{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:22Z","timestamp":1787018122391,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>With the lack of confirmatory examinations, the distinction of a transient ischemic attack (TIA) from various TIA-mimicking diseases is difficult, particularly in diffusion-weighted imaging (DWI)-negative TIAs. In this study, we aimed to evaluate the relationship between arterial spin labeling (ASL) perfusion defects and early ischemic recurrence (FU-DWI [+]) in patients with DWI-negative TIAs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>We assessed consecutive patients with a DWI-negative TIA within 24 hours of symptom onset, who underwent both ASL images and follow-up magnetic resonance imaging during the acute period. As markers of the ASL images, we evaluated the ASL perfusion defects in each hemisphere. Arterial transit artifact (ATA) and intraarterial high-intensity signal (IAS) were also rated as markers of collateral status and blood stagnation due to large vessel occlusion, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>\n                      Among the 136 patients with a DWI-negative TIA, 33 patients had FU-DWI (+) lesions in 36 hemispheres. In the multivariable analysis, ASL defects remained an independent predictor of FU-DWI (+) (adjusted odds ratio, 13.94 [95% CI, 5.77\u201333.70],\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). In the evaluation of the interactive relationship between ASL defects and ATA\/IAS, the (ASL [+] ATA [\u2212]) group showed the highest frequencies of FU-DWI (+) events (55.6%) with the highest adjusted odds ratio values (adjusted odds ratio, 14.86 [95% CI, 5.63\u201339.24],\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), indicating a negative synergistic effect between the ASL defects and ATA. Meanwhile, the (ASL [+] IAS [+]) group showed higher frequencies of FU-DWI (+) and higher adjusted odds ratio values than those of the (ASL [+] IAS [\u2212]) and (ASL [\u2212] IAS [\u2212]) groups, indicating a positive synergistic effect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>We demonstrated that ASL perfusion defects were associated with ipsilateral FU-DWI (+) in patients with a DWI-negative TIA. Furthermore, this association was enhanced with IASs and attenuated with ATAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.119.026556","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T05:00:23Z","timestamp":1573621223000},"page":"186-192","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Regional Arterial Spin Labeling Perfusion Defect Is Associated With Early Ischemic Recurrence in Patients With a Transient Ischemic Attack"],"prefix":"10.1161","volume":"51","author":[{"given":"Ki-Woong","family":"Nam","sequence":"first","affiliation":[{"name":"From the Department of Neurology (K.-W.N., S.-B.K., B.-W.Y.), Seoul National University Hospital, Korea"},{"name":"Seoul National University College of Medicine, Korea (K.-W.N., S.-B.K., B.-W.Y., C.-H.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Korea University Guro Hospital, Seoul (C.K.K.)"},{"name":"Korea University College of Medicine, Seoul (C.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Bae","family":"Ko","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (K.-W.N., S.-B.K., B.-W.Y.), Seoul National University Hospital, Korea"},{"name":"Seoul National University College of Medicine, Korea (K.-W.N., S.-B.K., B.-W.Y., C.-H.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Woo","family":"Yoon","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (K.-W.N., S.-B.K., B.-W.Y.), Seoul National University Hospital, Korea"},{"name":"Seoul National University College of Medicine, Korea (K.-W.N., S.-B.K., B.-W.Y., C.-H.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roh-Eul","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Radiology (R.-E.Y., C.-H.S.), Seoul National University Hospital, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul-Ho","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Radiology (R.-E.Y., C.-H.S.), Seoul National University Hospital, Korea"},{"name":"Seoul National University College of Medicine, Korea (K.-W.N., S.-B.K., B.-W.Y., C.-H.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2011.01.003"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3551"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000339682"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.644971"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005034"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304005"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000147295.50029.67"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10592"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.539429"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3318"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2012.00728.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.4491"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003218"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069085"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2017.13.2.129"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.611376"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007797"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-017-1828-9"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000365653"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2016.04.015"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000238506.76873.2f"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.30.9.1751"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17725212"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2333031276"},{"key":"e_1_3_3_26_2","first-page":"1434","article-title":"False-negative diffusion-weighted MR findings in acute ischemic stroke.","volume":"21","author":"Oppenheim C","year":"2000","unstructured":"Oppenheim, C, Stanescu, R, Dormont, D, Crozier, S, Marro, B, Samson, Y, et al. False-negative diffusion-weighted MR findings in acute ischemic stroke. AJNR Am J Neuroradiol. 2000;21:1434\u20131440.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.29.11.2268"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13898"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011482"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.31.3.680"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.008496"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.03.035"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12880-018-0264-6"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.119.026556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:25:34Z","timestamp":1715599534000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.119.026556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1161\/STROKEAHA.119.026556"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.119.026556","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2019-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}