., L.R.-L., D.F.H., W.C.Z.)"},{"name":"Division of Brain Injury Outcomes, Department of Neurology, Johns Hopkins University, Baltimore, MD (V.E., P.T.-F., L.R.-L., H.A., S.N.-T., R.D., N.M., D.F.H., W.C.Z.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dheeraj","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of Maryland, Baltimore (D.G.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Ali","sequence":"additional","affiliation":[{"name":"Division of Brain Injury Outcomes, Department of Neurology, Johns Hopkins University, Baltimore, MD (V.E., P.T.-F., L.R.-L., H.A., S.N.-T., R.D., N.M., D.F.H., W.C.Z.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Parry-Jones","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Manchester, Manchester Academic Health Sciences Centre, Salford Royal NHS Foundation Trust, United Kingdom (A.P.-J., L.S.N.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilli S.","family":"Nelson","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Manchester, Manchester Academic Health Sciences Centre, Salford Royal NHS Foundation Trust, United Kingdom (A.P.-J., L.S.N.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (R.E.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Nekoobakht-Tak","sequence":"additional","affiliation":[{"name":"Division of Brain Injury Outcomes, Department of Neurology, Johns Hopkins University, Baltimore, MD (V.E., P.T.-F., L.R.-L., H.A., S.N.-T., R.D., N.M., D.F.H., 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Neurosciences Critical Care, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD (V.E., P.T.-F., L.R.-L., D.F.H., W.C.Z.)"},{"name":"Division of Brain Injury Outcomes, Department of Neurology, Johns Hopkins University, Baltimore, MD (V.E., P.T.-F., L.R.-L., H.A., S.N.-T., R.D., N.M., D.F.H., W.C.Z.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy C.","family":"Ziai","sequence":"additional","affiliation":[{"name":"From the Division of Neurosciences Critical Care, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD (V.E., P.T.-F., L.R.-L., D.F.H., W.C.Z.)"},{"name":"Division of Brain Injury Outcomes, Department of Neurology, Johns Hopkins University, Baltimore, MD (V.E., P.T.-F., L.R.-L., H.A., S.N.-T., R.D., N.M., D.F.H., W.C.Z.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the CLEAR III 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