{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:27:05Z","timestamp":1793262425099,"version":"4.5.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>\n              Plaque inflammation contributes to stroke and coronary events.\n              <jats:sup>18<\/jats:sup>\n              F-fluorodeoxyglucose (FDG) positron emission tomography (PET) identifies plaque inflammation-related metabolism. Almost no prospective data exist on the relationship of carotid\n              <jats:sup>18<\/jats:sup>\n              F-FDG uptake and early recurrent stroke.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>\n              We did a multicenter prospective cohort study BIOVASC (Biomarkers\/Imaging Vulnerable Atherosclerosis in Symptomatic Carotid disease) of patients with carotid stenosis and recent stroke\/transient ischemic attack with 90-day follow-up. On coregistered carotid\n              <jats:sup>18<\/jats:sup>\n              F-FDG PET\/computed tomography angiography,\n              <jats:sup>18<\/jats:sup>\n              F-FDG uptake was expressed as maximum standardized uptake value (SUV\n              <jats:sub>max<\/jats:sub>\n              ) in the axial single hottest slice. We then conducted a systematic review of similar studies and pooled unpublished individual-patient data with 2 highly similar independent studies (Dublin and Barcelona). We analyzed the association of SUV\n              <jats:sub>max<\/jats:sub>\n              with all recurrent nonprocedural stroke (before and after PET) and with recurrent stroke after PET only.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              In BIOVASC (n=109, 14 recurrent strokes), after adjustment (for age, sex, stenosis severity, antiplatelets, statins, diabetes mellitus, hypertension, and smoking), the hazard ratio for recurrent stroke per 1 g\/mL SUV\n              <jats:sub>max<\/jats:sub>\n              was 2.2 (CI, 1.1\u20134.5;\n              <jats:italic>P<\/jats:italic>\n              =0.025). Findings were consistent in the independent Dublin (n=52, hazard ratio, 2.2; CI, 1.1\u20134.3) and Barcelona studies (n=35, hazard ratio, 2.8; CI, 0.98\u20135.5). In the pooled cohort (n=196), 37 recurrent strokes occurred (29 before and 8 after PET). Plaque SUV\n              <jats:sub>max<\/jats:sub>\n              was higher in patients with all recurrence (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) and post-PET recurrence (\n              <jats:italic>P<\/jats:italic>\n              =0.009). The fully adjusted hazard ratio of any recurrent stroke was 2.19 (CI, 1.41\u20133.39;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and for post-PET recurrent stroke was 4.57 (CI, 1.5\u201313.96;\n              <jats:italic>P<\/jats:italic>\n              =0.008). Recurrent stroke risk increased across SUV\n              <jats:sub>max<\/jats:sub>\n              quartiles (log-rank\n              <jats:italic>P<\/jats:italic>\n              =0.003). The area under receiver operating curve for all recurrence was 0.70 (CI, 0.59\u20130.78) and for post-PET recurrence was 0.80 (CI, 0.64\u20130.96).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              Plaque inflammation-related\n              <jats:sup>18<\/jats:sup>\n              F-FDG uptake independently predicted future recurrent stroke post-PET. Although further studies are needed,\n              <jats:sup>18<\/jats:sup>\n              F-FDG PET may improve patient selection for carotid revascularization and suggest that anti-inflammatory agents may have benefit for poststroke vascular prevention.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.119.025422","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T09:00:24Z","timestamp":1559811624000},"page":"1766-1773","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":99,"title":["Carotid Plaque Inflammation Imaged by\n            <sup>18<\/sup>\n            F-Fluorodeoxyglucose Positron Emission Tomography and Risk of Early Recurrent Stroke"],"prefix":"10.1161","volume":"50","author":[{"given":"Peter J.","family":"Kelly","sequence":"first","affiliation":[{"name":"From the Neurovascular Clinical Science Unit, Stroke Service and Department of Neurology (P.J.K., N.G., S.M., G.H., M.M.), University College Dublin, Ireland"},{"name":"HRB Stroke Clinical Trials Network Ireland (P.J.K., S.M., S.C., E.D., J.H., G.H., M.M., D.W.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pol","family":"Camps-Renom","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Aut\u00f2noma de Barcelona (Department of Medicine), Barcelona, Spain (P.C.-R., J.M.-F., R.D.-M.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Giannotti","sequence":"additional","affiliation":[{"name":"From the Neurovascular Clinical Science Unit, Stroke Service and Department of Neurology (P.J.K., N.G., S.M., G.H., M.M.), University College Dublin, Ireland"},{"name":"Mater University Hospital, Radiography and Diagnostic Imaging, School of Medicine (N.G., J.M., S.F.), University College Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Mart\u00ed-F\u00e0bregas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Aut\u00f2noma de Barcelona (Department of Medicine), Barcelona, Spain (P.C.