{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:14:09Z","timestamp":1791231249610,"version":"4.1.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>We aimed to compare functional and procedural outcomes of patients with acute ischemic stroke with none-to-minimal (modified Rankin Scale [mRS] score, 0\u20131) and moderate (mRS score, 2\u20133) prestroke disability treated with mechanical thrombectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>\n                      Consecutive adult patients undergoing mechanical thrombectomy for an anterior circulation stroke were prospectively identified at 2 comprehensive stroke centers from 2012 to 2018. Procedural and 90-day functional outcomes were compared among patients with prestroke mRS scores 0 to 1 and 2 to 3 using \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      , logistic, and linear regression tests. Primary outcome and significant differences in secondary outcomes were adjusted for prespecified covariates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>\n                      Of 919 patients treated with mechanical thrombectomy, 761 were included and 259 (34%) patients had moderate prestroke disability. Ninety-day mRS score 0 to 1 or no worsening of prestroke mRS was observed in 36.7% and 26.7% of patients with no-to-minimal and moderate prestroke disability, respectively (odds ratio, 0.63 [0.45\u20130.88],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.008; adjusted odds ratio, 0.90 [0.60\u20131.35],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.6). No increase in the disability at 90 days was observed in 22.4% and 26.7%, respectively. Rate of symptomatic intracerebral hemorrhage (7.3% versus 6.2%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.65), successful recanalization (86.7% versus 83.8%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.33), and median length of hospital stay (5 versus 5 days,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.06) were not significantly different. Death by 90 days was higher in patients with moderate prestroke disability (14.3% versus 40.3%; odds ratio, 4.06 [2.82\u20135.86],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001; adjusted odds ratio, 2.83 [1.84, 4.37],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>One-third of patients undergoing mechanical thrombectomy had a moderate prestroke disability. There was insufficient evidence that functional and procedural outcomes were different between patients with no-to-minimal and moderate prestroke disability. Patients with prestroke disability were more likely to die by 90 days.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.119.028246","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T05:00:25Z","timestamp":1586408425000},"page":"1539-1545","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":64,"title":["Mechanical Thrombectomy in Patients With Ischemic Stroke With Prestroke Disability"],"prefix":"10.1161","volume":"51","author":[{"given":"Sanjana","family":"Salwi","sequence":"first","affiliation":[{"name":"From the School of Medicine, Vanderbilt University, Nashville, TN (S.S.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawna","family":"Cutting","sequence":"additional","affiliation":[{"name":"Departments of Neurology (S.C., T.B., B.M., A.S., K.D.), Rhode Island Hospital, Providence"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan 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V.","family":"Chitale","sequence":"additional","affiliation":[{"name":"Neurosurgery (M.R.F., R.V.C., A.M.M.), Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Kirshner","sequence":"additional","affiliation":[{"name":"Departments of Neurology (A.D.S., K.E., H.K., M.S., E.A.M.), Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Schrag","sequence":"additional","affiliation":[{"name":"Departments of Neurology (A.D.S., K.E., H.K., M.S., E.A.M.), Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Jasne","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale University School of Medicine, New Haven, CT 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