{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:33:58Z","timestamp":1790076838939,"version":"4.0.1"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose:<\/jats:title>\n            <jats:p>We aimed to determine whether lobar cerebellar microbleeds or concomitant lobar cerebellar and deep microbleeds, in the presence of lobar cerebral microbleeds, attribute to underlying advanced cerebral amyloid angiopathy pathology or hypertensive arteriopathy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We categorized 71 patients with suspected cerebral amyloid angiopathy markers (regardless of the presence of deep and cerebellar microbleeds) into 4 groups according to microbleed distribution: L (strictly lobar cerebral, n=33), L\/LCbll (strictly lobar cerebral and strictly lobar cerebellar microbleeds, n=13), L\/Cbll\/D (lobar, cerebellar, and deep microbleeds, n=17), and L\/D (lobar and deep, n=8). We additionally categorized patients with cerebellar microbleeds into 2 groups according to dentate nucleus involvement: strictly lobar cerebellar (n=16) and dentate (n=14). We then compared clinical characteristics, A\u03b2 (amyloid-\u03b2) positivity on PET (positron emission tomography), magnetic resonance imaging cerebral amyloid angiopathy markers, and cerebral small vessel disease burden among groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              The frequency of A\u03b2 positivity was higher in the L and L\/LCbll groups (81.8% and 84.6%) than in the L\/Cbll\/D and L\/D groups (37.5% and 29.4%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), while lacune numbers were lower in the L and L\/LCbll groups (1.7\u00b13.3 and 1.7\u00b12.6) than in the L\/Cbll\/D and L\/D groups (8.0\u00b110.3 and 13.4\u00b117.7,\n              <jats:italic>P<\/jats:italic>\n              =0.001). The L\/LCbll group had more lobar cerebral microbleeds than the L group (93.2\u00b1121.8 versus 38.0\u00b140.8,\n              <jats:italic>P<\/jats:italic>\n              =0.047). The lobar cerebellar group had a higher A\u03b2 positivity (75% versus 28.6%,\n              <jats:italic>P<\/jats:italic>\n              =0.011) and lower lacune number (2.3\u00b13.7 versus 8.6\u00b11.2,\n              <jats:italic>P<\/jats:italic>\n              =0.041) than the dentate group.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Strictly lobar cerebral and cerebellar microbleeds are related to cerebral amyloid angiopathy, whereas any combination of concurrent lobar and deep microbleeds suggest hypertensive angiopathy regardless of cerebral or cerebellar compartments.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.119.028487","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T10:00:37Z","timestamp":1605607237000},"page":"3600-3607","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["Strictly Lobar Microbleeds Reflect Amyloid Angiopathy Regardless of Cerebral and Cerebellar Compartments"],"prefix":"10.1161","volume":"51","author":[{"given":"Young Hee","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Neurology, Myongji Hospital, Hanyang University, Goyang, Korea (Y.H.J)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3152-1274","authenticated-orcid":true,"given":"Hyemin","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."},{"name":"Neuroscience Center, Samsung Medical Center, Samsung Alzheimer Research Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Beom","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."},{"name":"Neuroscience Center, Samsung Medical Center, Samsung Alzheimer Research Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Sim","family":"Choe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."},{"name":"Neuroscience Center, Samsung Medical Center, Samsung Alzheimer Research Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."},{"name":"Neuroscience Center, Samsung Medical Center, Samsung Alzheimer Research Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."},{"name":"Neuroscience Center, Samsung Medical Center, Samsung Alzheimer Research Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."},{"name":"Neuroscience Center, Samsung Medical Center, Samsung Alzheimer Research Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Pyo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."},{"name":"Neuroscience Center, Samsung Medical Center, Samsung Alzheimer Research Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."},{"name":"Neuroscience Center, Samsung Medical Center, Samsung Alzheimer Research Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk L.","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."},{"name":"Neuroscience Center, Samsung Medical Center, Samsung Alzheimer Research Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."},{"name":"Stem Cell &amp; Regenerative Medicine Institute, Samsung Medical Center, Seoul, Korea (D.L.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8747-0122","authenticated-orcid":true,"given":"Sang Won","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."},{"name":"Neuroscience Center, Samsung Medical Center, Samsung Alzheimer Research Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea (H.J., S.B.P., S.H.K., J.M.L., J.S.K., J.K., J.P.K., H.J.K., D.L.N., S.W.S.)."},{"name":"Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea (S.W.S.)."},{"name":"Department of Health Science and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea (S.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","first-page":"637","article-title":"Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds.","volume":"20","author":"Fazekas F","year":"1999","unstructured":"Fazekas, F, Kleinert, R, Roob, G, Kleinert, G, Kapeller, P, Schmidt, R, Hartung, HP. 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