{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:30:26Z","timestamp":1791487826842,"version":"4.3.4"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Deafferentation of the cortico-ponto-cerebellar pathway has been proposed as a key mechanism of crossed cerebellar diaschisis. Although the cerebellum receives afferent stimuli from both cortico-ponto-cerebellar and spinocerebellar pathways, evidence on whether spinocerebellar deafferentation contributes to a hypofunctional cerebellum is lacking. Therefore, we aimed to determine whether changes in the spinocerebellar pathway occur after middle cerebral artery stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>\n              Twenty-three patients admitted to our inpatient rehabilitation facility and 23 age-matched healthy controls were retrospectively enrolled. Patients\u2019 functional ambulation category was determined and the Medical Research Council muscle scale test of the lower limb muscles was performed at admission and discharge. The fractional anisotropy (FA) values of the corticospinal tract and the inferior cerebellar peduncle (ICP), as the final route of the dorsal spinocerebellar pathway, were compared between the groups. The FA laterality indices of the ICP and corticospinal tract were calculated as follows: (FA\n              <jats:sub>affected<\/jats:sub>\n              \u2212FA\n              <jats:sub>unaffected<\/jats:sub>\n              )\/(FA\n              <jats:sub>affected<\/jats:sub>\n              +FA\n              <jats:sub>unaffected<\/jats:sub>\n              ). Pearson correlation analysis and multivariate linear regression models were used to determine the associations between the FA laterality indices and ambulatory function.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>The FAs of the corticospinal tract and ICP were lower in the patient group than in the control group. The FA laterality index of the corticospinal tract was not correlated with the functional ambulation category or Medical Research Council muscle scale score at admission or discharge. The FA laterality index of the ICP at the pontomedullary junction was positively correlated with the functional ambulation category and Medical Research Council muscle scale scores of all hemiplegic lower limb muscles at admission and discharge. The FA laterality index of the ICP at the pontomedullary junction was independently associated with the functional ambulation category according to the multivariate regression models.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>ICP degeneration occurs in the subacute and early chronic phase of middle cerebral artery stroke. The lower FA laterality index of the ICP was indicative of poorer ambulatory and lower limb function.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.119.025723","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T09:00:22Z","timestamp":1566810022000},"page":"2700-2707","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Degeneration of the Inferior Cerebellar Peduncle After Middle Cerebral Artery Stroke"],"prefix":"10.1161","volume":"50","author":[{"given":"Joon Sung","family":"Kim","sequence":"first","affiliation":[{"name":"From the Department of Rehabilitation Medicine (J.S.K., S.H.L., B.Y.H.), St Vincent\u2019s Hospital, College of Medicine, The Catholic University of Korea, Suwon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se-Hong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Family Medicine (S.-H.K.), St Vincent\u2019s Hospital, College of Medicine, The Catholic University of Korea, Suwon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hoon","family":"Lim","sequence":"additional","affiliation":[{"name":"From the Department of Rehabilitation Medicine (J.S.K., S.H.L., B.Y.H.), St Vincent\u2019s Hospital, College of Medicine, The Catholic University of Korea, Suwon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Bucheon St Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea (S.I.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Young","family":"Hong","sequence":"additional","affiliation":[{"name":"From the Department of Rehabilitation Medicine (J.S.K., S.H.L., B.Y.H.), St Vincent\u2019s Hospital, College of Medicine, The Catholic University of Korea, Suwon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeehae","family":"Oh","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine, Independent Scholar, Seoul, Republic of Korea (J.O.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngkook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Yeouido St Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul (Y.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/109.4.677"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15617953"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02988504"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600162"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600467"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2019.01.026"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.04.039"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24378"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-011-0247-4"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1971.34.6.1035"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90064-1"},{"key":"e_1_3_2_13_2","volume-title":"Functional neuroanatomy: Text and atlas","author":"Afifi AK","year":"2005","unstructured":"Afifi, AK, Bergman, RA. Functional neuroanatomy: Text and atlas. 2nd ed. New York, NY: McGraw Hill Professional; 2005.","edition":"2"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.088229"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/08990220.2013.813843"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/64.1.35"},{"key":"e_1_3_2_17_2","volume-title":"Aids to examination of the peripheral nervous system. Memorandum no. 45","author":"Medical research council","year":"1976","unstructured":"Medical research council. Aids to examination of the peripheral nervous system. Memorandum no. 45. 1976."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.012088"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00160"},{"key":"e_1_3_2_20_2","first-page":"14","article-title":"Crossed-cerebellar diaschisis in cerebral infarction: technetium-99m-HMPAO SPECT and MRI.","volume":"38","author":"Kim SE","year":"1997","unstructured":"Kim, SE, Choi, CW, Yoon, BW, Chung, JK, Roh, JH, Lee, MC, et al. Crossed-cerebellar diaschisis in cerebral infarction: technetium-99m-HMPAO SPECT and MRI. J Nucl Med. 1997;38:14\u201319.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25375"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27553-4"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.3639"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12705"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000152040.27264.1A"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-017-0906-1"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30283-1"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000382"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000269"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2012.04.026"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23059"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-007-1237-0"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.016478"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02381.x"},{"key":"e_1_3_2_35_2","first-page":"660","volume-title":"Neuroanatomy Through Clinical Cases","author":"Blumenfeld H","year":"2002","unstructured":"Blumenfeld, H. Cerebellum. Neuroanatomy Through Clinical Cases. Sunderland, MA: Sinauer Associates Inc;2002:660\u2013664."},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2018.00229"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.119.025723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:30:24Z","timestamp":1715614224000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.119.025723"}},"subtitle":["Another Perspective on Crossed Cerebellar Diaschisis"],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1161\/STROKEAHA.119.025723"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.119.025723","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"2019-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}