{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:57:41Z","timestamp":1791374261258,"version":"4.3.1"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Although obesity is an established risk factor for cardiovascular disease and stroke, studies have shown evidence of an obesity paradox\u2014a protective effect of obesity in patients who already have these disease states. Data on the obesity paradox in intracerebral hemorrhage is limited.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Clinical data for adult intracerebral hemorrhage patients were extracted from the National Inpatient Sample between 2007 and 2014. Multivariable logistic regression analyzed the association of body habitus with in-hospital mortality, discharge disposition, length of stay, tracheostomy or gastrostomy placement, and ventriculoperitoneal shunt placement.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              There were 99\u2009212 patients who were eligible. Patients with both obesity (OR=0.69; 95% CI=0.62\u20130.76;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and morbid obesity (OR=0.85; 95% CI=0.74\u20130.97;\n              <jats:italic>P<\/jats:italic>\n              =0.02) were associated with decreased odds of in-hospital mortality. Morbid obesity was significantly associated with increased odds of a tracheostomy or gastrostomy placement (OR=1.42; 1.20\u20131.69;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and decreased odds of a routine discharge disposition (OR=0.84; 0.74\u20130.97;\n              <jats:italic>P<\/jats:italic>\n              =0.014).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Obesity and morbid obesity appear to protect against mortality in intracerebral hemorrhage.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.119.024638","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T09:02:17Z","timestamp":1552899737000},"page":"999-1002","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Obesity Paradox in Intracerebral Hemorrhage"],"prefix":"10.1161","volume":"50","author":[{"given":"Steven R.","family":"Persaud","sequence":"first","affiliation":[{"name":"From the Department of Neurosurgery (S.R.P., A.C.L., N.S.D., X.Z., J.M., C.P.K.), Mount Sinai Hospital, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam C.","family":"Lieber","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (S.R.P., A.C.L., N.S.D., X.Z., J.M., C.P.K.), Mount Sinai Hospital, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Donath","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of General Internal Medicine (E.D.), Mount Sinai Hospital, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette A.","family":"Stingone","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Mailman School of Public Health, Columbia University, New York (J.A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha S.","family":"Dangayach","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (S.R.P., A.C.L., N.S.D., X.Z., J.M., C.P.K.), Mount Sinai Hospital, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangnan","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (S.R.P., A.C.L., N.S.D., X.Z., J.M., C.P.K.), Mount Sinai Hospital, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Mocco","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (S.R.P., A.C.L., N.S.D., X.Z., J.M., C.P.K.), Mount Sinai Hospital, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Kellner","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (S.R.P., A.C.L., N.S.D., X.Z., J.M., C.P.K.), Mount Sinai Hospital, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105103441907"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1394-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"663, ix","DOI":"10.1016\/j.ecl.2008.06.004","article-title":"Impact of obesity on cardiovascular disease.","volume":"37","author":"Zalesin KC","year":"2008","unstructured":"Zalesin, KC, Franklin, BA, Miller, WM, Peterson, ED, McCullough, PA. Impact of obesity on cardiovascular disease. Endocrinol Metab Clin North Am. 2008;37:663, ix\u2013684, ix.","journal-title":"Endocrinol Metab Clin North Am"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2017.45"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13137"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69251-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3171\/2016.4.JNS152562"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000735"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6447a1"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.06.036"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493016670175"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000025"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31820b7667"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.09.029"}],"updated-by":[{"DOI":"10.1161\/str.0000000000000192","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000}}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.119.024638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:33:03Z","timestamp":1715614383000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.119.024638"}},"subtitle":["National Inpatient Sample Analysis"],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1161\/STROKEAHA.119.024638"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.119.024638","relation":{"correction":[{"id-type":"doi","id":"10.1161\/STR.0000000000000192","asserted-by":"object"}]},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"2018-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}