{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:24:53Z","timestamp":1791584693172,"version":"4.3.4"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>Intracranial atherosclerosis (ICAS) is an important cause of large vessel occlusion and poses unique challenges for emergent endovascular thrombectomy. The risk factor profile and therapeutic outcomes of patients with ICAS-related occlusions (ICAS-O) are unclear. We performed a systematic review and meta-analysis of studies reporting the clinical features and thrombectomy outcomes of large vessel occlusion stroke secondary to underlying ICAS (ICAS-O) versus those of other causes (non\u2013ICAS-O).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>A literature search on thrombectomy for ICAS-O was performed. Random-effect meta-analysis was used to analyze the prevalence of stroke risk factors and outcomes of thrombectomy between ICAS-O and non\u2013ICAS-O groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>A total of 1967 patients (496 ICAS-O and 1471 non\u2013ICAS-O) were included. The ICAS-O group had significantly higher prevalence of hypertension (odds ratio [OR] 1.46; 95% CI, 1.10\u20131.93), diabetes mellitus (OR, 1.68; 95% CI, 1.29\u20132.20), dyslipidemia (OR, 1.94; 95% CI, 1.04\u20133.62), smoking history (OR, 2.11; 95% CI, 1.40\u20133.17) but less atrial fibrillation (OR, 0.20; 95% CI, 0.13\u20130.31) than the non\u2013ICAS-O group. About thrombectomy outcomes, ICAS-O had higher intraprocedural reocclusion rate (OR, 23.7; 95% CI, 6.96\u201380.7), need for rescue balloon angioplasty (OR, 9.49; 95% CI, 4.11\u201321.9), rescue intracranial stenting (OR, 14.9; 95% CI, 7.64\u201329.2), and longer puncture-to-reperfusion time (80.8 versus 55.5 minutes, mean difference 21.3; 95% CI, 11.3\u201331.3). There was no statistical difference in the rate of final recanalization (modified Thrombolysis in Cerebral Infarction score of 2b\/3; OR, 0.67; 95% CI, 0.36\u20131.27), symptomatic intracerebral hemorrhage (OR, 0.79; 95% CI, 0.50\u20131.24), good functional outcome (modified Rankin Scale score of 0\u20132; OR, 1.16; 95% CI, 0.85\u20131.58), and mortality (OR, 0.94; 95% CI, 0.64\u20131.39) between ICAS-O and non\u2013ICAS-O.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Patients with ICAS-O display a unique risk factor profile and technical challenges for endovascular reperfusion therapy. Intraprocedural reocclusion occurs in one-third of patients with ICAS-O. Intraarterial glycoprotein IIb\/IIIa inhibitors infusion, balloon angioplasty, and intracranial stenting may be viable rescue treatment to achieve revascularization, resulting in comparable outcomes to non\u2013ICAS-O.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.119.024889","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T05:00:30Z","timestamp":1557810030000},"page":"1460-1466","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":195,"title":["Thrombectomy Outcomes of Intracranial Atherosclerosis-Related Occlusions"],"prefix":"10.1161","volume":"50","author":[{"given":"Anderson Chun On","family":"Tsang","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery (A.C.O.T., F.C.P.T., W.M.L.), The University of Hong Kong"},{"name":"Division of Neuroradiology, Joint Department of Medical Imaging (A.C.O.T., E.O., J.M.K., I.-H.Y., V.M.P., T.K.), Toronto Western Hospital, University of Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Orru","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Joint Department of Medical Imaging (A.C.O.T., E.O., J.M.K., I.-H.Y., V.M.P., T.K.), Toronto Western Hospital, University of Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse M.","family":"Klostranec","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Joint Department of Medical Imaging (A.C.O.T., E.O., J.M.K., I.-H.Y., V.M.P., T.K.), Toronto Western Hospital, University of Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Hsiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Joint Department of Medical Imaging (A.C.O.T., E.O., J.M.K., I.-H.Y., V.M.P., T.K.), Toronto Western Hospital, University of Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui Kai","family":"Lau","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine (K.K.L.), The University of Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick Chun Pong","family":"Tsang","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery (A.C.O.T., F.C.P.T., W.M.L.), The University of Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Man","family":"Lui","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery (A.C.O.T., F.C.P.T., W.M.L.), The University of Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Mendes","family":"Pereira","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Joint Department of Medical Imaging (A.C.O.T., E.O., J.M.K., I.-H.Y., V.M.P., T.K.), Toronto Western Hospital, University of Toronto, Canada."},{"name":"Division of Neurosurgery, Department of Surgery, University Health Network (V.M.P.), Toronto Western Hospital, University of Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Krings","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Joint Department of Medical Imaging (A.C.O.T., E.O., J.M.K., I.-H.Y., V.M.P., T.K.), Toronto Western Hospital, University of Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000158"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5825"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2015.01347"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2017.00626"},{"key":"e_1_3_3_6_2","unstructured":"Wells GA Shea B O\u2019Connell D Peterson J Welch V Losos M et al. 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