{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:39:20Z","timestamp":1792157960638,"version":"4.4.0"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>\n                      The ring finger protein 213 gene (\n                      <jats:italic>RNF213<\/jats:italic>\n                      ) is a susceptibility gene for moyamoya disease and large-artery ischemic stroke in East Asia. We examined the prevalence and correlates of the\n                      <jats:italic>RNF213<\/jats:italic>\n                      p.R4810K variant in patients with early-onset ischemic stroke in a Japanese single-center cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>We analyzed 70 early-onset stroke patients with intracranial arterial stenosis who developed a noncardioembolic stroke or transient ischemic attack from 20 to 60 years of age. Patients with moyamoya disease were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>RNF213<\/jats:italic>\n                      p.R4810K variant was found in 17 patients (24%), and more often in women than men (38% versus 16%, odds ratio 3.3; 95% CI, 1.1\u201310.2,\n                      <jats:italic>P<\/jats:italic>\n                      =0.04). The variant was identified in 35% of patients with stenosis in the M1 segment of the middle cerebral artery or the A1 segment of the anterior cerebral artery (odds ratio, 25.0; 95% CI, 1.4\u2013438;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01) but in only one patient (9%) with intracranial posterior circulation stenosis. Conventional atherosclerotic risk factors did not differ between variant carriers and noncarriers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>RNF213<\/jats:italic>\n                      p.R4810K variant is common in early-onset ischemic stroke with anterior circulation stenosis in Japan. Further investigation of the\n                      <jats:italic>RNF213<\/jats:italic>\n                      gene will provide new insights into pathogenetic mechanisms of early-onset stroke.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.118.024712","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T13:37:51Z","timestamp":1557236271000},"page":"1561-1563","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Prevalence of\n                    <i>RNF213<\/i>\n                    p.R4810K Variant in Early-Onset Stroke With Intracranial Arterial Stenosis"],"prefix":"10.1161","volume":"50","author":[{"given":"Teppei","family":"Kamimura","sequence":"first","affiliation":[{"name":"From the Department of Neurology (T.K., S.O., T.Y., M.I.), National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Okazaki","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (T.K., S.O., T.Y., M.I.), National Cerebral and Cardiovascular Center, Osaka, Japan"},{"name":"Department of Neurology, Osaka University Graduate School of Medicine, Japan (S.O.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan (T.K., H.M.)"},{"name":"Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Japan (T.M., H.K., K.H., A.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatasu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Japan (T.M., H.K., K.H., A.K.)"},{"name":"Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Aichi, Japan (H.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Japan (T.M., H.K., K.H., A.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Tomita","sequence":"additional","affiliation":[{"name":"NCVC Biobank (T.T., A.H.), National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Higashiyama","sequence":"additional","affiliation":[{"name":"NCVC Biobank (T.T., A.H.), National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (T.K., S.O., T.Y., M.I.), National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun C.","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery (J.C.T., J.N.), National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoji","family":"Nakagawara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery (J.C.T., J.N.), National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine (M.K., K.T.), National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine (M.K., K.T.), National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan (T.K., H.M.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Japan (T.M., H.K., K.H., A.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Ihara","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (T.K., S.O., T.Y., M.I.), National Cerebral and Cardiovascular Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2010.132"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022542"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12199-015-0498-7"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12199-012-0299-1"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12199-016-0549-8"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038439"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2014.16.1.8"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.52.245"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.663864"},{"key":"e_1_3_4_11_2","first-page":"1","article-title":"A polymorphism RNF213 is a susceptibility gene for intracranial atherosclerosis.","volume":"11","author":"Bang OY","year":"2016","unstructured":"Bang, OY, Chung, JW, Cha, J, Lee, MJ, Yeon, JY, Ki, CS, et al. A polymorphism RNF213 is a susceptibility gene for intracranial atherosclerosis. PLoS One. 2016;11:1\u20139.","journal-title":"PLoS One"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.118.024712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T03:22:41Z","timestamp":1738812161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.118.024712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1161\/STROKEAHA.118.024712"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.118.024712","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735708920.793560217","asserted-by":"object"}]},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"2018-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}