{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:47:01Z","timestamp":1792234021203,"version":"4.4.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>APOE-\u03b54 genotype is a risk factor for sporadic Alzheimer disease and reduced recovery from brain injury. Since data on APOE genotype and dementia associated with transient ischemic attack\/stroke are sparse, we determined the associations in a longitudinal population-based cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>All patients with transient ischemic attack or stroke (2002\u20132012) in a defined population of 92 728 OxVASC (Oxford Vascular Study) had follow-up to 5-years. Pre-event and incident postevent dementia were ascertained through direct patient assessment and follow-up, supplemented by review of hospital\/primary care records. Associations between pre- and post-event dementia and APOE genotype (\u03b54\/\u03b54-homozygous and \u03b54\/\u03b53-heterozygous versus \u03b53\/\u03b53) were examined using logistic regression and Cox regression models, respectively, adjusted for age, sex, education, cerebrovascular burden (stroke severity, prior stroke, white matter disease), diabetes mellitus, and dysphasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>\n                      Among 1767 genotyped patients (mean\/SD age, 73.0\/13.0 years, 901 [51%] male, 602 [34%] transient ischemic attack), 1058 (59.9%) were APOE-\u03b53\/\u03b53, 403 (22.8%) were \u03b54\/\u03b53 and 30 (1.7%) were \u03b54-homozygous. Homozygosity was associated with both pre-event (adjusted odds ratio, 5.81 [95% CI, 1.93\u201317.48];\n                      <jats:italic>P<\/jats:italic>\n                      =0.002) and postevent dementia (adjusted hazard ratio, 3.64 [95% CI, 1.90\u20137.00];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001). Association with postevent dementia was maintained after further adjustment for baseline cognitive impairment (hazard ratio, 2.41 [95% CI, 1.19\u20134.89];\n                      <jats:italic>P<\/jats:italic>\n                      =0.01). There were no associations overall between \u03b54\/\u03b53 and pre-event dementia (adjusted odds ratio, 1.47 [95% CI, 0.88\u20132.45];\n                      <jats:italic>P<\/jats:italic>\n                      =0.14) or postevent dementia (hazard ratio, 1.11 [95% CI, 0.84\u20131.48];\n                      <jats:italic>P<\/jats:italic>\n                      =0.47).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>In patients with transient ischemic attack and stroke, APOE-\u03b54 homozygosity was associated with both pre- and post-event dementia. Associations were independent of cerebrovascular burden and may be mediated through increased neurodegenerative pathology or vulnerability to injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.119.026927","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T14:02:07Z","timestamp":1582552927000},"page":"751-758","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":75,"title":["APOE-\u03b54 Genotype and Dementia Before and After Transient Ischemic Attack and Stroke"],"prefix":"10.1161","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3603-8388","authenticated-orcid":false,"given":"Sarah T.","family":"Pendlebury","sequence":"first","affiliation":[{"name":"From the Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital and the University of Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Poole","sequence":"additional","affiliation":[{"name":"From the Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital and the University of Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Burgess","sequence":"additional","affiliation":[{"name":"From the Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital and the University of Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Duerden","sequence":"additional","affiliation":[{"name":"From the Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital and the University of Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Rothwell","sequence":"additional","affiliation":[{"name":"From the Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital and the University of Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Oxford Vascular Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-3010-7_3"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70325-2"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550160069041"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.2152"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-306485"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0140-6736(95)91411-0","article-title":"APOE genotype and survival from intracerebral haemorrhage.","volume":"346","author":"Alberts MJ","year":"1995","unstructured":"Alberts, MJ, Graffagnino, C, McClenny, C, DeLong, D, Strittmatter, W, Saunders, AM et al. 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