{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:10:15Z","timestamp":1789909815603,"version":"4.0.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Cortical cerebral microinfarcts (CMIs) have been associated with vascular dementia and Alzheimer disease. The aim of the present study was to evaluate the role of cortical CMI detected on 3T magnetic resonance imaging, on the evolution of cognition during the year following an acute ischemic stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>We conducted a prospective and monocentric study, including patients diagnosed for a supratentorial ischemic stroke with a National Institutes of Health Stroke Scale score \u22651, without prestroke dementia or neurological disability. Cortical CMIs were assessed on a brain 3T magnetic resonance imaging realized at baseline, as well as markers of small vessel disease, stroke characteristics, and hippocampal atrophy. Cognitive assessment was performed at 3 time points (baseline, 3 months, and 1 year) using the Montreal Cognitive Assessment, the Isaacs set test, and the Zazzo\u2019s cancellation task. Generalized linear mixed models were performed to evaluate the relationships between the number of cortical CMI and changes in cognitive scores over 1 year.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Among 199 patients (65\u00b113 years old, 68% men), 88 (44%) had at least one cortical CMI. Hypertension was the main predictor of a higher cortical CMI load (B=0.58,\n              <jats:italic>P<\/jats:italic>\n              =0.005). The number of cortical CMI was associated with an increase time at the Zazzo\u2019s cancellation task over 1 year (B=3.84,\n              <jats:italic>P<\/jats:italic>\n              =0.01), regardless of the other magnetic resonance imaging markers, stroke severity, and demographic factors.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Cortical CMIs are additional magnetic resonance imaging markers of poorer processing speed after ischemic stroke. These results indicate that a high load of cortical CMI in patients with stroke can be considered as a cerebral frailty condition which counteracts to the recovery process, suggesting a reduced brain plasticity among these patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.118.024672","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T09:00:30Z","timestamp":1557824430000},"page":"1430-1436","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Chronic Cortical Cerebral Microinfarcts Slow Down Cognitive Recovery After Acute Ischemic Stroke"],"prefix":"10.1161","volume":"50","author":[{"given":"Sharmila","family":"Sagnier","sequence":"first","affiliation":[{"name":"From the UMR 5287 CNRS, Universit\u00e9 de Bordeaux, EPHE PSL Research University, France (S.S., G.C., I.S.)"},{"name":"CHU de Bordeaux, Unit\u00e9 Neuro-vasculaire, France (S.S., S.D., M.P., S.O., P.R., F.R., I.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gosuke","family":"Okubo","sequence":"additional","affiliation":[{"name":"INSERM-U1215, Neurocentre Magendie, Bordeaux, France (G.O., A.B., V.D., T.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwena\u00eblle","family":"Catheline","sequence":"additional","affiliation":[{"name":"From the UMR 5287 CNRS, Universit\u00e9 de Bordeaux, EPHE PSL Research University, France (S.S., G.C., I.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Munsch","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Neuroimagerie diagnostique et th\u00e9rapeutique, France (F.M., V.D., T.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Bigourdan","sequence":"additional","affiliation":[{"name":"INSERM-U1215, Neurocentre Magendie, Bordeaux, France (G.O., A.B., V.D., T.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Debruxelles","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Unit\u00e9 Neuro-vasculaire, France (S.S., S.D., M.P., S.O., P.R., F.R., I.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Poli","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Unit\u00e9 Neuro-vasculaire, France (S.S., S.D., M.P., S.O., P.R., F.R., I.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Olindo","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Unit\u00e9 Neuro-vasculaire, France (S.S., S.D., M.P., S.O., P.R., F.R., I.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Renou","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Unit\u00e9 Neuro-vasculaire, France (S.S., S.D., M.P., S.O., P.R., F.R., I.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Rouanet","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Unit\u00e9 Neuro-vasculaire, France (S.S., S.D., M.P., S.O., P.R., F.R., I.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Dousset","sequence":"additional","affiliation":[{"name":"INSERM-U1215, Neurocentre Magendie, Bordeaux, France (G.O., A.B., V.D., T.T.)"},{"name":"CHU de Bordeaux, Neuroimagerie diagnostique et th\u00e9rapeutique, France (F.M., V.D., T.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Tourdias","sequence":"additional","affiliation":[{"name":"INSERM-U1215, Neurocentre Magendie, Bordeaux, France (G.O., A.B., V.D., T.T.)"},{"name":"CHU de Bordeaux, Neuroimagerie diagnostique et th\u00e9rapeutique, France (F.M., V.D., 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