{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:22Z","timestamp":1787018122958,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>The goal of this study was to systematically review the outcomes and complications after surgical resection of brain stem cavernous malformations (BCMs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>A systematic literature review was performed using the PubMed database for studies published between 1986 and 2018. All studies comprising \u22652 patients with surgically resected BCMs and available follow-up data were included. Data extracted from studies included patient demographics, BCM location, and surgical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>Eighty-six studies comprising 2493 patients (adult and pediatric) were included for final analysis. Complete resection was achieved in 92.3% (fixed-effects pooled estimate [FE], 92.9% [91.7%\u201394.0%]; random-effects pooled estimate [RE], 89.4% [86.5%\u201392.0%]) of patients, and rehemorrhage of residual BCMs occurred in 58.6% (FE, 58.8% [49.7%\u201367.6%]; RE, 57.2% [43.5%\u201370.2%]). Postoperative morbidity occurred in 34.8% (FE, 30.9% [29.0%\u201332.8%]; RE, 31.1% [25.8%\u201336.6%]) of patients. Postoperative morbidities included motor deficit in 11.0% (FE, 9.9% [8.1%\u201311.7%]; RE, 11.1% [7.0%\u201316.0%]), sensory deficit in 6.7% (FE, 6.3% [4.8%\u20137.9%]; RE, 7.6% [4.5%\u201311.5%]), tracheostomy\/gastrostomy in 6.0% (FE, 5.2% [4.3%\u20136.1%]; RE, 3.8% [2.6%\u20135.3%]), and other cranial nerve deficits in 29.4% (FE, 27.6% [25.3%\u201329.9%]; RE, 33.9% [25.7%\u201342.6%]) of patients. At final follow-up, 57.9% (FE, 57.6% [55.6%\u201359.6%]; RE, 57.2% [52.1%\u201362.3%]) and 25.9% (FE, 24.1% [22.4%\u201325.9%]; RE, 18.5% [14.6%\u201322.8%]) of patients had improvement and stability of preoperative symptoms, respectively. Mortality rate was 1.6% (FE, 1.9% [1.4%\u20132.5%]; RE, 1.8% [1.4%\u20132.5%]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>High cure rates and low rates of postoperative morbidity can be achieved with surgery in patients with BCMs. Most patients had improved preoperative symptoms at final follow-up. To avoid rehemorrhage, complete resection should be the goal of surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.119.026120","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T05:00:32Z","timestamp":1568264432000},"page":"2964-2966","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Outcomes of Surgery for Brainstem Cavernous Malformations"],"prefix":"10.1161","volume":"50","author":[{"given":"Kathryn N.","family":"Kearns","sequence":"first","affiliation":[{"name":"From the Department of Neurological Surgery, University of Virginia Health System, Charlottesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Department of Neurological Surgery, University of Virginia Health System, Charlottesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Tvrdik","sequence":"additional","affiliation":[{"name":"From the Department of Neurological Surgery, University of Virginia Health System, Charlottesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min S.","family":"Park","sequence":"additional","affiliation":[{"name":"From the Department of Neurological Surgery, University of Virginia Health System, Charlottesville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Yashar S.","family":"Kalani","sequence":"additional","affiliation":[{"name":"From the Department of Neurological Surgery, University of Virginia Health System, Charlottesville."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx091"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3171\/2010.6.FOCUS10128"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.193825"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2016.11.014"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2012.04.030"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000343668.44288.18"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.10.121"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-011-0477-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3171\/2014.5.JNS132276"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2013.10.012"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.08.117"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000002128"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-005-0671-7"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-013-1842-6"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s101430100179","article-title":"Cerebral cavernomas in the adult. Review of the literature and analysis of 72 surgically treated patients.","volume":"25","author":"Bertalanffy H","year":"2002","unstructured":"Bertalanffy, H, Benes, L, Miyazawa, T, Alberti, O, Siegel, AM, Sure, U. Cerebral cavernomas in the adult. Review of the literature and analysis of 72 surgically treated patients. Neurosurg Rev. 2002;25:1\u201353; discussion 54.","journal-title":"Neurosurg Rev"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.119.026120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:29:44Z","timestamp":1715599784000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.119.026120"}},"subtitle":["A Systematic Review"],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1161\/STROKEAHA.119.026120"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.119.026120","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"2019-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}