-R., J.M.-F., R.D.-M.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Murphy","sequence":"additional","affiliation":[{"name":"From the Neurovascular Clinical Science Unit, Stroke Service and Department of Neurology (P.J.K., N.G., S.M., G.H., M.M.), University College Dublin, Ireland"},{"name":"HRB Stroke Clinical Trials Network Ireland (P.J.K., S.M., S.C., E.D., J.H., G.H., M.M., D.W.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"McNulty","sequence":"additional","affiliation":[{"name":"Mater University Hospital, Radiography and Diagnostic Imaging, School of Medicine (N.G., J.M., S.F.), University College Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Barry","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, St Vincent\u2019s University Hospital (M.B.), University College Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Barry","sequence":"additional","affiliation":[{"name":"Stroke Service, Departments of Geriatric Medicine, Cork University Hospital, Ireland (P.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Calvet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, INSERM UMR S 894, Service de Neurologie et Unit\u00e9 Neurovasculaire, H\u00f4pital Sainte-Anne, Paris, France (D.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelagh B.","family":"Coutts","sequence":"additional","affiliation":[{"name":"Departments of Clinical Neurosciences, Radiology and Community Health Sciences, Hotchkiss Brain Institute, University of Calgary, AB, Canada (S.B.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Cronin","sequence":"additional","affiliation":[{"name":"HRB Stroke Clinical Trials Network Ireland (P.J.K., S.M., S.C., E.D., J.H., G.H., M.M., D.W.)"},{"name":"Department of Neurology, Cork University Hospital, and Department of Clinical Neuroscience, College of Medicine and Health, University College Cork, Ireland (S.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Delgado-Mederos","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Universitat Aut\u00f2noma de Barcelona (Department of Medicine), Barcelona, Spain (P.C.-R., J.M.-F., R.D.-M.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eamon","family":"Dolan","sequence":"additional","affiliation":[{"name":"HRB Stroke Clinical Trials Network Ireland (P.J.K., S.M., S.C., E.D., J.H., G.H., M.M., D.W.)"},{"name":"Connolly Hospital Dublin and Royal College of Surgeons Ireland (E.D.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Fern\u00e1ndez-Le\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (A.F.-L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Foley","sequence":"additional","affiliation":[{"name":"Mater University Hospital, Radiography and Diagnostic Imaging, School of Medicine (N.G., J.M., S.F.), University College Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Harbison","sequence":"additional","affiliation":[{"name":"HRB Stroke Clinical Trials Network Ireland (P.J.K., S.M., S.C., E.D., J.H., G.H., M.M., D.W.)"},{"name":"Stroke Service, Department of Geriatric Medicine, St James\u2019 Hospital and Trinity College Dublin, Ireland (J.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Horgan","sequence":"additional","affiliation":[{"name":"From the Neurovascular Clinical Science Unit, Stroke Service and Department of Neurology (P.J.K., N.G., S.M., G.H., M.M.), University College Dublin, Ireland"},{"name":"HRB Stroke Clinical Trials Network Ireland (P.J.K., S.M., S.C., E.D., J.H., G.H., M.M., D.W.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoin","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"Department of Radiology (E.K., M. O\u2019Connell), University College Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Marnane","sequence":"additional","affiliation":[{"name":"From the Neurovascular Clinical Science Unit, Stroke Service and Department of Neurology (P.J.K., N.G., S.M., G.H., M.M.), University College Dublin, Ireland"},{"name":"HRB Stroke Clinical Trials Network Ireland (P.J.K., S.M., S.C., E.D., J.H., G.H., M.M., D.W.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciaran","family":"McDonnell","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery (C.M., M. O\u2019Donohoe), University College Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"O\u2019Donohoe","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery (C.M., M. 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Colchicine for prevention of Vascular Inflammation in Non-CardioEmbolic stroke (CONVINCE). EudraCT:2015-004505-16. https:\/\/www.clinicaltrialsregister.eu\/ctr-search\/search?query=2015-004505-16. Accessed 4.5.2019."}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.119.025422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:30:58Z","timestamp":1715614258000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.119.025422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1161\/STROKEAHA.119.025422"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.119.025422","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"2019-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}