{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:24:51Z","timestamp":1791563091540,"version":"4.3.4"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>In ischemic stroke, body temperature is associated with functional outcome. However, the relationship between temperature and outcome may differ in the intraischemic and postischemic phases of stroke. We aimed to determine whether body temperature before or after endovascular thrombectomy (EVT) for large vessel occlusion stroke is associated with clinical outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Consecutive EVT patients were identified from a prospective registry. Temperature measurements within 24 hours of admission were stratified into pre-EVT (preprocedural and intraprocedural) and post-EVT measurements, which served as surrogates for the intraischemic and postischemic phases of large vessel occlusion stroke, respectively. The primary outcome was functional independence, defined as a modified Rankin Scale score of 0, 1, or 2 at 3 months. Secondary outcomes included the ordinal shift of modified Rankin Scale scores at 3 months, symptomatic intracerebral hemorrhage, and mortality at 3 months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Four hundred thirty-two participants were included (59% men, mean\u00b1SD age 65.6\u00b115.7 years). Multivariable logistic regression demonstrated that higher median pre-EVT temperature (per 1\u00b0C increase) was an independent predictor of reduced functional independence (odds ratio [OR], 0.66 [95% CI, 0.46\u20130.94];\n              <jats:italic>P<\/jats:italic>\n              =0.02), poorer modified Rankin Scale scores (common OR, 1.42 [95% CI, 1.08\u20131.85];\n              <jats:italic>P<\/jats:italic>\n              =0.01), and increased mortality (OR, 1.65 [95% CI, 1.02\u20132.69];\n              <jats:italic>P<\/jats:italic>\n              =0.04). Peak post-EVT temperature (per 1\u00b0C increase) was a significant predictor of elevated modified Rankin Scale scores (common OR, 1.39 [95% CI, 1.03\u20131.90];\n              <jats:italic>P<\/jats:italic>\n              =0.03) and higher mortality (OR, 1.66 [95% CI, 1.04\u20132.67];\n              <jats:italic>P<\/jats:italic>\n              =0.03).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In patients with large vessel occlusion stroke treated with EVT, higher body temperatures during both the intraischemic and postischemic phases were associated with poorer clinical outcomes. Future research investigating the maintenance of normothermia or therapeutic hypothermia in patients needing to be transferred from primary to EVT-capable stroke centers could be considered.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.119.028160","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T18:56:52Z","timestamp":1584557812000},"page":"1218-1225","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Impact of Body Temperature Before and After Endovascular Thrombectomy for Large Vessel Occlusion Stroke"],"prefix":"10.1161","volume":"51","author":[{"given":"William K.","family":"Diprose","sequence":"first","affiliation":[{"name":"From the Department of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand (W.K.D., M.T.M.W., P.A.B.)"},{"name":"Department of Neurology (W.K.D., B.L., P.A.B.), Auckland City Hospital, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Liem","sequence":"additional","affiliation":[{"name":"Department of Neurology (W.K.D., B.L., P.A.B.), Auckland City Hospital, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.M.","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand (W.K.D., M.T.M.W., P.A.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Sutcliffe","sequence":"additional","affiliation":[{"name":"Department of Radiology (J.A.S., S.B., J.R.C., B.M.), Auckland City Hospital, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Brew","sequence":"additional","affiliation":[{"name":"Department of Radiology (J.A.S., S.B., J.R.C., B.M.), Auckland City Hospital, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Caldwell","sequence":"additional","affiliation":[{"name":"Department of Radiology (J.A.S., S.B., J.R.C., B.M.), Auckland City Hospital, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"McGuinness","sequence":"additional","affiliation":[{"name":"Department of Radiology (J.A.S., S.B., J.R.C., B.M.), Auckland City Hospital, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doug","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Perioperative Medicine (D.C.), Auckland City Hospital, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2469-9023","authenticated-orcid":false,"given":"P. 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