{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:35:40Z","timestamp":1773405340165,"version":"3.50.1"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Hypertension is the most frequent comorbidity in stroke.The purpose of this study was to evaluate whether hypertension alters the response to treatment with adipose tissue-derived mesenchymal stem cells (ADMSCs) after an ischemic stroke in rats.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>\n              Ischemic stroke was induced in male normotensive or hypertensive rats. Either vehicle or 1\u00d710\n              <jats:sup>6<\/jats:sup>\n              ADMSC was intravenously administered at 48 hours poststroke. Functional outcome, lesion size and volume, and markers of brain repair (GFAP [glial fibrillary acidic protein], doublecortin, CD-31, \u03b1-smooth muscle actin) were evaluated.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Hypertensive rats had larger lesions, higher apparent diffusion coefficients (ADC) and worse functional outcomes than normotensive rats. Hypertension increased GFAP and vascular markers (CD-31 and \u03b1-smooth muscle actin). The hypertensive rats treated with ADMSC did not show any significant improvement in functional recovery, lesion size, ADC values, or histological markers compared with those which received the vehicle.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>ADMSC did not reverse the hypertension-induced increase in lesion severity or functional impairment. Gliosis, neurogenesis, or vascular markers were not affected by ADMSC in hypertensive rats. Hypertension has a negative impact on the therapeutic effect of ADMSC after an ischemic stroke.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.119.027133","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T10:00:16Z","timestamp":1573120816000},"page":"342-346","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Mesenchymal Stem Cells From Adipose Tissue Do not Improve Functional Recovery After Ischemic Stroke in Hypertensive Rats"],"prefix":"10.1161","volume":"51","author":[{"given":"Luke","family":"Diekhorst","sequence":"first","affiliation":[{"name":"From the Neuroscience and Cerebrovascular Research Laboratory, Department of Neurology and Stroke Center, La Paz University Hospital, Neuroscience Area of IdiPAZ Health Research Institute, Autonomous University of Madrid (UAM), Madrid, Spain (L.D., M.C.G.-d.F., F.L.-G., L.O.-O., B.F., A.M.-A., E.D.-T., M.G.-F.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari Carmen","family":"G\u00f3mez-de Frutos","sequence":"additional","affiliation":[{"name":"From the Neuroscience and Cerebrovascular Research Laboratory, Department of Neurology and Stroke Center, La Paz University Hospital, Neuroscience Area of IdiPAZ Health Research Institute, Autonomous University of Madrid (UAM), Madrid, Spain (L.D., M.C.G.-d.F., F.L.-G., L.O.-O., B.F., A.M.-A., E.D.-T., M.G.-F.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Laso-Garc\u00eda","sequence":"additional","affiliation":[{"name":"From the Neuroscience and Cerebrovascular Research Laboratory, Department of Neurology and Stroke Center, La Paz University Hospital, Neuroscience Area of IdiPAZ Health Research Institute, Autonomous University of Madrid (UAM), Madrid, Spain (L.D., M.C.G.-d.F., F.L.-G., L.O.-O., B.F., A.M.-A., E.D.-T., M.G.-F.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Otero-Ortega","sequence":"additional","affiliation":[{"name":"From the Neuroscience and Cerebrovascular Research Laboratory, Department of Neurology and Stroke Center, La Paz University Hospital, Neuroscience Area of IdiPAZ Health Research Institute, Autonomous University of Madrid (UAM), Madrid, Spain (L.D., M.C.G.-d.F., F.L.-G., L.O.-O., B.F., A.M.-A., E.D.-T., M.G.-F.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Fuentes","sequence":"additional","affiliation":[{"name":"From the Neuroscience and Cerebrovascular Research Laboratory, Department of Neurology and Stroke Center, La Paz University Hospital, Neuroscience Area of IdiPAZ Health Research Institute, Autonomous University of Madrid (UAM), Madrid, Spain (L.D., M.C.G.-d.F., F.L.-G., L.O.-O., B.F., A.M.-A., E.D.-T., M.G.-F.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Jolkkonen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Eastern Finland, Kuopio University Hospital (J.J.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Detante","sequence":"additional","affiliation":[{"name":"Stroke Unit, Neurology Department, Grenoble Hospital, France (O.D.)"},{"name":"Grenoble Institute of Neurosciences, Inserm U1216, Grenoble Alpes University, France (O.D., A.M.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anaick","family":"Moisan","sequence":"additional","affiliation":[{"name":"Grenoble Institute of Neurosciences, Inserm U1216, Grenoble Alpes University, France (O.D., A.M.)"},{"name":"Cell Therapy and Engineering Unit, EFS Auvergne Rh\u00f4ne Alpes, Saint-Ismier, France (A.M.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Leyva","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Hospital Regional Universitario de M\u00e1laga, Spain (L.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Mart\u00ednez-Arroyo","sequence":"additional","affiliation":[{"name":"From the Neuroscience and Cerebrovascular Research Laboratory, Department of Neurology and Stroke Center, La Paz University Hospital, Neuroscience Area of IdiPAZ Health Research Institute, Autonomous University of Madrid (UAM), Madrid, Spain (L.D., M.C.G.-d.F., F.L.-G., L.O.-O., B.F., A.M.-A., E.D.-T., M.G.-F.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Exuperio","family":"D\u00edez-Tejedor","sequence":"additional","affiliation":[{"name":"From the Neuroscience and Cerebrovascular Research Laboratory, Department of Neurology and Stroke Center, La Paz University Hospital, Neuroscience Area of IdiPAZ Health Research Institute, Autonomous University of Madrid (UAM), Madrid, Spain (L.D., M.C.G.-d.F., F.L.-G., L.O.-O., B.F., A.M.-A., E.D.-T., M.G.-F.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Guti\u00e9rrez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"From the Neuroscience and Cerebrovascular Research Laboratory, Department of Neurology and Stroke Center, La Paz University Hospital, Neuroscience Area of IdiPAZ Health Research Institute, Autonomous University of Madrid (UAM), Madrid, Spain (L.D., M.C.G.-d.F., F.L.-G., L.O.-O., B.F., A.M.-A., E.D.-T., M.G.-F.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of RESSTORE 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