{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T23:46:41Z","timestamp":1783813601519,"version":"3.55.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Intravenous thrombolysis with r-tPA (recombinant tissue-type plasminogen activator) is associated with improved early functional outcome after stroke, but its long-term effects are less understood. We aimed to determine the association between r-tPA and 1-year outcomes after stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>\n              We used the Ontario Stroke Registry to identify patients diagnosed with ischemic stroke between 2002 and 2013 in Ontario, Canada, their baseline characteristics, and whether they received r-tPA. We used propensity score methods to match patients treated with r-tPA to nontreated patients. The primary outcome was 1-year home-time, defined as the number of days spent outside of any healthcare institutions in the first 365 days after the index date of admission. Secondary outcomes were admission to a nursing home and all-cause mortality in the first year. Outcomes were determined using linked administrative data. We used paired\n              <jats:italic>t<\/jats:italic>\n              tests to compare mean home-time days and Cox proportional hazards models for mortality and nursing home admission to estimate hazard ratios and 95% CI.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              All 4449 patients treated with r-tPA in the registry were matched to nontreated patients. Compared with nontreated patients, those treated with r-tPA experienced more time at home in the first year (mean\u00b1SD was 248.9 days\u00b1137.2 treated versus 239.4 days\u00b1139.0 nontreated,\n              <jats:italic>P<\/jats:italic>\n              =0.005) and were less likely to be admitted to nursing homes (9.4% treated versus 12.2% nontreated; hazard ratio, 0.84; 95% CI, 0.78\u20130.91). One-year all-cause mortality was similar between the 2 groups (13.2% treated versus 12.4% nontreated; hazard ratio, 1.07; 95% CI, 0.96\u20131.20).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Despite similar mortality, patients who received r-tPA spent more time at home and were less likely to require nursing home admission in the first year after stroke compared with nontreated patients, suggesting long-term benefits and safety of this treatment.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.119.026922","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T09:01:15Z","timestamp":1569920475000},"page":"3488-3493","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["One-Year Home-Time and Mortality After Thrombolysis Compared With Nontreated Patients in a Propensity-Matched Analysis"],"prefix":"10.1161","volume":"50","author":[{"given":"Amy Y.X.","family":"Yu","sequence":"first","affiliation":[{"name":"From the Department of Medicine (Neurology), University of Toronto, Sunnybrook Health Sciences Centre, ON, Canada (A.Y.X.Y.)"},{"name":"ICES, Toronto, ON, Canada (A.Y.X.Y., J.F., M.K.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiming","family":"Fang","sequence":"additional","affiliation":[{"name":"ICES, Toronto, ON, Canada (A.Y.X.Y., J.F., M.K.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira K.","family":"Kapral","sequence":"additional","affiliation":[{"name":"ICES, Toronto, ON, Canada (A.Y.X.Y., J.F., M.K.K.)"},{"name":"Department of Medicine (General Internal Medicine), University of Toronto-University Health Network, ON, Canada (M.K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60584-5"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804355"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1813046"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493018790024"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h1075"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2009.03.019"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004631"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.023916"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.04.008"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.601302"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.493320"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013563"},{"key":"e_1_3_4_14_2","unstructured":"Kapral MK Hall R Stamplecoski M Meyer S Asllani E Fang J et al. Registry of the canadian stroke network - report on the 2008\/09 ontario stroke audit. http:\/\/www.ices.on.ca\/~\/media\/Files\/Atlases-Reports\/2011\/RCSN-2008-2009-Ontario-stroke-audit\/Full%2020report.ashx. Accessed August 29 2019."},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826aac9b"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.121418"},{"key":"e_1_3_4_17_2","volume-title":"In. Proceedings from the Canadian Association for Health Services and Policy Research Conference","author":"Mojaverian N","unstructured":"Mojaverian, N, Ng, R, Hsu, A, Lane, N, Tanuseputro, P, Wodchis, WP. Validation of incident long-term care admissions in ontario using administrative data (oral presentation). In. Proceedings from the Canadian Association for Health Services and Policy Research Conference; May 24, 2017. https:\/\/www.cahspr.ca\/web\/uploads\/conference\/2017-05-24_Oral_Presentations.pdf. Accessed December 5, 2018."},{"key":"e_1_3_4_18_2","unstructured":"Juurlink D Preyra C Croxford R Chong A Austin P Tu JV et al. Canadian institute for health information discharge abstract database: A validation study. https:\/\/www.ices.on.ca\/publications\/atlases-and-reports\/2006\/canadian-institute-for-health-information. Accessed August 29 2019."},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2011.568786"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/pst.433"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3697"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017719"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000558"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.111.000303"},{"key":"e_1_3_4_25_2","unstructured":"Canadian Stroke Network. Quality of stroke care in canada 2011. http:\/\/canadianstrokenetwork.ca\/en\/service\/quality-of-stroke-care-in-canada-2011\/. Accessed July 9 2019."},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-016-0414-6"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.019889"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.09.009"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414792"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.119.026922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:27:25Z","timestamp":1715614045000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.119.026922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1161\/STROKEAHA.119.026922"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.119.026922","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"2019-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}