{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:23:47Z","timestamp":1790717027786,"version":"4.1.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>\n              The role of dual-antiplatelet therapy with clopidogrel plus aspirin has been demonstrated to substantially decrease the risk of recurrent stroke among patients with minor stroke and transient ischemic attack. We aimed to determine whether the efficacy of clopidogrel-aspirin therapy among patients with minor stroke \/ transient ischemic attack was influenced by the stratification of\n              <jats:italic>CYP2C19<\/jats:italic>\n              genotype and body mass index (BMI).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>\n              <jats:italic>CYP2C19<\/jats:italic>\n              loss-of-function allele (LoFA) carriers were defined as patients with either LoFA of *2 or *3. Low\/normal weight and overweight\/obesity was defined as BMI &lt;25 and \u226525 kg\/m\n              <jats:sup>2<\/jats:sup>\n              , respectively. Primary outcome was defined as stroke recurrence at 3 months.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              In a total of 2933 patients, there were 1726 (58.8%) LoFA carriers and 1275 (43.5%) patients with overweight\/obesity (BMI \u226525 kg\/m\n              <jats:sup>2<\/jats:sup>\n              ). Stratified analyses by LoFA carrying status and BMI, hazard ratios (hazard ratios 95% CIs) of the clopidogrel-aspirin therapy for stroke recurrence were 0.90 (0.60\u20131.36), 0.87 (0.56\u20131.35), 0.65 (0.39\u20131.09), and 0.40 (0.22\u20130.71) among subgroups of LoFA carriers with overweight\/obesity, LoFA carriers with low\/normal weight, LoFA noncarriers with overweight\/obesity, and LoFA noncarriers with low\/normal weight, respectively, with\n              <jats:italic>P<\/jats:italic>\n              =0.049 for interaction.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              Efficacy of clopidogrel-aspirin therapy in reducing the risk of stroke recurrence is not present in\n              <jats:italic>CYP2C19<\/jats:italic>\n              LoFA noncarriers with overweight\/obesity. Our study suggests that BMI significantly influences the correlation between\n              <jats:italic>CYP2C19<\/jats:italic>\n              genotype and efficacy of clopidogrel-aspirin therapy.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00979589.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.119.026845","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T10:00:23Z","timestamp":1573812023000},"page":"224-231","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy of Clopidogrel-Aspirin Therapy for Stroke Does Not Exist in\n            <i>C<\/i>\n            YP2C19 Loss-of-Function Allele Noncarriers With Overweight\/Obesity"],"prefix":"10.1161","volume":"51","author":[{"given":"Jinglin","family":"Mo","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (J.M., Z.C., J.X., A.W., L.D., A.C., X.M., H.L., Y.W.)"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, China (J.M., Z.C., J.X., A.W., L.D., A.C., X.M., H.L., Y.W.)"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, China (J.M., Z.C., J.X., A.W., L.D., A.C., X.M., H.L., Y.W.)"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (J.M., Z.C., J.X., A.W., L.D., A.C., X.M., H.L., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimo","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (J.M., Z.C., J.X., A.W., L.D., A.C., X.M., H.L., Y.W.)"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, China (J.M., Z.C., J.X., A.W., L.D., A.C., X.M., H.L., Y.W.)"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, China (J.M., Z.C., J.X., A.W., L.D., A.C., X.M., H.L., Y.W.)"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (J.M., Z.C., J.X., A.W., L.D., A.C., X.M., H.L., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (J.M., Z.C., J.X., A.W., L.D., A.C., X.M., H.L., Y.W.)"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, China (J.M., Z.C., J.X., A.W., L.D., A.C., X.M., H.L., Y.W.)"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, China (J.M., Z.C., J.X., A.W., L.D., A.C., X.M., H.L., Y.W.)"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (J.M., Z.C., J.X., A.W., L.D., A.C., X.M., H.L., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anxin","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (J.M., Z.C., J.X., A.W., L.D., A.C., X.M., 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