{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:58:04Z","timestamp":1790384284071,"version":"4.1.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>In this study, we aim to investigate the association of computed tomography\u2013based markers of cerebral small vessel disease with functional outcome and recovery after intracerebral hemorrhage.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Computed tomographic scans of patients in the ERICH study (Ethnic and Racial Variations of Intracerebral Hemorrhage) were evaluated for the extent of leukoaraiosis and cerebral atrophy using visual rating scales. Poor functional outcome was defined as a modified Rankin Scale (mRS) of \u22653. Multivariable logistic and linear regression models were used to explore the associations of cerebral small vessel disease imaging markers with poor functional outcome at discharge and, as a measure of recovery, change in mRS from discharge to 90 days poststroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              After excluding in-hospital deaths, data from 2344 patients, 583 (24.9%) with good functional outcome (mRS of 0\u20132) at discharge and 1761 (75.1%) with poor functional outcome (mRS of 3\u20135) at discharge, were included. Increasing extent of leukoaraiosis (\n              <jats:italic>P<\/jats:italic>\n              for trend, 0.01) and only severe (grade 4) global atrophy (odds ratio, 2.02; 95% CI, 1.22\u20133.39,\n              <jats:italic>P<\/jats:italic>\n              =0.007) were independently associated with poor functional outcome at discharge. Mean (SD) mRS change from discharge to 90-day follow-up was 0.57 (1.18). Increasing extent of leukoaraiosis (\n              <jats:italic>P<\/jats:italic>\n              for trend, 0.002) and severe global atrophy (\u03b2 [SE], \u22120.23 [0.115];\n              <jats:italic>P<\/jats:italic>\n              =0.045) were independently associated with less improvement in mRS from discharge to 90 days poststroke.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In intracerebral hemorrhage survivors, the extent of cerebral small vessel disease at the time of intracerebral hemorrhage is associated with poor functional outcome at hospital discharge and impaired functional recovery from discharge to 90 days poststroke.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.119.025061","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T09:00:22Z","timestamp":1566810022000},"page":"2722-2728","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Impact of Cerebral Small Vessel Disease on Functional Recovery After Intracerebral Hemorrhage"],"prefix":"10.1161","volume":"50","author":[{"given":"Simone M.","family":"Uniken Venema","sequence":"first","affiliation":[{"name":"From the Center for Genomic Medicine (S.M.U.V., S.M., U.K.L., C.K., C.D.A., J.R.), Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Marini","sequence":"additional","affiliation":[{"name":"From the Center for Genomic Medicine (S.M.U.V., S.M., U.K.L., C.K., C.D.A., J.R.), Massachusetts General Hospital, Boston"},{"name":"Division of Neurocritical Care and Emergency Neurology, Department of Neurology (S.M., C.D.A., J.R.)"},{"name":"J.P. Kistler Stroke Research Center (S.M., M.J., C.D.A., J.R.), Massachusetts General Hospital, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umme K.","family":"Lena","sequence":"additional","affiliation":[{"name":"From the Center for Genomic Medicine (S.M.U.V., S.M., U.K.L., C.K., C.D.A., J.R.), Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Morotti","sequence":"additional","affiliation":[{"name":"Stroke Unit, Instituto Neurologico Nazionale a Carattere Scientifico (IRCCS) Mondino Foundation, Pavia, Italy (A.M.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Jessel","sequence":"additional","affiliation":[{"name":"J.P. Kistler Stroke Research Center (S.M., M.J., C.D.A., J.R.), Massachusetts General Hospital, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J.","family":"Moomaw","sequence":"additional","affiliation":[{"name":"Department Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, OH (C.J.M., D.W.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Kourkoulis","sequence":"additional","affiliation":[{"name":"From the Center for Genomic Medicine (S.M.U.V., S.M., U.K.L., C.K., C.D.A., J.R.), Massachusetts General Hospital, Boston"},{"name":"Henry and Allison McCance Center for Brain Health (C.K., C.D.A., J.R.), Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando D.","family":"Testai","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation, University of Illinois College of Medicine, Chicago (F.D.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Kittner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Baltimore Veterans Administration Medical Center, University of Maryland School of Medicine (S.J.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Bart","family":"Brouwers","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands (H.B.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"James","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology (M.L.J.), Brain Injury Translational Research Center, Duke University, Durham, NC."},{"name":"Neurology (M.L.J.), Brain Injury Translational Research Center, Duke University, Durham, NC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Woo","sequence":"additional","affiliation":[{"name":"Department Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, OH (C.J.M., D.W.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Henry and Allison McCance Center for Brain Health (C.K., C.D.A., J.R.), Massachusetts General Hospital, Boston"},{"name":"Division of Neurocritical Care and Emergency Neurology, Department of Neurology (S.M., C.D.A., J.R.)"},{"name":"J.P. 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