{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:28:03Z","timestamp":1790972883999,"version":"4.1.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>A large infarct and expanding cerebral edema (CED) due to a middle cerebral artery occlusion confers a 70% mortality unless treated surgically. Reperfusion may cause blood-brain barrier disruption and a risk for cerebral edema and secondary parenchymal hemorrhage (PH). We aimed to investigate the effect of recanalization on development of early CED and PH after recanalization therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>From the SITS-International Stroke Treatment Registry, we selected patients with signs of artery occlusion at baseline (either Hyperdense Artery Sign or computed tomography\/magnetic resonance imaging angiographic occlusion). We defined recanalization as the disappearance of radiological signs of occlusion at 22 to 36 hours. Primary outcome was moderate to severe CED and secondary outcome was PH on 22- to 36-hour imaging scans. We used logistic regression with adjustment for baseline variables and PH.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Twenty two thousand one hundred eighty-four patients fulfilled the inclusion criteria (n=18\u2009318 received intravenous thrombolysis, n=3071 received intravenous thrombolysis+thrombectomy, n=795 received thrombectomy). Recanalization occurred in 64.1%. Median age was 71 versus 71 years and National Institutes of Health Stroke Scale score 15 versus 16 in the recanalized versus nonrecanalized patients respectively. Recanalized patients had a lower risk for CED (13.0% versus 23.6%), adjusted odds ratio (aOR), 0.52 (95% CI, 0.46\u20130.59), and a higher risk for PH (8.9% versus 6.5%), adjusted odds ratio, 1.37 (95% CI, 1.22\u20131.55), than nonrecanalized patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In patients with acute ischemic stroke, recanalization was associated with a lower risk for early CED even after adjustment for higher rate for PH in recanalized patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.119.026692","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T10:00:16Z","timestamp":1575972016000},"page":"216-223","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":67,"title":["Effect of Recanalization on Cerebral Edema in Ischemic Stroke Treated With Thrombolysis and\/or Endovascular Therapy"],"prefix":"10.1161","volume":"51","author":[{"given":"Magnus","family":"Thor\u00e9n","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Karolinska University Hospital and Department of Clinical Neuroscience, Karolinska Institutet, Sweden (M.T., N.A.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Dixit","sequence":"additional","affiliation":[{"name":"Newcastle upon Tyne NHS Foundation Trust, University of Newcastle upon Tyne, United Kingdom (A.D.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Escudero-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Virgen del Roc\u00edo, Sevilla and Biomedicine Institute of Sevilla, Spain (I.E.-M.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Gdovinov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, P.J. Safarik University Ko\u0161ice, Slovak republic (Z.G.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Klecka","sequence":"additional","affiliation":[{"name":"Departement of Neurology, Municipal hospital of Ostrava, Czech Republic (L.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viiu-Marika","family":"Rand","sequence":"additional","affiliation":[{"name":"Department of Neurology, North Estonia Medical Centre, Tallinn (V.-M.R.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Toni","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Trattamento Neurovascolare, University La Sapienza Rome, Italy (D.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandras","family":"Vilionskis","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Clinical Medicine, Vilnius University, Republican Vilnius University hospital, Lithuania (A.V.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Wahlgren","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Karolinska Institutet, Sweden (N.W.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niaz","family":"Ahmed","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Karolinska University Hospital and Department of Clinical Neuroscience, Karolinska Institutet, Sweden (M.T., N.A.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.006884"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15617172"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70224-8"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200301000-00043"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70036-4"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12434"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17720559"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.5162"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014650"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60149-4"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93206-o"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.5.558"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.526772"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018223"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2012.00781.x"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.205.2.9356611"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2607"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.21554"},{"key":"e_1_3_4_20_2","volume-title":"OMODEL: Stata Modules to Perform Tests on Ordered Probit and Ordered Logit Models","author":"Wolfe R","year":"1997","unstructured":"Wolfe, R. 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