{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:53:02Z","timestamp":1790041982275,"version":"4.0.1"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>Antiplatelet agents could be used in the setting of endovascular therapy for tandem occlusions to reduce the risk of de novo intracranial embolic migration, reocclusion of the extracranial internal carotid artery lesion, or in-stent thrombosis in case of carotid stent placement but have to be balanced with the intracerebral hemorrhagic transformation risk. In this study, we aim to investigate the impact of acute antiplatelet therapy administration on outcomes during endovascular therapy for anterior circulation tandem occlusions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>This is a retrospective analysis of a collaborative pooled analysis of 11 prospective databases from the multicenter observational TITAN registry (Thrombectomy in Tandem Lesions). Patients were divided into groups based on the number of antiplatelet administered during endovascular therapy. The primary outcome was favorable outcome, defined as a modified Rankin Scale score of 0 to 2 at 90 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>\n                      This study included a total of 369 patients; 145 (39.3%) did not receive any antiplatelet agent and 224 (60.7%) received at least 1 antiplatelet agent during the procedure. Rate of favorable outcome was nonsignificantly higher in patients treated with antiplatelet therapy (58.3%) compared with those treated without antiplatelet (46.0%; adjusted odds ratio, 1.38 [95% CI, 0.78\u20132.43];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.26). Rate of 90-day mortality was significantly lower in patients treated with antiplatelet therapy (11.2% versus 18.7%; adjusted odds ratio, 0.47 [95% CI, 0.22\u20130.98];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.042), without increasing the risk of any intracerebral hemorrhage. Successful reperfusion (modified Thrombolysis in Cerebral Ischemia score 2b-3) rate was significantly better in the antiplatelet therapy group (83.9% versus 71.0%; adjusted odds ratio, 1.89 [95% CI, 1.01\u20133.64];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.045).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Administration of antiplatelet therapy during endovascular therapy for anterior circulation tandem occlusions was safe and was associated with a lower 90-day mortality. Optimal antiplatelet therapy remains to be assessed, especially when emergent carotid artery stenting is performed. Further randomized controlled trials are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.119.028231","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T05:00:48Z","timestamp":1584594048000},"page":"1522-1529","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":65,"title":["Impact of Antiplatelet Therapy During Endovascular Therapy for Tandem Occlusions"],"prefix":"10.1161","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3838-9608","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Zhu","sequence":"first","affiliation":[{"name":"From the Department of Diagnostic and Therapeutic Neuroradiology, University Hospital of Nancy, France (F.Z., R.A., S.B., B.G.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Anadani","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, St. Louis, MO (M.A.)"},{"name":"Department of Neurosurgery, Medical University of South Carolina, Charleston (A.S., M.A.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Labreuche","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, EA 2694\u2013Sant\u00e9 Publique: Epid\u00e9miologie et Qualit\u00e9 des Soins, University of Lille, CHU Lille, France (J.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Spiotta","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University of South Carolina, Charleston (A.S., M.A.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Turjman","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (F.T.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Piotin","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Steglich-Arnholm","sequence":"additional","affiliation":[{"name":"Department of Neurology (H.S.-A.), Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Holtmannsp\u00f6tter","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Taschner","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Medical Center-University of Freiburg, Germany (C.T., 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