{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:22:27Z","timestamp":1792549347299,"version":"4.5.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Transient global amnesia (TGA) is known as a benign syndrome, but recent data from neuroradiological studies support an ischemic cause in some cases, which might suggest an increased susceptibility to cerebrovascular events. We determined the long-term risk of stroke after a first TGA in 2 independent prospective cohorts.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>In 2 independent prospective cohorts of patients with TGA (OXVASC [Oxford Vascular Study], population-based; NU (Northern Umbria) cohort, TGA registry), cardiovascular risk factors and long-term outcomes, including stroke and major cardiovascular events, were identified on follow-up. Cardiovascular risk factors were treated according to primary prevention guidelines. In OXVASC, the age-\/sex-adjusted risk of stroke during follow-up was compared with that expected from the rate in the underlying study population.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Among 525 patients with TGA (425 NU and 100 OXVASC), mean (SD) age was 65.1 (9.5) years and 42.5% male. Hypertension (58.1%), dyslipidemia (40.4%), and smoking (36.4%) were the most frequent cardiovascular risk factors. The risk of stroke was similar in the 2 cohorts, with a pooled annual risk of 0.6% (95% CI, 0.4\u20130.9) and a 5-year cumulative risk of 2.7% (1.1\u20134.3). Moreover, the stroke risk in OXVASC cases was no greater than that expected in the underlying study population (adjusted relative risk=0.73; 0.12\u20134.54;\n              <jats:italic>P<\/jats:italic>\n              =0.74).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>TGA does not carry an increased risk of stroke, at least when cardiovascular risk factors are treated according to primary prevention guidelines.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.119.025720","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T09:00:23Z","timestamp":1562662823000},"page":"2555-2557","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Long-Term Risk of Stroke After Transient Global Amnesia in Two Prospective Cohorts"],"prefix":"10.1161","volume":"50","author":[{"given":"Michele","family":"Romoli","sequence":"first","affiliation":[{"name":"From the Centre for the Prevention of Stroke and Dementia, Nuffield Department of Clinical Neuroscience, University of Oxford, United Kingdom (M.R., M.A.T., I.M., L.L., P.M.R.)"},{"name":"Neurology Clinic (M.R., P.E., F.T.C., A.L., N.S., P.S., L.P., P.C.), University of Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Assuncao","family":"Tuna","sequence":"additional","affiliation":[{"name":"From the Centre for the Prevention of Stroke and Dementia, Nuffield Department of Clinical Neuroscience, University of Oxford, United Kingdom (M.R., M.A.T., I.M., L.L., P.M.R.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"McGurgan","sequence":"additional","affiliation":[{"name":"From the Centre for the Prevention of Stroke and Dementia, Nuffield Department of Clinical Neuroscience, University of Oxford, United Kingdom (M.R., M.A.T., I.M., L.L., P.M.R.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxin","family":"Li","sequence":"additional","affiliation":[{"name":"From the Centre for the Prevention of Stroke and Dementia, Nuffield Department of Clinical Neuroscience, University of Oxford, United Kingdom (M.R., M.A.T., I.M., L.L., P.M.R.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Giannandrea","sequence":"additional","affiliation":[{"name":"Neurology and Stroke Unit, USL Umbria 1, Gubbio and Citt\u00e0 di Castello Hospital, Perugia, Italy (D.G., S.R.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Eusebi","sequence":"additional","affiliation":[{"name":"Neurology Clinic (M.R., P.E., F.T.C., A.L., N.S., P.S., L.P., P.C.), University of Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Tordo Caprioli","sequence":"additional","affiliation":[{"name":"Neurology Clinic (M.R., P.E., F.T.C., A.L., N.S., P.S., L.P., P.C.), University of Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Lotti","sequence":"additional","affiliation":[{"name":"Neurology Clinic (M.R., P.E., F.T.C., A.L., N.S., P.S., L.P., P.C.), University of Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Salvadori","sequence":"additional","affiliation":[{"name":"Neurology Clinic (M.R., P.E., F.T.C., A.L., N.S., P.S., L.P., P.C.), University of Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Sarchielli","sequence":"additional","affiliation":[{"name":"Neurology Clinic (M.R., P.E., F.T.C., A.L., N.S., P.S., L.P., P.C.), University of Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Gili","sequence":"additional","affiliation":[{"name":"S. Maria della Misericordia Hospital, and Public Health Department (A.G., F.S.), University of Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giulia","family":"Mosconi","sequence":"additional","affiliation":[{"name":"Stroke Unit (M.G.M., M.P.V., M.P.), University of Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Pellizzaro Venti","sequence":"additional","affiliation":[{"name":"Stroke Unit (M.G.M., M.P.V., M.P.), University of Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Stracci","sequence":"additional","affiliation":[{"name":"S. Maria della Misericordia Hospital, and Public Health Department (A.G., F.S.), University of Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Ricci","sequence":"additional","affiliation":[{"name":"Neurology and Stroke Unit, USL Umbria 1, Gubbio and Citt\u00e0 di Castello Hospital, Perugia, Italy (D.G., S.R.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Paciaroni","sequence":"additional","affiliation":[{"name":"Stroke Unit (M.G.M., M.P.V., M.P.), University of Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucilla","family":"Parnetti","sequence":"additional","affiliation":[{"name":"Neurology Clinic (M.R., P.E., F.T.C., A.L., N.S., P.S., L.P., P.C.), University of Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Calabresi","sequence":"additional","affiliation":[{"name":"Neurology Clinic (M.R., P.E., F.T.C., A.L., N.S., P.S., L.P., P.C.), University of Perugia, Italy"},{"name":"IRCCS, Santa Lucia, Rome, Italy (P.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Malcolm","family":"Rothwell","sequence":"additional","affiliation":[{"name":"From the Centre for the Prevention of Stroke and Dementia, Nuffield Department of Clinical Neuroscience, University of Oxford, United Kingdom (M.R., M.A.T., I.M., L.L., P.M.R.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.53.10.834"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1051228404272878"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.042432"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2004.00275.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.9.1536"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410180610"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2004.00982.x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003916"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.11.015"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1980.tb01473.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410070313"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.37.5.733"},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1001\/jama.1979.03290300034024","article-title":"Long-term prognosis in transient global amnesia.","volume":"241","author":"Nausieda PA","year":"2003","unstructured":"Nausieda, PA. Long-term prognosis in transient global amnesia. JAMA J Am Med Assoc. 2003;241:392\u2013393.","journal-title":"JAMA J Am Med Assoc"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/113.3.639"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67702-1"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.119.025720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:12:34Z","timestamp":1715613154000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.119.025720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1161\/STROKEAHA.119.025720"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.119.025720","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"2019-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}