{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T20:13:37Z","timestamp":1777234417863,"version":"3.51.4"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Few community-based studies have reported the prevalence of intracranial artery stenosis (ICAS) assessed with magnetic resonance angiography. The aim was to determine the prevalence of ICAS using magnetic resonance angiography in a general population of Japanese men and to investigate the associations between ICAS and conventional cardiovascular risk factors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>The Shiga Epidemiological Study of Subclinical Atherosclerosis randomly recruited and examined participants from Kusatsu City, Shiga, Japan, in 2006 to 2008 (baseline); 740 men returned for follow-up and underwent 1.5 T brain magnetic resonance angiography in 2012 to 2015. Participants were categorized as having no-ICAS, mild-ICAS (1 to &lt;50%), or severe-ICAS (\u226550%) in any of the arteries examined. After excluding the men with a history of stroke, 709 men were analyzed using multivariable logistic regression to assess independent associations of conventional cardiovascular risk factors with reference to the no-ICAS group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>The participants\u2019 mean age was 68.0 years. The age-standardized prevalences of mild and severe-ICAS were 20.7% and 4.5%, respectively (with the population of the 2010 Japanese vital statistics as the reference). Age, hypertension, diabetes mellitus, and dyslipidemia were associated with a higher prevalence of severe-ICAS after simultaneous adjustment for conventional cardiovascular risk factors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In a community-based sample of Japanese men, ICAS was estimated to be present in 25.2%, and related to metabolic risk factors, in addition to hypertension and age. These results support the importance of comprehensive management of conventional cardiovascular risk factors for stroke prevention.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.119.025964","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T09:00:22Z","timestamp":1563786022000},"page":"2967-2969","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Intracranial Artery Stenosis and Its Association With Conventional Risk Factors in a General Population of Japanese Men"],"prefix":"10.1161","volume":"50","author":[{"given":"Satoshi","family":"Shitara","sequence":"first","affiliation":[{"name":"From the Department of Neurosurgery (S. Shitara, K.N.), Shiga University of Medical Science, Otsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Fujiyoshi","sequence":"additional","affiliation":[{"name":"Department of Public Health (A.F., S.T., S. Suzuki, T.I., K.M., H.U.), Shiga University of Medical Science, Otsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hisamatsu","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine and Public Health, Faculty of Medicine, Shimane University, Izumo, Japan (T.H.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayuki","family":"Torii","sequence":"additional","affiliation":[{"name":"Department of Public Health (A.F., S.T., S. Suzuki, T.I., K.M., H.U.), Shiga University of Medical Science, Otsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sentarou","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Public Health (A.F., S.T., S. Suzuki, T.I., K.M., H.U.), Shiga University of Medical Science, Otsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Public Health (A.F., S.T., S. Suzuki, T.I., K.M., H.U.), Shiga University of Medical Science, Otsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisatomi","family":"Arima","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Japan (H.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Shiino","sequence":"additional","affiliation":[{"name":"Molecular Neuroscience Research Center (A.S.), Shiga University of Medical Science, Otsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Nozaki","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (S. Shitara, K.N.), Shiga University of Medical Science, Otsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyuki","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Public Health (A.F., S.T., S. Suzuki, T.I., K.M., H.U.), Shiga University of Medical Science, Otsu, Japan"},{"name":"Center for Epidemiologic Research in Asia (K.M., H.U.), Shiga University of Medical Science, Otsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotsugu","family":"Ueshima","sequence":"additional","affiliation":[{"name":"Department of Public Health (A.F., S.T., S. Suzuki, T.I., K.M., H.U.), Shiga University of Medical Science, Otsu, Japan"},{"name":"Center for Epidemiologic Research in Asia (K.M., H.U.), Shiga University of Medical Science, Otsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the SESSA Research group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00039"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.790048"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmedr.2016.06.013"},{"key":"e_1_3_3_5_2","unstructured":"Statistics Bureau Ministry of Internal Affairs and Communications Japan. Population Census 2010. Available at: http:\/\/www.stat.go.jp\/english\/data\/kokusei\/index.htm. Accessed July 28 2018."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-1292"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000264426.63544.ee"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002491"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011292"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61778-4"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.001974"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.529537"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-0847"}],"updated-by":[{"DOI":"10.1161\/str.0000000000000210","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T00:00:00Z","timestamp":1572220800000}}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.119.025964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:29:47Z","timestamp":1715614187000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.119.025964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1161\/STROKEAHA.119.025964"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.119.025964","relation":{"correction":[{"id-type":"doi","id":"10.1161\/STR.0000000000000210","asserted-by":"object"}]},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"2019-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}